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Vitreous levels of vascular endothelial growth factor and intercellular adhesion molecule 1 are related to diabetic macular edema.

Abstract：

PURPOSE:To investigate whether vascular endothelial growth factor (VEGF) or soluble intercellular adhesion molecule 1 (sICAM-1) is related to diabetic macular edema (DME). DESIGN:Retrospective case-control study. PARTICIPANTS:Thirty-three patients who had DME and 13 patients with nondiabetic ocular disease (control group). METHODS:Vitreous fluid samples were obtained at the time of vitreoretinal surgery, and the VEGF and sICAM-1 levels in vitreous fluid and plasma were measured by enzyme-linked immunosorbent assay. MAIN OUTCOME MEASURES:Relationship between vitreous levels of VEGF or sICAM-1 and DME. RESULTS:Vitreous levels of VEGF and sICAM-1 were significantly higher in DME patients than in control patients (P < 0.0001 and P = 0.0004, respectively). The vitreous level of VEGF was significantly correlated with that of sICAM-1 (P < 0.0001). Vitreous levels of both VEGF and sICAM-1 were significantly higher in patients with hyperfluorescent DME than in those with minimally fluorescent DME (P = 0.0027 and P = 0.0005, respectively). The vitreous levels of both VEGF and sICAM-1 were significantly correlated with retinal thickness at the central fovea (P < 0.0001 and P = 0.0005, respectively) CONCLUSIONS:We found that both VEGF and sICAM-1 were elevated in the vitreous fluid of patients with hyperfluorescent DME. These results suggest that VEGF and ICAM-1 are related to the increase of vascular permeability in DME patients.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Funatsu H,Yamashita H,Sakata K,Noma H,Mimura T,Suzuki M,Eguchi S,Hori S

doi

10.1016/j.ophtha.2004.11.045

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

806-16

issue

5

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(04)01911-6

journal_volume

112

pub_type

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