Abstract:
:The first goal of this study was to examine the effect of secondhand smoking on neurogenic, endothelium- and cGMP-dependent relaxant responses of rabbit corpus cavernosum smooth muscle. Our second goal was to determine whether such an effect can be prevented by oral administration of L-arginine. Male New Zealand rabbits were divided into control, chronic passive cigarette smoking and L-arginine treatment groups. Relaxant or contractile responses in isolated corpus cavernosum smooth muscle strips were determined by using in vitro muscle technique. There was no significant difference in the relaxant response of the strips to papaverine, sodium nitroprusside and contractile response to KCl among the groups. Relaxant responses to acetylcholine and electrical field stimulation and contractile response to phenylephrine were significantly decreased in the strips of the smoking group than that of the control group. The impaired relaxations of strips were markedly improved by treatment of L-arginine, but the contractile responses to phenylephrine were not affected. These data indicate that secondhand smoking may impair both neurogenic and endothelium-dependent relaxation of corpus cavernosum smooth muscle, and may contribute to the etiology of impotence. Chronic dietary supplementation with L-arginine offsets the impairment of neurogenic and endothelial relaxation. Therefore, we suggest that secondhand smoking exposure to cigarette produces selective impairment of neurogenic and endothelium-dependent relaxation of corpus cavernosum smooth muscle via a mechanism related to the decreased production and/or availability of nitric oxide.
journal_name
Int J Impot Resjournal_title
International journal of impotence researchauthors
Göçmez SS,Utkan T,Duman C,Yildiz F,Ulak G,Gacar MN,Erden Fdoi
10.1038/sj.ijir.3901341subject
Has Abstractpub_date
2005-09-01 00:00:00pages
437-44issue
5eissn
0955-9930issn
1476-5489pii
3901341journal_volume
17pub_type
杂志文章abstract::One of the most commonly used tests to distinguish psychogenic from organic erectile dysfunction (ED) is to monitor nocturnal penile tumescence using the RigiScan device and its new software called RigiScan Plus. To give a true estimate of the predictive ability of the new RigiScan software parameters, tumescence acti...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2009.49
更新日期:2009-11-01 00:00:00
abstract::In extracavernosal vascular tissue, smooth muscle tone is modulated by a balance between angiotensin II (Ang II) and nitric oxide (NO). We hypothesized that these substances also play an important role in regulating cavernosal smooth muscle contractility. We therefore studied the in vitro effects of an Ang II receptor...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900261
更新日期:1997-09-01 00:00:00
abstract::This prospective study determined the rate of abandonment of sildenafil therapy and assessed the reasons for abandonment. Between January 2001 and December 2002, 234 patients with erectile dysfunction (ED) at three independent centers successfully began therapy with sildenafil 50 or 100 mg. The rate of noncompliance w...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901252
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The objective was to collect characteristics of patients with male erectile disorder (MED) attending a male sexual dysfunction clinic and determine the level of psychological morbidity whilst recruiting subjects into a psychotherapy study. METHODS:This was a study of data of 132 patients diagnosed as having...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900295
更新日期:1997-12-01 00:00:00
abstract::The study objective was to evaluate the efficacy of changing testosterone gel preparations among suboptimally responsive hypogonadal men. The records of all hypogonadal men on gel (Testim or Androgel) testosterone replacement therapy (TRT) were reviewed to identify men who underwent a brand substitution in gel TRT due...
journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章
doi:10.1038/sj.ijir.3901618
更新日期:2008-03-01 00:00:00
abstract::Psoriasis is a chronic inflammatory skin disease and seems to be associated with erectile dysfunction (ED). ED is a predictor of future cardiovascular disease. It is important to identify ED early and investigate cardiovascular problems in psoriasis patients. The sample consisted of 191 psoriasis patients and 191 heal...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2016.6
更新日期:2016-05-01 00:00:00
abstract::Although decline in sexual function is a common reason for ageing men to seek advice regarding testosterone therapy, placebo-controlled trial data have been unable to show a consistent, beneficial role for testosterone. The objective of this study was to determine the effect of testosterone therapy on sexual function ...
journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
doi:10.1038/ijir.2008.22
更新日期:2008-07-01 00:00:00
abstract::This discussion summarizes the potential differences in physiologically and pharmacologically induced erections and highlights the possible differences in the pathways facilitated by oral versus intracavernosal agents in penile erection. Oral agents act in conjunction with sexual stimulation either increasing corporal...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::Inflatable penile prosthesis (IPP) is an effective treatment for erectile dysfunction refractory to nonsurgical management. The infrapubic approach for IPP placement is less frequently employed than the penoscrotal approach, with only about 25% of IPPs placed via this method. Underutilization of the infrapubic method ...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/s41443-019-0193-0
更新日期:2020-01-01 00:00:00
abstract::At this present time there is a serious gap in our understanding of how psychological difficulties result in specific sexual dysfunction. In this paper, a theoretical model of sexual response is proposed which involves the parallel existence of excitatory and inhibitory mechanisms in the central nervous system. Eviden...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:
更新日期:1998-05-01 00:00:00
abstract::The role of steroid hormones in regulating vaginal smooth muscle contractility was investigated. Rabbits were kept intact or ovariectomized. After 2 weeks, animals were continuously infused with vehicle or supraphysiological levels of testosterone (100 microg/day), or estradiol (200 microg/day), for an additional 2 we...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901138
更新日期:2004-02-01 00:00:00
abstract::The diagnosis and classification of female sexual disorders has undergone significant changes over the last fifty years as a function of changing societal expectations for female sexual conduct, available knowledge about sexual psychophysiology and actual clinical practice. Currently, female sexual disorders are conce...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1201/b14618-47
更新日期:1998-05-01 00:00:00
abstract::This work aimed to assess the cavernous anti-apoptotic role of using chronic low-dose sildenafil/tadalafil with and without testosterone (T) in aged diabetic rats. In all, 140 Sprague-Dawley aged rats were divided into the following groups: controls; induced diabetic rats; diabetic rats that received intramuscular dep...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2010.12
更新日期:2010-07-01 00:00:00
abstract::Sildenafil citrate has been shown to be effective in a wide range of patients with erectile dysfunction and has been approved in the United States for this indication. The overall clinical safety of oral sildenafil, a potent inhibitor of phosphodiesterase type 5, in the treatment of erectile dysfunction was evaluated ...
journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ijir.3900354
更新日期:1998-06-01 00:00:00
abstract::The aim of the study was to determine whether any difference would occur in peak systolic velocity (PSV) and end diastolic velocity (EDV) measurements of color Doppler ultrasonography (CDU) between proximal and distal segments of the cavernous arteries obtained at different times. Twenty-six cases have undergone CDU t...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900304
更新日期:1998-03-01 00:00:00
abstract::Radical prostatectomy (RP) is a commonly performed procedure for the management of prostate cancer. While documented oncologic outcome for early stage disease is excellent, functional impairments such as incontinence and erectile dysfunction (ED) are common after the procedure. Recent evidence has implicated cavernous...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/ijir.2011.26
更新日期:2011-09-01 00:00:00
abstract::The sympathetic nervous system is important for penile function: it mediates detumescence and may contribute to the maintenance of the penis in a non-erect state. The sympathetic preganglionic neurons are found in the intermediolateral gray matter of the spinal cord. Postganglionic neurons are located to the sympathet...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::Erectile dysfunction (ED), generally associated with reduced sexual desire and sometimes with orgasmic or ejaculatory dysfunction, is the major revealing symptom of hyperprolactinemia (HPRL) in men, a condition that should not be neglected since many cases result from pituitary tumors, likely to result in serious comp...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/sj.ijir.3901043
更新日期:2003-10-01 00:00:00
abstract::Defining the minimal clinically meaningful improvement (MCMI) is crucial to understanding the treatment effects on health-status measures. We estimated the MCMI on the quality of erection questionnaire (QEQ), a validated measure specific to assess erectile quality during sexual intercourse. Data were from two controll...
journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
doi:10.1038/ijir.2009.47
更新日期:2010-01-01 00:00:00
abstract::The aim of this work was to characterize the effect of experimental diabetes on neurotransmission in rat vagina. Female Sprague-Dawley rats were divided into two groups: non-diabetic controls (NDM, n=38) and diabetics (DM, n=38). DM was produced by intraperitoneal injection of streptozotocin. Eight weeks later the ani...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900648
更新日期:2001-04-01 00:00:00
abstract::There is considerable interest in understanding the genetics of erectile dysfunction (ED). Since early twin studies that suggested a genetic component to ED, multiple candidate gene studies have identified genetic variants that may be associated with ED. Genome-wide association studies (GWAS) have overcome some of the...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/s41443-020-00372-w
更新日期:2020-11-10 00:00:00
abstract::From the files of the outpatient urology department 44 men with ED had undergone both psychophysiological diagnostic screening (PDS, VSS, VSS+VIB, ICI+VSS+VIB) and color Doppler sonography testing (CDS, including VSS). PDS was carried out by one medical physiologist, CDS by one urologist. The diagnoses reached could b...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900838
更新日期:2002-06-01 00:00:00
abstract::Sexual dysfunction is a common problem of increasing incidence that is associated with multiple co-morbid conditions and chronic diseases. In heart failure, however, exact numbers are unknown, in part secondary to under-reporting and under-interrogating by health care providers. A gender-specific questionnaire was mod...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901613
更新日期:2008-01-01 00:00:00
abstract::Several analyses have demonstrated a clinically useful relationship between serum prostate specific antigen (PSA) and prostate volume in men with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Both prostate volume and serum PSA predict certain aspects of the natural history of LUTS and BPH...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/ijir.2008.53
更新日期:2008-12-01 00:00:00
abstract::Both RigiScan and the Snap Gauge band devices are used to objectively measure penile rigidity. The Snap Gauge band is the more simple and inexpensive of the two techniques. We investigated the correlation between the results obtained by both devices in order to evaluate whether the Snap Gauge band could be employed as...
journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章
doi:10.1038/sj.ijir.3900438
更新日期:1999-12-01 00:00:00
abstract::Development and maintenance of penile erection requires the relaxation of the smooth muscle cells in the cavernous bodies and is essentially mediated by nitric oxide (NO). The penile flaccid state is conversely maintained by the alpha adrenergic neuroeffector system and by other vasoconstrictors, such as endothelin-1 ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900890
更新日期:2002-08-01 00:00:00
abstract::A prospective study was done on 76 patients who underwent surgical correction by corporeal plication of the penile deformity secondary to Peyronie's disease. Nocturnal penile tumescence and rigidity were recorded by RigiScan during three consecutive nights, before and after the operation. A significant number of patie...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::We estimated the incidence of erectile dysfunction (ED) in a population-based sample during 5-y follow-up and determined how the rate was affected by sociodemographic and life-style factors. The target population comprised all men aged 50, 60 or 70 y residing in the city of Tampere or 11 surrounding municipalities in ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901196
更新日期:2004-10-01 00:00:00
abstract::This cohort study aimed to assess the effect of the mode of delivery on female sexual function (FSF) after childbirth. Out of 256 primiparous women, 200 subjects that completed the study were divided into two groups; women that delivered vaginally and women that had elective cesarean section (CS). They were subjected ...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2015.2
更新日期:2015-05-01 00:00:00
abstract::A total of 76 male patients on renal replacement therapy (RRT) were investigated. Erectile dysfunction (ED) was defined as insufficient erection during visual erotic stimulation (VES) or during sleep as measured with Rigiscan and Erectiometer. Data on medical history, physical examination, and laboratory variables wer...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900946
更新日期:2003-02-01 00:00:00