The utility of serum prostatic-specific antigen in the management of men with benign prostatic hyperplasia.


:Several analyses have demonstrated a clinically useful relationship between serum prostate specific antigen (PSA) and prostate volume in men with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Both prostate volume and serum PSA predict certain aspects of the natural history of LUTS and BPH, and men with higher PSA and larger glands in general have a higher rate of progression measured by various parameters. Serum PSA also predicts the response to certain types of medical therapy in men with LUTS and BPH and is thus useful in the evaluation and management of these patients. Lastly, serum PSA does not loose its usefulness as a cancer marker for prostate cancer even if certain medications reduce serum PSA values predictably by 50%.


Int J Impot Res


Roehrborn CG




Has Abstract


2008-12-01 00:00:00










20 Suppl 3


  • Nocturnal penile erections: the diagnostic value of tumescence and rigidity activity units.

    abstract::One of the most commonly used tests to distinguish psychogenic from organic erectile dysfunction (ED) is to monitor nocturnal penile tumescence using the RigiScan device and its new software called RigiScan Plus. To give a true estimate of the predictive ability of the new RigiScan software parameters, tumescence acti...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Elhanbly S,Elkholy A,Elbayomy Y,Elsaid M,Abdel-gaber S

    更新日期:2009-11-01 00:00:00

  • Prevalence of erectile dysfunction and its correlates in Egypt: a community-based study.

    abstract::We evaluated the prevalence of erectile dysfunction (ED) in a cross-sectional community-based random sample of Egyptian men. ED was correlated with the socioeconomic status, risk factors and quality of life. Married men in Ismailia province were interviewed at home. Data were processed for 805 men with mean age of 43....

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Seyam RM,Albakry A,Ghobish A,Arif H,Dandash K,Rashwan H

    更新日期:2003-08-01 00:00:00

  • Additive effects of Artemisia capillaris extract and scopoletin on the relaxation of penile corpus cavernosum smooth muscle.

    abstract::The objective was to investigate the cellular effect and action mechanism of Artemisia capillaris extract (ACE) and its component, scopoletin, on penile corpus cavernosum smooth muscle (PCCSM). In vitro study with PCCSM, the precontracted PCCSM with phenylephrine was treated with ACE or scopoletin. Cyclic nucleotides ...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Choi BR,Kumar SK,Zhao C,Zhang LT,Kim CY,Lee SW,Jeon JH,Soní KK,Kim SH,Park NC,Kim HK,Park JK

    更新日期:2015-11-01 00:00:00

  • Effects of diabetes on neurotransmission in rat vaginal smooth muscle.

    abstract::The aim of this work was to characterize the effect of experimental diabetes on neurotransmission in rat vagina. Female Sprague-Dawley rats were divided into two groups: non-diabetic controls (NDM, n=38) and diabetics (DM, n=38). DM was produced by intraperitoneal injection of streptozotocin. Eight weeks later the ani...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Giraldi A,Persson K,Werkström V,Alm P,Wagner G,Andersson KE

    更新日期:2001-04-01 00:00:00

  • Why do patients with erectile dysfunction abandon effective therapy with sildenafil (Viagra)?

    abstract::This prospective study determined the rate of abandonment of sildenafil therapy and assessed the reasons for abandonment. Between January 2001 and December 2002, 234 patients with erectile dysfunction (ED) at three independent centers successfully began therapy with sildenafil 50 or 100 mg. The rate of noncompliance w...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Klotz T,Mathers M,Klotz R,Sommer F

    更新日期:2005-01-01 00:00:00

  • Open-label sildenafil treatment of partial and non-responders to double-blind treatment in men with antidepressant-associated sexual dysfunction.

    abstract::Fifty partial and non-responders (Clinical Global Impression-Sexual Function (CGI-SF) score>2), out of 76 men who completed a 6-week, double-blind, placebo-controlled trial of sildenafil treatment for serotonergic antidepressant-associated sexual dysfunction, were eligible for an additional 6-week trial of open-label ...

