Abstract:
:Some autologous tissues can restore erectile function (EF) in rats after a resection of the cavernous nerve (CN). However, a cavernous nerve crush injury (CNCI) better reproduces ED occurring after a nerve-sparing radical prostatectomy (RP). The aim was to evaluate the effect on EF of an autologous vein graft after CNCI, compared with an artificial conduit. Five groups of rats were studied: those with CN exposure, exposure+vein, crush, crush+guide and crush+vein. Four weeks after surgery, the EF of rats was assessed by electrical stimulation of the CNs. The intracavernous pressure (ICP) and mean arterial pressure (MAP) were monitored during stimulations at various frequencies. The main outcome, that is, the rigidity of the erections, was defined as the ICP/MAP ratio. At 10 Hz, the ICP/MAP ratios were 41.8%, 34.7%, 20.9%, 33.9% and 20.5%, respectively. The EF was significantly lower in rats if the CNCI was treated with a vein graft instead of an artificial guide. Contrary to cases of CN resection, autologous vein grafts did not improve EF after CNCI. In terms of clinical use, the study suggests to limit an eventual use of autologous vein grafts to non-nerve-sparing RPs.
journal_name
Int J Impot Resjournal_title
International journal of impotence researchauthors
Bessede T,Moszkowicz D,Alsaid B,Zaitouna M,Diallo D,Peschaud F,Benoit G,Droupy Sdoi
10.1038/ijir.2014.32subject
Has Abstractpub_date
2015-03-01 00:00:00pages
59-62issue
2eissn
0955-9930issn
1476-5489pii
ijir201432journal_volume
27pub_type
杂志文章abstract::Promescent is a lidocaine-based ejaculation delaying spray that absorbs into the skin of the penis prior to sexual activity. This article aimed to evaluate the effect of Promescent on the experience of orgasm, ejaculatory latency time and quality of sexual experience (QSE). Additionally, we assessed ease of applicatio...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2016.31
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The objective was to collect characteristics of patients with male erectile disorder (MED) attending a male sexual dysfunction clinic and determine the level of psychological morbidity whilst recruiting subjects into a psychotherapy study. METHODS:This was a study of data of 132 patients diagnosed as having...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900295
更新日期:1997-12-01 00:00:00
abstract::Early pharmacological prophylaxis has been reported to increase the return of spontaneous erections following radical prostatectomy (RP). In this study, we evaluated the role of intracavernosal alprostadil (PGE1) combined with sildenafil in stimulating early recovery of spontaneous erections following RP. In this pros...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901448
更新日期:2006-09-01 00:00:00
abstract::The objective was to describe funding sources and publication trends for the primary literature on Peyronie's disease (PD), including direct industry research support. A search of EMBASE, PubMed, Scopus, and Web of Science was performed to identify articles published from 2006 to 2018. Articles not published in Englis...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/s41443-020-0244-6
更新日期:2021-01-01 00:00:00
abstract::The activation of cavernous local renin-angiotensin system has an important role in pathogenesis of diabetic erectile dysfunction (ED). In our primary study, we found that angiotensin Type 1 receptor blocker improved the erectile function of diabetic rats. Therefore we explored the losartan in clinical treatment for d...
journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
doi:10.1038/ijir.2012.4
更新日期:2012-11-01 00:00:00
abstract::Erectile dysfunction (ED) is linked to various cardiovascular risk factors and may therefore serve as a predictor of cardiovascular events. To gain further insight into this relationship, we reviewed all data regarding hospital admission for cardial or cerebral vascular disease that occurred until 2008 in a cohort of ...
journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
doi:10.1038/ijir.2009.40
更新日期:2010-01-01 00:00:00
abstract::Tunica albuginea (TA) of the penis, which has an important role in mechanism of erection, is composed mainly of collagen bundles. Both aging and diabetes mellitus (DM) were reported to be associated with many alterations in collagen content and architecture in several body tissues. So, the aim of this work was to eval...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900389
更新日期:1999-04-01 00:00:00
abstract::Although decline in sexual function is a common reason for ageing men to seek advice regarding testosterone therapy, placebo-controlled trial data have been unable to show a consistent, beneficial role for testosterone. The objective of this study was to determine the effect of testosterone therapy on sexual function ...
journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
doi:10.1038/ijir.2008.22
更新日期:2008-07-01 00:00:00
abstract::The human T-lymphotropic virus type I (HTLV-I) is a retrovirus associated with a chronic myelopathy known as HTLV-I-Associated Myelopathy or Tropical Spastic Paraparesis (HAM/TSP). The main objective was to assess the frequency of erectile dysfunction (ED) in HTLV-I-infected individuals from Salvador and other cities ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901335
更新日期:2005-07-01 00:00:00
abstract::Erectile dysfunction (ED) due to androgen deficiency is rare in the young population. We retrospectively evaluated in this study men aged 18-40 years presenting with ED from 2015 to 2017. The International Index of Erectile Function-5 (IIEF-5) and Erection Hardness Grade Scores (EHGS) were used to assess erectile func...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/s41443-018-0090-y
更新日期:2019-03-01 00:00:00
abstract::Even with the help of modern pharmacology, treatment of erectile dysfunction often remains complex, and requires taking into account the social, psychological, and behavioral dimensions of the disorder. This brief report presents a case study highlighting this complexity. ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901322
更新日期:2005-07-01 00:00:00
abstract::The aim of this study is to review the current literature that reports outcomes of Peyronie's disease (PD) grafting surgery, with a special focus on novel approaches and grafting materials. For this purpose, a literature review was performed through PubMed between 2014 and 2019 regarding grafting techniques in PD reco...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/s41443-019-0179-y
更新日期:2020-01-01 00:00:00
abstract::Phosphodiesterase 5 (PDE5) inhibitors are efficacious in treating patients with erectile dysfunction. New PDE5 inhibitors with different selectivity and pharmacokinetic profiles have been vigorously pursued. Here we report two novel, potent, and selective PDE5 inhibitors, JNJ-10280205 and JNJ-10287069, with Ki values ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901462
更新日期:2006-09-01 00:00:00
abstract::The imbalance between vasoconstrictors and vasodilators may play an important role in the pathogenesis of erectile dysfunction (ED). A total of 36 patients with ED, organogenic [diabetic (n=12) and nondiabetic (n=12)] and psychogenic (n=12) etiology, and 12 healthy adult men as controls were included. The levels of en...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901059
更新日期:2003-12-01 00:00:00
abstract::The purpose of this study is to investigate and compare the effects of 5-mg once-daily tadalafil versus 5-mg alternate-day tadalafil in men with moderate-to-severe erectile dysfunction (ED) and lower urinary tract symptoms (LUTS). Between January 2012 and June 2013, 144 men presenting with an International Index of Er...
journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
doi:10.1038/ijir.2014.19
更新日期:2015-01-01 00:00:00
abstract::Radical prostatectomy (RP) is a commonly performed procedure for the management of prostate cancer. While documented oncologic outcome for early stage disease is excellent, functional impairments such as incontinence and erectile dysfunction (ED) are common after the procedure. Recent evidence has implicated cavernous...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/ijir.2011.26
更新日期:2011-09-01 00:00:00
abstract::We estimated the incidence of erectile dysfunction (ED) in a population-based sample during 5-y follow-up and determined how the rate was affected by sociodemographic and life-style factors. The target population comprised all men aged 50, 60 or 70 y residing in the city of Tampere or 11 surrounding municipalities in ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901196
更新日期:2004-10-01 00:00:00
abstract::Apprehension about the normal size of penis is a major concern for men. Aim of the present investigation is to estimate the penile length and circumference of Indian males and to compare the results with the data from other countries. Results will help in counseling the patients worried about the penile size and seeki...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901569
更新日期:2007-11-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/ijir.2011.45
更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1038/sj.ijir.3901232
更新日期:2004-12-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2010.7
更新日期:2010-07-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/s41443-019-0214-z
更新日期:2020-09-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2012.41
更新日期:2013-05-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900890
更新日期:2002-08-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901341
更新日期:2005-09-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-03-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2016.6
更新日期:2016-05-01 00:00:00
abstract::There is considerable interest in understanding the genetics of erectile dysfunction (ED). Since early twin studies that suggested a genetic component to ED, multiple candidate gene studies have identified genetic variants that may be associated with ED. Genome-wide association studies (GWAS) have overcome some of the...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
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更新日期:2020-11-10 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901580
更新日期:2008-03-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00