Abstract:
BACKGROUND:We tested the hypothesis that endurance over-training could alter the favorable effects of well-tolerated training on lipid profile. METHODS:At weeks 1, 6, 15, 26, 36, and 47 of the training program, blood was drawn to test lipid profile of 20 endurance-trained rowers. Diet and caloric intake were controlled. RESULTS:Over-training was diagnosed in five subjects (loss of performance, asthenia, sleep disturbance...) at week 15 and lipid profile of well-trained and over-trained subjects were compared. Training improved cholesterolemic profile and lowered insulin resistance (HOMA-IR: -39 +/- 9%; p=0.02), and triglycerides concentration (-30 +/- 6%; p=0.05) in rowers who did not change to demonstrate over-training. Plasma LPL (+29 +/- 11%; p=0.01) and hepatic lipase (+5 +/- 3%; p=0.01) activities increased in this group suggesting higher TG utilization and turnover. After week 15 and regarding the well-trained condition for the five over-trained subjects, VLDL-TG (-13 +/- 7 %; p=0.03) and Apo-C(3) (-31 +/- 13%; p=0.01) concentrations decreased, while insulin resistance (+17 +/- 7%; p=0.03) and glycerol concentration (+17 +/- 3%; p=0.01) increased and hepatic lipase activity decreased (-14 +/- 4%; p=0.01). CONCLUSION:Over-training was accompanied by alterations in the lipid profile, which appeared to be the consequence of over-training.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Petibois C,Déléris Gdoi
10.1016/j.arcmed.2004.11.013subject
Has Abstractpub_date
2004-11-01 00:00:00pages
532-9issue
6eissn
0188-4409issn
1873-5487pii
S0188-4409(04)00144-4journal_volume
35pub_type
杂志文章abstract:BACKGROUND:A comprehensive understanding of the immune response induced by Mycobacterium bovis Bacille Calmette-Guérin in activation of protective T cells against tuberculosis is important to develop effective therapies to combat this disease. In this study, our experiments were designed to determine effects of transfo...
journal_title:Archives of medical research
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doi:10.1016/s0188-4409(02)00463-0
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abstract::The prevalence of antibodies against the repeat epitope of the circumsporozoite protein (cs) of the standard (PV210) and variant (PVK247) strain of Plasmodium vivax was determined by ELISA in 1170 sera from individual residents of seven localities of the Region Huasteca of San Luis Potosi, Mexico. The capture antigens...
journal_title:Archives of medical research
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abstract::Mongolian gerbils were inoculated intracecally with E. histolytica trophozoites cultured monoxenically. During the first hours of interaction an increase in mucus production was observed. Microulcerative mucosal lesions appeared 24 to 72 h post-inoculation. Inflammatory infiltrate and edema of the lamina propria were ...
journal_title:Archives of medical research
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abstract:BACKGROUND:Although Leishmania virulence may be modulated by environmental and genetic factors of their mammalian hosts and sand fly vectors, molecular determinants of Leishmania sp. are the key elements. This work evidences that Leishmania amazonensis axenic amastigotes produce comparatively more NO than infective pro...
journal_title:Archives of medical research
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doi:10.1016/j.arcmed.2005.07.011
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abstract::Blood-brain barrier (BBB) disruption has been associated with several acute and chronic brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy. This represents a critical situation because damaged integrity of the BBB is related to the influx of immune mediators, plasma proteins and other outsid...
journal_title:Archives of medical research
pub_type: 杂志文章,评审
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abstract:BACKGROUND AND AIMS:Small cell lung cancer (SCLC) is frequently associated with syndrome of inappropriate antidiuretic hormone (SIADH) secretion. In this study we investigated the prognostic value of SIADH in Chinese patients with SCLC. METHODS:We prospectively studied a total of 385 patients with SCLC diagnosed in ou...
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abstract:BACKGROUND AND AIMS:High mobility group box 1 (HMGB1) plays an important role as a pro-inflammatory cytokine that regulates inflammation in various diseases. We hypothesized that hemin might reduce HMGB1 release through the induction of HO-1 in UVB-induced HaCaTs. METHODS:The effects of hemin on the release of HMGB1 i...
journal_title:Archives of medical research
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更新日期:2017-07-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章,评审
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journal_title:Archives of medical research
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doi:10.1016/j.arcmed.2004.10.003
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abstract::Gene therapy holds great promise. Somatic gene therapy has the potential to treat a wide range of disorders, including inherited conditions, cancers, and infectious diseases. Early progress has already been made in the treatment of a range of disorders. Ethical issues surrounding somatic gene therapy are primarily tho...
journal_title:Archives of medical research
pub_type: 杂志文章,评审
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更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:It is well documented that Giardia duodenalis undergoes surface antigenic variation both in vivo and in vitro. Proteins involved have been characterized and referred to as VSP (variable surface protein). METHODS:Two cloned cDNA inserts of 0.45 and 1.95 kb were obtained from G. duodenalis expression library ...
