Ocular Myasthenia Gravis.

Abstract:

:Myasthenia gravis (MG) is an autoimmune disorder characterized clinically by proximal weakness and bulbar symptoms and pathologically by damage to the post-synaptic membrane at the neuromuscular junction. Ocular myasthenia gravis (ocular MG) is a form of myasthenia gravis whereby the patients' weakness is limited to the muscles of the eyes and eyelids (levator palpebrae superioris). Although not life-threatening, the limitations posed by ocular myasthenia gravis can prove disabling and distressing to patients. Acetylcholinesterase inhibitors such as pyridostigmine or neostigmine are the preferred first-line treatment for ocular myasthenia gravis, with mild cases requiring no additional intervention. However, in moderate or severe cases, treatment must be tailored to the needs and desires of the patient. Intravenous immunoglobulin, although costly, is safe and effective at treating MG. Corticosteroids are effective at reducing or eliminating symptoms and may modify the long-term course of the illness. Steroid-sparing agents such as azathioprine and mycophenolate mofetil are reasonably safe and well-tolerated alternatives to steroids. Surgical interventions such as strabismus surgery and eyelid suspension serve to correct impairments refractory to medical management. Thymectomy, although less frequently recommended, is a reasonable consideration, especially for young adults, given the potential for long-term benefit.

authors

Porter NC,Salter BC

doi

10.1007/s11940-005-0009-z

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

79-88

issue

1

eissn

1092-8480

issn

1534-3138

journal_volume

7

pub_type

杂志文章
  • Cholesterol lowering to prevent stroke: who, when, and how?

    abstract::The epidemiologic link between increased low-density-lipoprotein (LDL) cholesterol and ischemic stroke is controversial. However, recent trials make it clear that LDL reduction by statin agents in high-risk patients reduces the risk of ischemic stroke. The risk of first stroke is reduced within 1 to 2 years of statin ...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-006-0039-1

    authors: Bernstein RA

    更新日期:2006-11-01 00:00:00

  • Treatment of melanoma-associated retinopathy.

    abstract:OPINION STATEMENT:Melanoma-associated retinopathy is a rare paraneoplastic disorder that is challenging to diagnose and even more difficult to treat. Because of the rarity of the disease, therapy is based on analysis of case series and case reports. Based on evidence from these reports, first-line therapy is cytoreduct...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-009-0057-x

    authors: Powell SF,Dudek AZ

    更新日期:2010-01-01 00:00:00

  • Acute and recurrent viral meningitis.

    abstract::Acute viral meningitis is the most common infection of the central nervous system. Most cases occur in children and young adults and are due to enteroviruses. Although the common causes of acute viral meningitis still lack treatment with an effective antiviral agent, management of patients is changing because of bette...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-008-0018-9

    authors: Davis LE

    更新日期:2008-05-01 00:00:00

  • Acute Hearing Loss.

    abstract::Acute hearing loss (AHL) is a medical urgency. The management of patients presenting with sudden deafness involves detecting the causal mechanism and administering emergency therapeutic drugs to restore hearing by minimizing the period of cellular ischemia to the inner ear. Acute management of AHL consists of administ...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-004-0039-y

    authors: Tamhankar M,Solomon D

    更新日期:2004-01-01 00:00:00

  • Herpes zoster ophthalmicus.

    abstract:OPINION STATEMENT:The management of herpes zoster (HZ) usually involves a multidisciplinary approach aiming to reduce complications and morbidity. Patients with herpes zoster ophthalmicus (HZO) are referred to ophthalmologists for prevention or treatment of its potential complications. Without prompt detection and trea...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-010-0098-1

    authors: Sanjay S,Huang P,Lavanya R

    更新日期:2011-02-01 00:00:00

  • Red Blood Cell Transfusion and Transfusion Alternatives in Traumatic Brain Injury.

    abstract::OPINION STATEMENT: Anemia develops in about 50% of patients hospitalized with traumatic brain injury (TBI) and is recognized as a cause of secondary brain injury. This review examines the effects of anemia and transfusion on TBI patients through a literature search to identify original research on anemia and transfusi...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-012-0167-8

    authors: Kramer AH,Le Roux P

    更新日期:2012-04-01 00:00:00

  • Treatment of nonconvulsive status epilepticus.

