Abstract:
:This research was carried out to evaluate the prevalence of carotid and/or lower limb artery abnormalities in patients with arterial erectile dysfunction (ED). To this end, patients with ED (Andrology Unit) or suspected peripheral atherosclerosis (Angiology Unit) underwent an independent and parallel echo-Duplex examination. The Andrology Unit examined 167 patients with ED of different etiologies: 52 of them had penile artery insufficiency and consequently their carotids and lower limb arteries had to be evaluated by means of echo-Doppler. In all, 36 out of the 46 patients with nonarterial organic ED and 22 out of the 69 patients with nonorganic ED underwent the same evaluation and served as controls. The Angiology Unit enrolled 457 ED patients who initially underwent echo-Doppler for suspected carotid and/or arterial leg atherosclerosis and subsequently dynamic echo-Doppler. Isolated penile artery insufficiency was found in 23.1 and 25% of the patients evaluated in the Angiology and Andrology Units, respectively. The remaining patients were shown to have ED associated with an atheroma or marked intima-media thickness of the carotid vessels and/or of leg arteries. The frequency of penile arterial insufficiency and of carotid and/or lower limb artery abnormalities was significantly higher (P < 0.01) compared to that found in patients with ED of nonarterial organic or psychogenic origin. Both Units found that the frequency of penile artery insufficiency and carotid or lower limb artery abnormalities was significantly higher than that of penile artery insufficiency alone or plus both carotid and lower limb artery abnormalities. This study showed that penile artery insufficiency is associated with carotid and/or lower limb artery ultrasound abnormalities in about 75% of the cases. Therefore, arterial ED may be regarded as a sign of a more generalized atherosclerosis.
journal_name
Int J Impot Resjournal_title
International journal of impotence researchauthors
Vicari E,Arcidiacono G,Di Pino L,Signorelli S,Arancio A,Sorrentino F,Battiato C,D'Agata R,Calogero AEdoi
10.1038/sj.ijir.3901312subject
Has Abstractpub_date
2005-05-01 00:00:00pages
277-82issue
3eissn
0955-9930issn
1476-5489pii
3901312journal_volume
17pub_type
杂志文章abstract::The authors created the glans penis augmentation by injectable hyaluronic acid gel and reported the 6-month result for premature ejaculation. In a total of 38 patients, long-term effects of 5 years were compared to those of 6 months in terms of residual volume of implants and efficacy on premature ejaculation. Maximal...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2008.26
更新日期:2008-07-01 00:00:00
abstract::The objective of this study was to investigate the predictive validity of the Dutch translation of the Golombok Rust Inventory of Sexual Satisfaction (GRISS) for the presence of clinically relevant sexual dysfunctions and patient's need of help. A total of 57 male urological outpatients (age 50.7+/-13.2 y; range 27-77...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900966
更新日期:2003-04-01 00:00:00
abstract::We studied the association between erythrocyte aggregation (EA) and erectile dysfunction (ED) in men with coronary artery disease (CAD). Men with CAD documented by coronary angiography filled the Sexual Health Inventory for Males questionnaire to detect ED and assess its severity. EA was evaluated by filming slides of...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2009.6
更新日期:2009-05-01 00:00:00
abstract::Erectile dysfunction (ED) is the consistent inability to achieve and maintain an erection sufficient for satisfactory sexual activity. Erectile dysfunction affects as many as 30 million men in America, with an increasing prevalence with age. Erectile dysfunction is secondary to organic, psychogenic and combined causes...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/sj.ijir.3901477
更新日期:2007-01-01 00:00:00
abstract::Dissection of the pudendal nerve (PN) and its branches in 71 cadavers revealed anatomic variations not previously described. Knowledge of this variation is necessary to prevent nerve injury resulting in sexual of sensory dysfunction. Because descriptions vary, this study re-evaluated the anatomy of the PN as implicate...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2015.10
更新日期:2015-07-01 00:00:00
abstract::Both RigiScan and the Snap Gauge band devices are used to objectively measure penile rigidity. The Snap Gauge band is the more simple and inexpensive of the two techniques. We investigated the correlation between the results obtained by both devices in order to evaluate whether the Snap Gauge band could be employed as...
journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章
doi:10.1038/sj.ijir.3900438
更新日期:1999-12-01 00:00:00
abstract::This workshop completes the trilogy of nuances of the various incisions used to place an inflatable penile prosthesis (IPP). Infrapubic placement was the original technique employed 50 years ago for the very first IPP surgeries. The historical perspective of the development of implantation incisions and the original S...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/s41443-020-00370-y
更新日期:2020-12-18 00:00:00
abstract::The first goal of this study was to examine the effect of secondhand smoking on neurogenic, endothelium- and cGMP-dependent relaxant responses of rabbit corpus cavernosum smooth muscle. Our second goal was to determine whether such an effect can be prevented by oral administration of L-arginine. Male New Zealand rabbi...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901341
更新日期:2005-09-01 00:00:00
abstract::The aim of our study was to describe the impact of mid-urethral sling procedure for the treatment of stress urinary incontinence (SUI) on female sexual function. We used PubMed (updated March 2015) to conduct a literature electronic search that included peer-reviewed English language articles. We analyzed the studies ...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/ijir.2016.16
更新日期:2016-07-01 00:00:00
abstract::Sexual dysfunction is a common problem of increasing incidence that is associated with multiple co-morbid conditions and chronic diseases. In heart failure, however, exact numbers are unknown, in part secondary to under-reporting and under-interrogating by health care providers. A gender-specific questionnaire was mod...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901613
更新日期:2008-01-01 00:00:00
abstract::Nitric oxide (NO) is a physiologic signal essential to penile erection, and disorders that reduce NO synthesis or release in the erectile tissue are commonly associated with erectile dysfunction. NO synthase (NOS) catalyzes production of NO from L-arginine. While both constitutively expressed neuronal NOS (nNOS) and e...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/sj.ijir.3901209
更新日期:2004-06-01 00:00:00
abstract::Sildenafil citrate, marketed as Viagra, for the treatment of erectile dysfunction, has a proven record of safety in humans as predicted by the results of extensive pharmacological and toxicological testing in animals and in vitro, and confirmed by pharmacokinetic exposure data. The aim of this paper is to review succi...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/sj.ijir.3901232
更新日期:2004-12-01 00:00:00
abstract::This randomized controlled cross-over study aimed to assess the efficacy and safety of glans penis injection with hyaluronic acid (HA) in treating premature ejaculation (PE). A total of 30 patients with PE were randomly allocated into two groups: group 1 (n = 15) which was subjected to glans penis HA injection and gro...
journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41443-018-0104-9
更新日期:2019-09-01 00:00:00
abstract::A total of 76 male patients on renal replacement therapy (RRT) were investigated. Erectile dysfunction (ED) was defined as insufficient erection during visual erotic stimulation (VES) or during sleep as measured with Rigiscan and Erectiometer. Data on medical history, physical examination, and laboratory variables wer...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900946
更新日期:2003-02-01 00:00:00
abstract::Although several studies on toxic effect of aspartame metabolite have been studied, controversial reports over the use of aspartame owing to the fact that it releases methanol as one of its metabolite during metabolism exist. This present study is proposed to investigate whether aspartame (40 mg kg-1 b.wt) administrat...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2017.17
更新日期:2017-07-01 00:00:00
abstract::Even with the help of modern pharmacology, treatment of erectile dysfunction often remains complex, and requires taking into account the social, psychological, and behavioral dimensions of the disorder. This brief report presents a case study highlighting this complexity. ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901322
更新日期:2005-07-01 00:00:00
abstract::We have investigated the reliability of intracavernosal prostaglandin E1 (PGE1) office vs self-injection therapy in patients with erectile dysfunction (ED). A total of 298 male patients with ED were enrolled in this study. In all patients, intracavernosal titration of the PGE1 dose was performed. A total of 106 patien...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901388
更新日期:2006-03-01 00:00:00
abstract::Venous insufficiency of the corpora cavernosa is the second most common cause of erectile dysfunction (ED). A functional insufficiency of the venous system has been hypothesised, but the cause is still unclear. To evaluate a possible endocrine mechanism, we have studied hormone profile in a group of nine patients with...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901287
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:Quality of life (QOL) data were used to evaluate the effects of self-administered intracavernosal injection of alprostadil for erectile dysfunction, when used for up to 18 months during a 13 country Phase III clinical trial. METHODS:The Duke Health Profile was used to measure patients' physical and psychoso...
journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章
doi:10.1038/sj.ijir.3900364
更新日期:1998-12-01 00:00:00
abstract::New Zealand white rabbit cavernosal smooth muscle strips (n=6) were mounted in organ baths. Relaxations to nitric oxide (10(-7)-10(-4) mol/l) were measured and the same procedure was repeated on strips from rabbits 6 months after alloxan-induced diabetes (n=6). Transverse cavernosal sections were obtained from the sam...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900935
更新日期:2002-12-01 00:00:00
abstract::Erectile dysfunction (ED) develops owing to psychogenic, organic or/and both of these two factors. The aim of this study was to investigate the relationship between penile cavernosal arterial flow and peripheral atherosclerosis in men with ED. This study was conducted on 102 patients who had presented to Radiology Cli...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2013.35
更新日期:2014-03-01 00:00:00
abstract::Although decline in sexual function is a common reason for ageing men to seek advice regarding testosterone therapy, placebo-controlled trial data have been unable to show a consistent, beneficial role for testosterone. The objective of this study was to determine the effect of testosterone therapy on sexual function ...
journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
doi:10.1038/ijir.2008.22
更新日期:2008-07-01 00:00:00
abstract::Hypercholesterolemia is a major risk factor for erectile dysfunction. To understand the mechanism(s) of hypercholesterolemia-induced erectile dysfunction, we studied the effect of lysophosphatidylcholine (LPC) on the membrane conductance of corporal smooth muscle cells. We used cultured human corporal smooth muscle ce...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901356
更新日期:2005-11-01 00:00:00
abstract::Both overweight and obesity have been identified as risk factors for sexual dysfunction in men, but the relationship between sexual function and amount of body fat in females is still obscure. There are few reported studies in women assessing the relationship between female sexual function index (FSFI) and body weight...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2010.7
更新日期:2010-07-01 00:00:00
abstract::Some autologous tissues can restore erectile function (EF) in rats after a resection of the cavernous nerve (CN). However, a cavernous nerve crush injury (CNCI) better reproduces ED occurring after a nerve-sparing radical prostatectomy (RP). The aim was to evaluate the effect on EF of an autologous vein graft after CN...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2014.32
更新日期:2015-03-01 00:00:00
abstract::Gynecomastia is an unusual side effect associated with testosterone replacement therapy (TRT) that has been traditionally treated with surgery, radiation, or discontinuation of testosterone supplementation. We report here our experience with two cases of gynecomastia in men undergoing TRT who were successfully treated...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901154
更新日期:2004-02-01 00:00:00
abstract::Hard flaccid (HF) is a group of symptoms that significantly affects a man's sexual and social life. As this syndrome has only been reported in several patient forums, exact prevalence of this rare condition is unknown. Currently, no scientific literature exists of the syndrome. We, hereby, aimed to present four cases ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/s41443-019-0133-z
更新日期:2020-03-01 00:00:00
abstract::Cross-linked dextran and polymethylmethacrylate mixture (Lipen-10) is newly developed tissue filler. The purpose of this study was to evaluate tolerability and efficacy of Lipen-10 on penile enhancement. Twenty adult males were included in this study. Lipen-10 was injected into the subcutaneous tissue of the penile sh...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2012.41
更新日期:2013-05-01 00:00:00
abstract::Penile intra-epithelial neoplasia (PeIN) is a known precursor for penile cancer. It may be undifferentiated or differentiated. The former is related to high-risk Human Papilloma Virus (HPV) and associated with p16 over-expression. Patients may present with red patches or lesions on the penis which on occasion may affe...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/s41443-020-0327-4
更新日期:2020-07-24 00:00:00
abstract::Sildenafil is one of two oral drugs approved for first-line treatment of erectile dysfunction (ED). Anecdotally, some young healthy men who wish to enhance their sexual performance are requesting or abusing sildenafil. In this randomized double-blind, placebo-controlled clinical study, we investigated the effect of si...
journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ijir.3901005
更新日期:2003-06-01 00:00:00