    journal_title:International journal of impotence research

    pub_type: 杂志文章,随机对照试验


    authors: Nurnberg HG,Fava M,Gelenberg AJ,Hensley PL,Paine S

    更新日期:2007-03-01 00:00:00

  • Male erectile disorder: characteristics and treatment choice of a longitudinal cohort study of men.

    abstract:BACKGROUND:The objective was to collect characteristics of patients with male erectile disorder (MED) attending a male sexual dysfunction clinic and determine the level of psychological morbidity whilst recruiting subjects into a psychotherapy study. METHODS:This was a study of data of 132 patients diagnosed as having...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Wylie KR

    更新日期:1997-12-01 00:00:00

  • Event-level impact of Promescent on quality of sexual experience in men with subjective premature ejaculation.

    abstract::Promescent is a lidocaine-based ejaculation delaying spray that absorbs into the skin of the penis prior to sexual activity. This article aimed to evaluate the effect of Promescent on the experience of orgasm, ejaculatory latency time and quality of sexual experience (QSE). Additionally, we assessed ease of applicatio...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Mark KP,Kerner I

    更新日期:2016-11-01 00:00:00

  • Bisphenol A inhibits penile erection via alteration of histology in the rabbit.

    abstract::Despite extensive research into the toxicity of bisphenol A (BPA), no report of its effect on erectile function exists. We performed this study to investigate the effect of BPA on erectile function. New Zealand white rabbits were treated intraperitoneally with 150 mg/kg of BPA every other day for 12 days (cumulative d...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Moon DG,Sung DJ,Kim YS,Cheon J,Kim JJ

    更新日期:2001-10-01 00:00:00

  • Central control and inhibitory mechanisms in male sexual response.

    abstract::At this present time there is a serious gap in our understanding of how psychological difficulties result in specific sexual dysfunction. In this paper, a theoretical model of sexual response is proposed which involves the parallel existence of excitatory and inhibitory mechanisms in the central nervous system. Eviden...

    journal_title:International journal of impotence research

    pub_type: 杂志文章,评审


    authors: Bancroft J

    更新日期:1998-05-01 00:00:00

  • New directions for erectile dysfunction therapies.

    abstract::Research in the field of erectile function and dysfunction has continued to expand rapidly. Based on the information available, some directions for future erectile dysfunction therapies can be identified. The first direction is improvement of current therapeutic principles. A second generation of orally active phospho...

    journal_title:International journal of impotence research

    pub_type: 杂志文章,评审


    authors: Andersson KE,Hedlund P

    更新日期:2002-02-01 00:00:00

  • Clinical trial update on shockwave therapy and future of erectile function restoration.

    abstract::Our interim analysis of a phase II clinical trial on low-intensity extracorporeal shockwave therapy (Li-ESWT) for men with erectile dysfunction (ED) has demonstrated it is safe with no reported adverse outcomes. Interim analysis has demonstrated Sexual Encounter Profile 3 (ability to maintain erection till completion)...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Patel P,Huang C,Molina M,Ramasamy R

    更新日期:2019-05-01 00:00:00

  • Peyronie's disease fibroblasts demonstrate tumorigenicity in the severe combined immunodeficient (SCID) mouse model.

    abstract::Peyronie's disease is a localized connective tissue disorder, caused by trauma to the erect penis, which results in cellular proliferation and excess extracellular matrix production within the tunica albuginea of the penis. We have previously demonstrated that cells derived from Peyronie's disease plaque tissue demons...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Mulhall JP,Martin DJ,Lubrano T,Moser M,Kwon E,Wojcik E,Shankey TV

    更新日期:2004-04-01 00:00:00

  • Spontaneous tumescence after implantation of three-piece hydraulic penile prostheses: a short-term experience.

    abstract::We evaluated spontaneous tumescence after penile prostheses implantation in a retrospective study. A total of 32 patients with three-piece hydraulic implants (17 Mentor Alpha I, 15 AMS Ultrex Plus) were enrolled. Consultation, personal interviews and questionnaires for both the patients and their partners provided the...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Manning M,Martínez FJ,Alken P,Jünemann KP

    更新日期:2003-06-01 00:00:00

  • NCX-911, a novel nitric oxide-releasing PDE5 inhibitor relaxes rabbit corpus cavernosum in the absence of endogenous nitric oxide.

