Abstract：
:We studied the association between erythrocyte aggregation (EA) and erectile dysfunction (ED) in men with coronary artery disease (CAD). Men with CAD documented by coronary angiography filled the Sexual Health Inventory for Males questionnaire to detect ED and assess its severity. EA was evaluated by filming slides of blood smear. Low percentage of slide field covered by erythrocytes represented increased EA. Overall, 133 men with CAD, mean ages 62.4+/-12.2 years, were included: 100 (75.2%) with ED and 33 (24.8%) without ED. EA was increased among men with ED compared with men without ED (percentage of slide field covered by erythrocytes 66.7+/-14.7 vs 73.1+/-14.5%; P=0.03). After adjustment for age, diabetes mellitus, hemoglobin and hematocrit levels, EA was associated with ED severity (r=0.18; P=0.038). We conclude that EA is increased in men with CAD and ED. This finding may be relevant to the pathophysiology of ED in men with CAD.
journal_name
Int J Impot Resjournal_title
International journal of impotence researchauthors
Justo D,Mashav N,Arbel Y,Kinori M,Steinvil A,Swartzon M,Molat B,Halkin A,Finkelstein A,Heruti R,Banai Sdoi
10.1038/ijir.2009.6subject
Has Abstractpub_date
2009-05-01 00:00:00pages
192-7issue
3eissn
0955-9930issn
1476-5489pii
ijir20096journal_volume
21pub_type
杂志文章abstract：:In extracavernosal vascular tissue, smooth muscle tone is modulated by a balance between angiotensin II (Ang II) and nitric oxide (NO). We hypothesized that these substances also play an important role in regulating cavernosal smooth muscle contractility. We therefore studied the in vitro effects of an Ang II receptor...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3900261
更新日期：1997-09-01 00:00:00
abstract：:We describe a case of gunshot wound to the corpora cavernosa caused by a low-velocity bullet in a 43-year-old man. He volunteered that his lover's husband shot him with a handgun. The bullet had penetrated the right gluteal region with no exit wound causing a right corpus cavernosum lesion. A penile colour-duplex dopp...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901472
更新日期：2006-11-01 00:00:00
abstract：PURPOSE:Aim of this systematic review is to evaluate functional outcomes (Qmax, QoL, IPSS, PVR), sexual outcome (erectile dysfunction and anejaculation rate), and adverse events evaluated according to the Clavien-Dindo classification. METHODS:The bibliographic search with the included terms (prostate, benign prostatic...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/s41443-019-0158-3
更新日期：2019-11-01 00:00:00
abstract：:Unconsummated marriage (UM) is the failure to perform successful sexual intercourse at the beginning of the marriage. Vaginismus has been traditionally reported as the leading cause. ED is also a leading cause for UM. This appears to be a significant problem in the conservative middle-Eastern societies and in the deve...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2013.24
更新日期：2014-01-01 00:00:00
abstract：:Isometric tension measurement using a selective Rho-kinase inhibitor (+)- (R)-trans4-(1-aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide (Y-27632) and a selective myosin light chain kinase (MLCK) inhibitor 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML7) were used in rabbit clitoral caver...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3900911
更新日期：2002-12-01 00:00:00
abstract：:Even with the help of modern pharmacology, treatment of erectile dysfunction often remains complex, and requires taking into account the social, psychological, and behavioral dimensions of the disorder. This brief report presents a case study highlighting this complexity. ...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901322
更新日期：2005-07-01 00:00:00
abstract：:This study was conducted to determine rate and related factors of dyspareunia. Three hundred and nineteen women aged 15-49 years were surveyed. A questionnaire was used to collect data. Pelvic examinations and connective tissue disorders were investigated. At whole 54.5% had dyspareunia. The means of gravidity, parity...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901495
更新日期：2007-01-01 00:00:00
abstract：:Both RigiScan and the Snap Gauge band devices are used to objectively measure penile rigidity. The Snap Gauge band is the more simple and inexpensive of the two techniques. We investigated the correlation between the results obtained by both devices in order to evaluate whether the Snap Gauge band could be employed as...