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doi:10.1016/j.arcmed.2003.12.005
更新日期:2004-05-01 00:00:00
abstract::Cholelithiasis is one of the most prevalent gastroenterological diseases, precipitated mainly by environmental factors. However, twin studies provided strong evidence for a role of genetic factors in the disease pathogenesis. An association between plasma lipoprotein levels and gallstone disease (GSD) was presented. A...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2006.11.003
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Phosphodiesterases 5 and 9 (PDE5, PDE9) are enzymes responsible for regulating second messenger signaling by hydrolyzing 3',5' cyclic guanosine monophosphate (cGMP). PDE isoforms are deregulated in some types of human cancer. The present study was carried out to evaluate the expression of phosphodie...
journal_title:Archives of medical research
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doi:10.1016/j.arcmed.2012.08.006
更新日期:2012-08-01 00:00:00
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doi:10.1016/j.arcmed.2010.01.005
更新日期:2010-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0188-4409(00)00251-4
更新日期:2000-11-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章,评审
doi:10.1016/j.arcmed.2003.08.007
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abstract::Nicorandil, the first clinically applied ATP-sensitive K+ channel (K+ATP) opener with nitrate property, has demonstrated cardioprotective effects in patients with multiples of heart diseases. However, it is unknown whether nicorandil has effects on left ventricular (LV) remodeling in rats with ischemic heart failure a...
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journal_title:Archives of medical research
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更新日期:2013-04-01 00:00:00
abstract::High-risk-type human papillomavirus DNA sequences are found in a high percentage of carcinomas from the uterine-cervix, with the viral E1-E2 gene region usually disrupted and the E6 and E7 oncoproteins consistently expressed. The E2 protein is known to repress early transcription from genital HPV promoters having a pr...
journal_title:Archives of medical research
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doi:
更新日期:1996-10-01 00:00:00
abstract::The fundamental principle of stem cell biology is that cells with the potential for both self-renewal and terminal differentiation into one or more cell types may be found in a given tissue. The corollary of this principle is that the stem cells give rise to tissues in which they reside, the so-called expected tissues...
journal_title:Archives of medical research
pub_type: 杂志文章,评审
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journal_title:Archives of medical research
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doi:10.1016/j.arcmed.2004.10.005
更新日期:2005-01-01 00:00:00
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journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2012.08.014
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:TCF, TPF/YY1, and the Sp family are specific transcription factors that bind sequences found within the uteroglobin (UG) gene promoter region that are necessary for transcription. To date, UG gene expression and regulation in vivo are not fully understood. The purpose of this study was to assess the expressi...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/s0188-4409(01)00289-2
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Quinolone-induced mutagenesis in the Salmonella typhimurium hisG48 strains suggests that these antibiotics are oxygen free radical generators. The use of beta-carotene as antioxidant was evaluated as an alternative to reduce oxidative cell damage in patients who need therapy with nalidixic acid, norfloxacin,...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/s0188-4409(00)00046-1
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND AND AIMS:In this study, we aimed to investigate whether 1800 MHz frequency electromagnetic radiation (EMR) has an effect on bone healing. METHODS:A total of 30 Wistar albino rats were divided into two equal groups. Fractures were created in the right tibias of all rats; next, intramedullary fixations with K...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2014.01.006
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:We assessed the auditory function of 94 patients with type 2 diabetes mellitus and 94 age- and sex-matched healthy subjects. METHODS:To study the influence of the clinical characteristics of the disease on the auditory function, after a clinical interview with ophthalmological assessment, subjects were eval...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2005.02.002
更新日期:2005-09-01 00:00:00
abstract::Corneal neovascularization is a significant, sight-threatening complication of many ocular surface disorders. Various growth factors and proteinases are involved in corneal neovascularization. The data supporting a causal role for vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are exten...
journal_title:Archives of medical research
pub_type: 杂志文章,评审
doi:10.1016/j.arcmed.2007.04.006
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Studies in platelet of 5-HT uptake transporters have been performed using binding assay methodology designed for ligand-receptor interactions; however, uptake transporters present requirements that may question the validity of these particular binding assays. METHODS:To explore methodologic aspects that may...
journal_title:Archives of medical research
pub_type: 杂志文章
doi:10.1016/j.arcmed.2003.03.001
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Previously, TP53 codon 72 polymorphisms have been implicated as risk factors for various cancers. Several studies have been conducted on the association of TP53 codon 72 polymorphisms with susceptibility to nasopharyngeal carcinoma (NPC) and have yielded inconclusive results. The aim of the present ...
journal_title:Archives of medical research
pub_type: 杂志文章,meta分析
doi:10.1016/j.arcmed.2009.03.006
更新日期:2009-05-01 00:00:00