    abstract::Phosphodiesterase type 5 (PDE5) inhibitors have reduced efficacy in treating erectile dysfunction (ED) in conditions where there is a lack of endogenous nitric oxide (NO). Therefore, NO-releasing PDE5 inhibitors have been developed. Here we report the effect of such a compound, NCX-911, on the tone and nitrergic relax...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Kalsi JS,Kell PD,Cellek S,Ralph DJ

    更新日期:2004-04-01 00:00:00

  • Hard flaccid syndrome: initial report of four cases.

    abstract::Hard flaccid (HF) is a group of symptoms that significantly affects a man's sexual and social life. As this syndrome has only been reported in several patient forums, exact prevalence of this rare condition is unknown. Currently, no scientific literature exists of the syndrome. We, hereby, aimed to present four cases ...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Gul M,Towe M,Yafi FA,Serefoglu EC

    更新日期:2020-03-01 00:00:00

  • Role of regenerative therapies on erectile dysfunction after radical prostatectomy.

    abstract::The present study provides a review of stem cell therapy as a treatment of erectile dysfunction from peer-reviewed human and animal trials. A literature search was conducted in PubMed-Medline, Scopus, Embase, and Cochrane databases. Tweenty-three animal studies and seven human studies in the period from 1st of January...

    journal_title:International journal of impotence research

    pub_type: 杂志文章,评审


    authors: Hansen ST,Lund M,Ostergaard LD,Lund L

    更新日期:2021-01-15 00:00:00

  • Effects of a high energy density diet in the "corpus cavernosum" of mice.

    abstract::Erectile dysfunction is a common condition that affects men over age 40. It is highly related to obesity. The corpus cavernosum is the most important structure involved in erection. The aim of this study was to evaluate the structure of the corpus cavernosum of mice fed with a high energy density diet (HED). At 3 mont...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Alves-Pereira JL,Frantz EDC,Pires LAS,Babinski MA,da Fonte Ramos C

    更新日期:2019-03-01 00:00:00

  • Expression and distribution of the transient receptor potential cationic channel ankyrin 1 (TRPA1) in the human vagina.

    abstract::The transient receptor potential cationic channel type A1 (TRPA1), belonging to a superfamily of cationic membrane channels, has been suggested to act as mechano- and pain sensor and, thus, to play a role in neurotransmission in the human body, including the urogenital tract. While the expression of TRPA1 has been inv...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Ückert S,Sonnenberg JE,Albrecht K,Kuczyk MA,Hedlund P

    更新日期:2015-01-01 00:00:00

  • Novel approaches and new grafting materials in Peyronie's disease reconstructive surgery.

    abstract::The aim of this study is to review the current literature that reports outcomes of Peyronie's disease (PD) grafting surgery, with a special focus on novel approaches and grafting materials. For this purpose, a literature review was performed through PubMed between 2014 and 2019 regarding grafting techniques in PD reco...

    journal_title:International journal of impotence research

    pub_type: 杂志文章,评审


    authors: Hatzichristodoulou G

    更新日期:2020-01-01 00:00:00

  • Measurement of erectile dysfunction in population-based studies: the use of a single question self-assessment in the Massachusetts Male Aging Study.

    abstract::A concise, reliable means of assessing erectile dysfunction (ED) in large, multidisciplinary population-based studies is needed. A single, direct question for self-assessed ED was assessed in the population-based sample of the Massachusetts Male Aging Study (MMAS). Of the 1156 respondents to the 1995-97 MMAS follow-up...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Derby CA,Araujo AB,Johannes CB,Feldman HA,McKinlay JB

    更新日期:2000-08-01 00:00:00

  • Penile implant infection prevention part II: device coatings have changed the game.

    abstract::The single most important factor in the reduction of penile implant infections has been the infection retardant coatings. Virtually every inflatable penile prosthesis (IPP) sold for the last 15 years in America has been coated and the device infection rate has dropped over 50% to less than 1% in experienced implanter ...

