Immunopathology of psoriasis and psoriatic arthritis.

Abstract:

:Psoriatic arthritis (PsA) is characterised by several unique clinical features that differentiate it from rheumatoid arthritis (RA). Attempts to identify immunopathological mechanisms, some shared with psoriasis, that underlie these differences from RA have been most challenging. Recent research studies, however, highlight novel findings in PsA at the molecular, cellular, and tissue levels that form the basis for a new understanding of this relatively common form of inflammatory arthritis. In particular, the availability of new, biological antitumour necrosis factor alpha therapies have allowed further insight into the immunopathology of psoriasis and PsA. This brief review focuses on immunohistological studies in psoriatic skin, PsA synovium, and bone to demonstrate how these data advance our knowledge of disease pathogenesis.

journal_name

Ann Rheum Dis

authors

Veale DJ,Ritchlin C,FitzGerald O

doi

10.1136/ard.2004.031740

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

ii26-9

eissn

0003-4967

issn

1468-2060

pii

64/suppl_2/ii26

journal_volume

64 Suppl 2

pub_type

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