journal_title：International journal of impotence research
pub_type： 临床试验,杂志文章
doi：10.1038/sj.ijir.3900438
更新日期：1999-12-01 00:00:00
abstract：:The effects of hypoxia (pO2: 50 mmHg), acidosis (pH: 6.9) or glucopenia (absence of glucose) in vitro on the tone of the rabbit corpus cavernosum were investigated. The recovery of smooth muscle contractility following exposure to these conditions was also assessed. Hypoxia, acidosis or glucopenia alone or in combinat...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901231
更新日期：2005-01-01 00:00:00
abstract：:We have investigated the reliability of intracavernosal prostaglandin E1 (PGE1) office vs self-injection therapy in patients with erectile dysfunction (ED). A total of 298 male patients with ED were enrolled in this study. In all patients, intracavernosal titration of the PGE1 dose was performed. A total of 106 patien...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901388
更新日期：2006-03-01 00:00:00
abstract：:The sympathetic nervous system is important for penile function: it mediates detumescence and may contribute to the maintenance of the penis in a non-erect state. The sympathetic preganglionic neurons are found in the intermediolateral gray matter of the spinal cord. Postganglionic neurons are located to the sympathet...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:Sildenafil citrate has been shown to be effective in a wide range of patients with erectile dysfunction and has been approved in the United States for this indication. The overall clinical safety of oral sildenafil, a potent inhibitor of phosphodiesterase type 5, in the treatment of erectile dysfunction was evaluated ...
journal_title：International journal of impotence research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ijir.3900354
更新日期：1998-06-01 00:00:00
abstract：:The objective was to investigate the cellular effect and action mechanism of Artemisia capillaris extract (ACE) and its component, scopoletin, on penile corpus cavernosum smooth muscle (PCCSM). In vitro study with PCCSM, the precontracted PCCSM with phenylephrine was treated with ACE or scopoletin. Cyclic nucleotides ...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2015.23
更新日期：2015-11-01 00:00:00
abstract：:Hypercholesterolemia is a major risk factor for erectile dysfunction. To understand the mechanism(s) of hypercholesterolemia-induced erectile dysfunction, we studied the effect of lysophosphatidylcholine (LPC) on the membrane conductance of corporal smooth muscle cells. We used cultured human corporal smooth muscle ce...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901356
更新日期：2005-11-01 00:00:00
abstract：:The objective of this study was to evaluate the effect on erections of impeding venous blood flow following intracavernosal injections of prostaglandin E1. Dispersion of injected X-ray contrast medium indicated that application of the RMRI penile clamp to the base of the penis retarded venous outflow. The clamp was th...
journal_title：International journal of impotence research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-03-01 00:00:00
abstract：:The transient receptor potential cationic channel type A1 (TRPA1), belonging to a superfamily of cationic membrane channels, has been suggested to act as mechano- and pain sensor and, thus, to play a role in neurotransmission in the human body, including the urogenital tract. While the expression of TRPA1 has been inv...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2014.23
更新日期：2015-01-01 00:00:00
abstract：:Penile intra-epithelial neoplasia (PeIN) is a known precursor for penile cancer. It may be undifferentiated or differentiated. The former is related to high-risk Human Papilloma Virus (HPV) and associated with p16 over-expression. Patients may present with red patches or lesions on the penis which on occasion may affe...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/s41443-020-0327-4
更新日期：2020-07-24 00:00:00
abstract：:Erectile dysfunction (ED), generally associated with reduced sexual desire and sometimes with orgasmic or ejaculatory dysfunction, is the major revealing symptom of hyperprolactinemia (HPRL) in men, a condition that should not be neglected since many cases result from pituitary tumors, likely to result in serious comp...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/sj.ijir.3901043
更新日期：2003-10-01 00:00:00
abstract：:Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) has long been used as a traditional Chinese medicine for dysfunctions of the endocrine system and inflammation conditions. However, the effect of adlay seed on the endocrine system has not yet been reported. In the present study, the effects and the mechanisms of metha...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3901405