    journal_title:International journal of impotence research

    pub_type: 杂志文章,评审


    authors: Mulcahy JJ,Köhler TS,Wen L,Wilson SK

    更新日期:2020-08-07 00:00:00

  • Preservation of penile length after radical prostatectomy: early intervention with a vacuum erection device.

    abstract::Radical prostatectomy has been shown to have a potential negative impact on penile health. Stretched penile length (SPL), which most closely correlates with erect penile length, was significantly reduced in almost half of men undergoing surgery in several studies. The purpose of this study was to test whether early in...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Dalkin BL,Christopher BA

    更新日期:2007-09-01 00:00:00

  • Endothelium-dependency of yohimbine-induced corpus cavernosum relaxation.

    abstract::Development and maintenance of penile erection requires the relaxation of the smooth muscle cells in the cavernous bodies and is essentially mediated by nitric oxide (NO). The penile flaccid state is conversely maintained by the alpha adrenergic neuroeffector system and by other vasoconstrictors, such as endothelin-1 ...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Filippi S,Luconi M,Granchi S,Natali A,Tozzi P,Forti G,Ledda F,Maggi M

    更新日期:2002-08-01 00:00:00

  • Treatment of testosterone-induced gynecomastia with the aromatase inhibitor, anastrozole.

    abstract::Gynecomastia is an unusual side effect associated with testosterone replacement therapy (TRT) that has been traditionally treated with surgery, radiation, or discontinuation of testosterone supplementation. We report here our experience with two cases of gynecomastia in men undergoing TRT who were successfully treated...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Rhoden EL,Morgentaler A

    更新日期:2004-02-01 00:00:00

  • Increased estradiol levels in venous occlusive disorder: a possible functional mechanism of venous leakage.

    abstract::Venous insufficiency of the corpora cavernosa is the second most common cause of erectile dysfunction (ED). A functional insufficiency of the venous system has been hypothesised, but the cause is still unclear. To evaluate a possible endocrine mechanism, we have studied hormone profile in a group of nine patients with...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Mancini A,Milardi D,Bianchi A,Summaria V,De Marinis L

    更新日期:2005-05-01 00:00:00

  • Are medical students interested in sexual health education? A nationwide survey.

    abstract::The majority of medical students and medical healthcare providers do not feel comfortable when addressing sexual problems. It was suggested that more courses in sexual health are needed at medical schools to overcome this shortcoming. To assess medical students' interest in and attitude about sexual health education a...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Turner D,Nieder TO,Dekker A,Martyniuk U,Herrmann L,Briken P

    更新日期:2016-09-01 00:00:00

  • Method and design of drug treatment research of subjective premature ejaculation in men differs from that of lifelong premature ejaculation in males: proposal for a new objective measure (part 1).

    abstract::As lifelong premature ejaculation (PE) and subjective PE are two different PE subtypes, the measurement of their characteristic features requires different objective measures. In this article, we address the differences between lifelong PE and subjective PE, in terms of the extent of variation of sexual performance an...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Waldinger MD,Schweitzer DH

    更新日期:2019-09-01 00:00:00

  • Combining programmed intracavernous PGE1 injections and sildenafil on demand to salvage sildenafil nonresponders.

    abstract::In a prospective, placebo-controlled, one group crossover design study, we tested whether adding programmed intracavernous PGE1 injections (IC-PGE1) can improve the effectiveness of sildenafil in erectile dysfunction (ED) patients unresponsive to monotherapy with this drug. In all, 40 ED patients who had experienced u...

    journal_title:International journal of impotence research

    pub_type: 临床试验,杂志文章


    authors: Gutierrez P,Hernandez P,Mas M

    更新日期:2005-07-01 00:00:00

  • Screening for erectile dysfunction as part of periodic examination programs--concept and implementation.

    abstract::Erectile dysfunction (ED) can be an early and first sign of an underlying systemic disease. A screening program is offered by the Israeli Defense Force for career servicemen at the staff periodic examination center (SPEC), the aim of which was early detection of morbidity. We introduced the Sexual Human Inventory for ...

    journal_title:International journal of impotence research

    pub_type: 杂志文章


    authors: Heruti RJ,Yossef M,Shochat T

    更新日期:2004-08-01 00:00:00