Abstract:
:The transient receptor potential cationic channel type A1 (TRPA1), belonging to a superfamily of cationic membrane channels, has been suggested to act as mechano- and pain sensor and, thus, to play a role in neurotransmission in the human body, including the urogenital tract. While the expression of TRPA1 has been investigated in a variety of tissues, up until today, no study has addressed the expression and distribution in the female genital tract. The present study aimed to investigate the expression and distribution of TRPA1 protein in human vaginal tissue. Reverse transcriptase PCR (RT-PCR) was applied in order to identify messenger ribonuleic acid specifically encoding for TRPA/A1. The distribution of TRPA1 in relation to the neuronal nitric oxide synthase (nNOS) and the signaling peptide calcitonin gene-related peptide (CGRP) was examined by means of immunohistochemical methods (double-antibody technique, laser fluorescence microscopy). RT-PCR analysis revealed the expression of mRNA encoding sequences specific for TRPA in the vaginal wall and epithelium. Immunostaining related to TRPA1 was observed in the basal epithelium and in slender varicose nerve fibers transversing the subepithelial and stromal space of the vaginal sections. In addition, these fibers presented immunoreactivity specific for nNOS or CGRP. The smooth musculature of the vaginal wall and small vessels interspersing the tissue did not present signals related to TRPA1. The findings indicate that TRPA1 might be involved in afferent neurotransmission in the vagina and work synergistically together with the nitric oxide/cyclic guanosine monophosphate pathway.
journal_name
Int J Impot Resjournal_title
International journal of impotence researchauthors
Ückert S,Sonnenberg JE,Albrecht K,Kuczyk MA,Hedlund Pdoi
10.1038/ijir.2014.23subject
Has Abstractpub_date
2015-01-01 00:00:00pages
16-9issue
1eissn
0955-9930issn
1476-5489pii
ijir201423journal_volume
27pub_type
杂志文章abstract::This work aimed to assess the cavernous anti-apoptotic role of using chronic low-dose sildenafil/tadalafil with and without testosterone (T) in aged diabetic rats. In all, 140 Sprague-Dawley aged rats were divided into the following groups: controls; induced diabetic rats; diabetic rats that received intramuscular dep...
journal_title:International journal of impotence research
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abstract::To date, no effective medical approach for the treatment of erectile dysfunction (ED) secondary to ischemic priapism (IP) has been described. The aim of this study was to evaluate the anti-inflammatory, antifibrotic, and antioxidant effects of pirfenidone (PFD) on cavernosal tissue in a rat model of IP. Forty-eight ma...
journal_title:International journal of impotence research
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abstract::Men with the metabolic syndrome demonstrate an increased prevalence of erectile dysfunction (ED). In the present study, we tested the effect of a Mediterranean-style diet on ED in men with the metabolic syndrome. Men were identified in our database of subjects participating in controlled trials evaluating the effect o...
journal_title:International journal of impotence research
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abstract::The objective of the study was to evaluate the relationship between the sexual position and severity of penile fracture (PF). We studied 90 patients with PF. The mechanism of injury and the sexual position was assessed. We divided our sample by the etiology of the fracture in six groups: (a) masturbation or penile man...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2017.24
更新日期:2017-09-01 00:00:00
abstract::Peyronie's disease (PD) is a condition characterized by localized and often progressive fibrosis and scarring of the penis. This condition has an unknown etiology although several hypotheses have been proposed. These include traumatic, immunologic and genetic causes. We studied the genetics and immunology of PD using ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900591
更新日期:2000-10-01 00:00:00
abstract::Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by parkinsonism and cerebellar, autonomic, urinary, and/or pyramidal dysfunction. Urinary and erectile dysfunction (ED) symptoms are prominent early features in men with MSA. Autonomic failure, considered until recently to be the ca...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901014
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abstract::The aim of the present study was to investigate which PD specific factors (e.g., degree of penile curvature, levels of pain) cause most distress and to further explore whether there are specific subgroups of patients that report particularly high levels of psychological distress. Data were available for N = 119 men wi...
journal_title:International journal of impotence research
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abstract:BACKGROUND:The objective was to collect characteristics of patients with male erectile disorder (MED) attending a male sexual dysfunction clinic and determine the level of psychological morbidity whilst recruiting subjects into a psychotherapy study. METHODS:This was a study of data of 132 patients diagnosed as having...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900295
更新日期:1997-12-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1038/s41443-019-0158-3
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abstract::Anxiety plays a major role in the development of the problems associated with erectile dysfunction (ED). Psychological and behavioural responses to ED can lead to a vicious cycle of increased uneasiness, distance and conflicts. This in turn leads to a lower frequency of sexual encounters, less time spent together and ...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/sj.ijir.3900994
更新日期:2003-04-01 00:00:00
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doi:10.1038/sj.ijir.3900865
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journal_title:International journal of impotence research
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doi:10.1038/sj.ijir.3900392
更新日期:1999-06-01 00:00:00
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doi:10.1038/sj.ijir.3900979
更新日期:2003-06-01 00:00:00
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doi:10.1038/s41443-020-00378-4
更新日期:2020-12-16 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900825
更新日期:2002-06-01 00:00:00
abstract::This prospective study determined the rate of abandonment of sildenafil therapy and assessed the reasons for abandonment. Between January 2001 and December 2002, 234 patients with erectile dysfunction (ED) at three independent centers successfully began therapy with sildenafil 50 or 100 mg. The rate of noncompliance w...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901252
更新日期:2005-01-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
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journal_title:International journal of impotence research
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doi:10.1038/sj.ijir.3901373
更新日期:2006-03-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901231
更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.ijir.3900374
更新日期:1999-02-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901041
更新日期:2003-10-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900838
更新日期:2002-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
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更新日期:2003-02-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/s41443-020-00406-3
更新日期:2021-01-15 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
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更新日期:2012-11-01 00:00:00