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Sildenafil does not improve sexual function in men without erectile dysfunction but does reduce the postorgasmic refractory time.

Abstract：

:Sildenafil is one of two oral drugs approved for first-line treatment of erectile dysfunction (ED). Anecdotally, some young healthy men who wish to enhance their sexual performance are requesting or abusing sildenafil. In this randomized double-blind, placebo-controlled clinical study, we investigated the effect of sildenafil in young men without ED. A total of 60 young healthy men age 20-40 y with no reported ED were enrolled for this single-dose home-use study. Subjects had used no medication in the 6 months prior to the study. All had been engaged in a stable relationship for at least 3 months. After completing the IIEF-5 questionnaire, patients were randomized in a double-blind fashion to receive either one 25 mg tablet of sildenafil (group 1) taken prior to intercourse, or an identical placebo tablet (group 2). All subjects completed a questionnaire relating to their erectile quality. There were no differences between the two groups in the reported improvement of erection quality, 12/30 sildenafil vs 10/30 placebo (Fisher's test, P=0.79). Sildenafil caused a significant reduction of the postejaculatory refractory time (12/30 vs 4/30) (chi(2) test, P=0.04). Sildenafil does not improve erections in young healthy men. Sildenafil should not be given to young healthy men to improve their erections and patients should be advised against recreational abuse of the drug. In this limited single-dose home study, sildenafil appears to reduce the postorgasmic refractory time. Although controlled studies are needed to evaluate the efficacy of erection-enhancing drugs in premature ejaculation, it is possible that sildenafil might be useful for this indication.

journal_name

Int J Impot Res

journal_title

International journal of impotence research

authors

Mondaini N,Ponchietti R,Muir GH,Montorsi F,Di Loro F,Lombardi G,Rizzo M

doi

10.1038/sj.ijir.3901005

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

225-8

issue

eissn

0955-9930

issn

1476-5489

pii

3901005

journal_volume

pub_type

临床试验,杂志文章,随机对照试验

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Sildenafil does not improve sexual function in men without erectile dysfunction but does reduce the postorgasmic refractory time.