更新日期：2006-05-01 00:00:00
abstract：:This cohort study aimed to assess the effect of the mode of delivery on female sexual function (FSF) after childbirth. Out of 256 primiparous women, 200 subjects that completed the study were divided into two groups; women that delivered vaginally and women that had elective cesarean section (CS). They were subjected ...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2015.2
更新日期：2015-05-01 00:00:00
abstract：:One of the most commonly used tests to distinguish psychogenic from organic erectile dysfunction (ED) is to monitor nocturnal penile tumescence using the RigiScan device and its new software called RigiScan Plus. To give a true estimate of the predictive ability of the new RigiScan software parameters, tumescence acti...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/ijir.2009.49
更新日期：2009-11-01 00:00:00
abstract：:Coronavirus disease 2019 (COVID-19) pandemic has been continuing to affect the lives of all people globally. It has been shown that restrictions due to changes in lifestyles lead to mental health problems. This study aims to investigate the effect of COVID-19 pandemic on couples' sexuality. A total of 245 volunteers (...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/s41443-020-00378-4
更新日期：2020-12-16 00:00:00
abstract：:Erectile dysfunction is a common disorder. However, not all dysfunctional men want to pursue evaluation. To delineate the characteristics of men interested in evaluation of erectile dysfunction, we conducted a mailed survey of 1031 randomly selected male veterans aged 30-99 years. We received 427 completed surveys. Us...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:The present study provides a review of stem cell therapy as a treatment of erectile dysfunction from peer-reviewed human and animal trials. A literature search was conducted in PubMed-Medline, Scopus, Embase, and Cochrane databases. Tweenty-three animal studies and seven human studies in the period from 1st of January...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/s41443-020-00406-3
更新日期：2021-01-15 00:00:00
abstract：:We investigated whether coronary flow reserve (CFR) can be modified by tadalafil, a long-acting phosphodiesterase 5 (PDE5) inhibitor, in patients with documented coronary artery disease (CAD). CFR was non-invasively evaluated in 12 men with a positive history for erectile dysfunction (ED) and angiographically document...
journal_title：International journal of impotence research
pub_type： 临床试验,杂志文章
doi：10.1038/sj.ijir.3901592
更新日期：2008-03-01 00:00:00
abstract：:Number of gender dysphoric people increased over the last few decades with positive social acceptance of transpopulation. Genital gender affirming surgeries are of utmost importance in order to adjust body to the mind of these individuals. Creation of the phallus is usually the last step in transmen transition, which ...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/s41443-020-00346-y
更新日期：2020-08-21 00:00:00
abstract：:Sildenafil citrate, marketed as Viagra, for the treatment of erectile dysfunction, has a proven record of safety in humans as predicted by the results of extensive pharmacological and toxicological testing in animals and in vitro, and confirmed by pharmacokinetic exposure data. The aim of this paper is to review succi...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/sj.ijir.3901232
更新日期：2004-12-01 00:00:00
abstract：:In a prospective, placebo-controlled, one group crossover design study, we tested whether adding programmed intracavernous PGE1 injections (IC-PGE1) can improve the effectiveness of sildenafil in erectile dysfunction (ED) patients unresponsive to monotherapy with this drug. In all, 40 ED patients who had experienced u...
journal_title：International journal of impotence research
pub_type： 临床试验,杂志文章
doi：10.1038/sj.ijir.3901290
更新日期：2005-07-01 00:00:00
abstract：:Hypogonadotropic patients may visit pediatricians, general practitioners, endocrinologists or urologists, presenting with microphallus, cryptochidism or pubertas tarda and delayed bone maturation. Congenital hypogonadotropic hypogonadism is characterized, apart from small testes, by the constellation of low serum leve...
journal_title：International journal of impotence research
pub_type： 杂志文章
doi：10.1038/sj.ijir.3900493
更新日期：2000-04-01 00:00:00
abstract：:Currently available agents for erectile dysfunction (ED) share the same mechanism of action and pharmacologic properties. Therefore, they share the same limitations, including a principal focus on erection as an end-organ process. One of the relatively unexplored areas of research has been the potential for centrally ...
journal_title：International journal of impotence research
pub_type： 杂志文章,评审
doi：10.1038/ijir.2008.18
更新日期：2008-07-01 00:00:00