    abstract:OPINION STATEMENT:Status epilepticus is a neurologic emergency with significant potential morbidity and even mortality. It should be diagnosed and treated as quickly as possible, with concurrent rapid identification of the underlying cause. Nonconvulsive status epilepticus can be difficult to diagnose due to its protea...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-012-0179-4

    authors: Pang T,Drislane FW

    更新日期:2012-08-01 00:00:00

  • Risk Factors for Sudden Unexpected Death in Epilepsy (SUDEP) and Their Mitigation.

    abstract:PURPOSE OF REVIEW:People with epilepsy have an increased risk of mortality when compared to the general population. Sudden unexpected death in epilepsy (SUDEP) is the most common cause of epilepsy-related death in children and adults. The purpose of this review is to discuss SUDEP, with an emphasis on SUDEP risk factor...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s11940-019-0547-4

    authors: Whitney R,Donner EJ

    更新日期:2019-02-13 00:00:00

  • Management of symptoms in amyotrophic lateral sclerosis.

    abstract::The mainstay of treatment of amyotrophic lateral sclerosis (ALS) is management of symptoms. Health care providers involved in the care of ALS patients should be armed with the most current knowledge about symptomatic management of these patients so that an aggressive approach to controlling symptoms can be undertaken ...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-008-0009-x

    authors: Thibodeaux LS,Gutierrez A

    更新日期:2008-03-01 00:00:00

  • Diagnosis and management of functional visual deficits.

    abstract::Patients with functional or nonorganic visual disturbances are often seen in general ophthalmology practice and then referred to neurology and/or neuro-ophthalmology. The diagnosis of functional vision loss requires comprehensive examinations and diagnostic testing to eliminate possible organic entities. Inconsistenci...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-996-0023-9

    authors: Leavitt JA

    更新日期:2006-01-01 00:00:00

  • Trigeminal Neuralgia.

    abstract::The initial treatment for trigeminal neuralgia is medical. Carbamazepine is the drug of choice. If the patient proves to be intolerant of carbamazepine, a number of second-line drugs are available, though data on their relative efficacy are nonexistent. Phenytoin, baclofen, clonazepam, and sodium valproate are all wor...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-996-0009-7

    authors: Perkin GD

    更新日期:1999-11-01 00:00:00

  • Neuromyelitis Optica.

    abstract::Neuromyelitis optica (Devic's syndrome) is an uncommon, idiopathic, demyelinating syndrome of the central nervous system that preferentially affects the optic nerves and spinal cord. It frequently is misdiagnosed as severe multiple sclerosis, but usually is readily distinguished from multiple sclerosis in fully develo...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-005-0010-6

    authors: Wingerchuk DM,Weinshenker BG

    更新日期:2005-05-01 00:00:00

  • Autoimmune neuromuscular disorders in childhood.

    abstract:OPINION STATEMENT:Autoimmune neuromuscular disorders in childhood include Guillain-Barré syndrome and its variants, chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), juvenile myasthenia gravis (JMG), and juvenile dermatomyositis (JDM), along with other disorders rarely seen in childhood. In general, the...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-011-0146-5

    authors: McMillan HJ,Darras BT,Kang PB

    更新日期:2011-12-01 00:00:00

  • Non-Rapid Eye Movement Parasomnias.

    abstract::Non-rapid eye movement parasomnias are unique physical or experiential phenomena that disrupt sleep. Non-rapid eye movement parasomnias are common in children, but they typically outgrow them. Sleep-stage shifts caused by sleep-disordered breathing and associated arousals may be precipitating events for episodes of pa...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-004-0032-5

    authors: Farid M,Kushida CA

    更新日期:2004-07-01 00:00:00

  • Treatment of psychosis and dementia in Parkinson's disease.

