Abstract:
:Erectile dysfunction is a common condition that affects men over age 40. It is highly related to obesity. The corpus cavernosum is the most important structure involved in erection. The aim of this study was to evaluate the structure of the corpus cavernosum of mice fed with a high energy density diet (HED). At 3 months of age, male C57BL/6 mice were fed with a HED diet (50% lipids) or standard chow (SC) diet (10% lipids) for 14 weeks. Afterwards, the animals were euthanized and the corpus cavernosum was analyzed through stereology. Statistical significance was calculated by the student's t-test (p < 0.05). The group fed with HED diet showed higher values of body weight, blood pressure and higher rates of cholesterol, triglycerides, and glucose from the second week to the end of the experiment. The HED group showed a significant increase in the connective tissue (15%) and a decrease in smooth muscle fibers (41%). The testosterone concentration in the HED group was 63% lower than in SC animals. Animals fed with a HED presented reduced testosterone serum levels and morphological changes on the corpus cavernosum, which may be related to erectile dysfunction.
journal_name
Int J Impot Resjournal_title
International journal of impotence researchauthors
Alves-Pereira JL,Frantz EDC,Pires LAS,Babinski MA,da Fonte Ramos Cdoi
10.1038/s41443-018-0089-4subject
Has Abstractpub_date
2019-03-01 00:00:00pages
126-131issue
2eissn
0955-9930issn
1476-5489pii
10.1038/s41443-018-0089-4journal_volume
31pub_type
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