Abstract:
:Erectile dysfunction (ED) due to androgen deficiency is rare in the young population. We retrospectively evaluated in this study men aged 18-40 years presenting with ED from 2015 to 2017. The International Index of Erectile Function-5 (IIEF-5) and Erection Hardness Grade Scores (EHGS) were used to assess erectile function. Total testosterone (TT), sex hormone-binding globulin (SHBG), lipid profile, and glycometabolic indicators were tested in fasting blood sample. TT and SHBG were detected by electrochemiluminescence immunoassay, and free (FT) and bio-available testosterone (BT) were calculated from a validated formula. Linear regression was used to analyze the data. In total, 140 cases (30.56 ± 4.81 years) with a mean TT levels of 6.15 ± 2.17 ng/ml were enrolled. Decreased levels of FT were associated with lower IIEF-5 scores(β = 0.176, P = 0.048) and EHGS (β = 0.198, P = 0.026) after adjustment for age, body mass index (BMI), smoking, comorbidities, high-sensitive C-reactive protein (hsCRP), uric acid, fructosamine, and quantitative insulin sensitivity check index (QUICKI). TT was only associated with EHGS in the crude model (β = 0.177, P = 0.037) and some single factor adjustment models, whereas BT and SHBG were not related with erectile function in any model. Low FT level, even in the presence of normal TT, is associated with ED severity in young men. FT levels should be screened in ED patient even with normal total testosterone.
journal_name
Int J Impot Resjournal_title
International journal of impotence researchauthors
Huang YP,Liu W,Chen SF,Liu YD,Chen B,Deng CH,Lu MJdoi
10.1038/s41443-018-0090-ysubject
Has Abstractpub_date
2019-03-01 00:00:00pages
132-138issue
2eissn
0955-9930issn
1476-5489pii
10.1038/s41443-018-0090-yjournal_volume
31pub_type
杂志文章abstract::The sympathetic nervous system is important for penile function: it mediates detumescence and may contribute to the maintenance of the penis in a non-erect state. The sympathetic preganglionic neurons are found in the intermediolateral gray matter of the spinal cord. Postganglionic neurons are located to the sympathet...
journal_title:International journal of impotence research
pub_type: 杂志文章
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更新日期:2000-03-01 00:00:00
abstract::Between December 1996 and December 1998, 79 inflatable penile implant insertions have been performed at our institution by a single surgeon. The objective of this analysis was to compare our in-patient and out-patient experience with penile prosthesis insertion with respect to ease of performance and complication prof...
journal_title:International journal of impotence research
pub_type: 杂志文章
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abstract::This cohort study aimed to assess the effect of the mode of delivery on female sexual function (FSF) after childbirth. Out of 256 primiparous women, 200 subjects that completed the study were divided into two groups; women that delivered vaginally and women that had elective cesarean section (CS). They were subjected ...
journal_title:International journal of impotence research
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901014
更新日期:2003-08-01 00:00:00
abstract::As lifelong premature ejaculation (PE) and subjective PE are two different PE subtypes, the measurement of their characteristic features requires different objective measures. In this article, we address the differences between lifelong PE and subjective PE, in terms of the extent of variation of sexual performance an...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/s41443-018-0107-6
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abstract::Considering the presence of dopaminergic receptors in the lumbosacral spinal cord, we tested whether apomorphine could exert a proerectile effect by acting at the spinal level. Intracavernous (ICP) and blood pressures (BP) were measured in anesthetized rats. ICP rises were quantified (duration, percentage of ICPmaximu...
journal_title:International journal of impotence research
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doi:10.1038/sj.ijir.3900654
更新日期:2001-04-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901157
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abstract::The aim of this work was to characterize the effect of experimental diabetes on neurotransmission in rat vagina. Female Sprague-Dawley rats were divided into two groups: non-diabetic controls (NDM, n=38) and diabetics (DM, n=38). DM was produced by intraperitoneal injection of streptozotocin. Eight weeks later the ani...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900648
更新日期:2001-04-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/s41443-019-0214-z
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journal_title:International journal of impotence research
pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901356
更新日期:2005-11-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901276
更新日期:2005-05-01 00:00:00
abstract::Physicians dealing with sexual dysfunction (SD) must consider the psychological and behavioral aspects of their patient's diagnosis and management, as well as organic causes and risk factors. Integrating sex therapy and other psychological techniques into their office practice will improve effectiveness in treating SD...
journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:10.1038/sj.ijir.3901075
更新日期:2003-10-01 00:00:00
abstract::A lack of uniformity exists for insurance payer coverage for all categories of penile prostheses (PP). We sought to determine common insurance coverage criteria and barriers to implantation across common insurance plans from healthcare referral regions (HRR) nationwide. Coverage criteria and stipulations were reviewed...
journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/s41443-019-0226-8
更新日期:2021-01-01 00:00:00
abstract::Several trials and reviews provide evidence for the efficacy of phosphodiesterase-5 inhibitors in the treatment of erectile dysfunction (ED). However, little is known about the impact of treatment effect modifiers other than concomitant diseases. Our objective was to identify patient and trial characteristics as well ...
journal_title:International journal of impotence research
pub_type: 杂志文章,meta分析
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更新日期:2006-11-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901287
更新日期:2005-05-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
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更新日期:2005-03-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章,评审
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更新日期:2011-09-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-06-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-03-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
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更新日期:2010-01-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901405
更新日期:2006-05-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3900946
更新日期:2003-02-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章,评审
doi:
更新日期:2000-03-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/ijir.2017.11
更新日期:2017-07-01 00:00:00
abstract::This randomized controlled cross-over study aimed to assess the efficacy and safety of glans penis injection with hyaluronic acid (HA) in treating premature ejaculation (PE). A total of 30 patients with PE were randomly allocated into two groups: group 1 (n = 15) which was subjected to glans penis HA injection and gro...
journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
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更新日期:2019-09-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章
doi:10.1038/sj.ijir.3901335
更新日期:2005-07-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 临床试验,杂志文章
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更新日期:1998-12-01 00:00:00
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journal_title:International journal of impotence research
pub_type: 杂志文章,随机对照试验
doi:10.1038/ijir.2008.22
更新日期:2008-07-01 00:00:00