    abstract:OPINION STATEMENT:Parkinson's disease (PD) has been increasingly recognized as having a multitude of nonmotor symptoms including psychosis, cognitive impairment and dementia, mood disturbances, fatigue, apathy, and sleep disorders. Psychosis and dementia, in particular, greatly affect quality of life for both patients ...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-013-0281-2

    authors: Goldman JG,Holden S

    更新日期:2014-03-01 00:00:00

  • Infantile spasms: treatment challenges.

    abstract:OPINION STATEMENT:Infantile spasms (IS) represent a major therapeutic challenge, as cessation of spasms and normalization of the electroencephalogram (elimination of hypsarrhythmia) are mandatory to prevent cognitive deterioration in previously healthy infants, or to preserve neurocognitive function among those neurolo...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-012-0181-x

    authors: Watemberg N

    更新日期:2012-08-01 00:00:00

  • Lysosomal Storage Diseases.

    abstract::Lysosomal storage disorders (LSDs), over 40 different diseases, are now considered treatable disorders. Only a few short years ago, Lysosomal storage disorders were seen as interesting neurodegenerative disorders without any potential for treatment. Effective treatment strategies such as bone marrow transplantation (B...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-001-0006-9

    authors: Kaye EM

    更新日期:2001-05-01 00:00:00

  • Epilepsy and sleep.

    abstract::A sleep history should be taken routinely in patients with epilepsy. Treatment of sleep disorders and improvement in sleep hygiene may improve seizure control, daytime cognitive functioning, and quality of life. Patients with recurrent sleepiness interfering with daily activities or an Epworth Sleepiness Scale score m...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-006-0017-7

    authors: Herman ST

    更新日期:2006-07-01 00:00:00

  • Selection of Warfarin or One of the New Oral Antithrombotic Agents for Long-Term Prevention of Stroke among Persons with Atrial Fibrillation.

    abstract:OPINION STATEMENT:Atrial fibrillation (AF) is the most common sustained cardiac rhythm disorder, which can potentially increases the risk of stroke by five-fold, thus, resulting in high public healthcare burden. Stroke prevention is vital in the management of AF patients. Vitamin K antagonists (VKA, eg, warfarin) have ...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-014-0331-4

    authors: Xiong Q,Lip GY

    更新日期:2015-02-01 00:00:00

  • The Therapy of Lyme Neuroborreliosis.

    abstract::The challenge for the neurologist in the treatment of Lyme neuroborreliosis is not in the treatment per se, but in the diagnosis. Neurological manifestations of Lyme disease can present in many forms, and diagnostic techniques which detect the spirochete directly; the culture or polymerase chain reaction of the spiroc...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-005-0026-y

    authors: Pachner AR

    更新日期:2005-03-01 00:00:00

  • Obstructive sleep apnea in children.

    abstract::Despite increasing recognition of childhood obstructive sleep apnea syndrome (OSAS) as a significant public health problem, treatment of the condition remains inconsistent. Some children are screened using polysomnography and treated only when objective respiratory disturbances are identified. Many others receive aden...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-005-0028-9

    authors: Hoban TF

    更新日期:2005-09-01 00:00:00

  • Multiple Sclerosis: Immunotherapy.

    abstract::Given our current knowledge, there is a need for the early institution of immunomodulatory therapy, especially for patients with poor prognostic factors (motor and cerebellar symptoms, frequent disease exacerbations, and a high level of activity on magnetic resonance imaging ). Patients who progress despite immunomodu...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-999-0004-x

    authors: Bielekova B,Martin R

    更新日期:1999-07-01 00:00:00

  • Antiphospholipid Antibody Syndrome.

    abstract::When the diagnosis of antiphospholipid antibody syndrome (aPS) is being considered in persons who have experienced an ischemic stroke or a transient ischemic attack, it is important to gauge how well the history and laboratory data fit with this diagnosis as opposed to other causes of infarct. The fewer the number of ...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-000-0043-9

    authors: Jacobs BS,Levine SR

    更新日期:2000-09-01 00:00:00

  • Essential Tremor.

    abstract::Multiple pharmacologic treatments have been studied, but propranolol and primidone have proven to be the most effective medications. It is unlikely that a patient will respond miraculously to another medication if his or her response to propranolol and primidone is minimal. Some subsets of essential tremor, however, s...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-999-0027-3

    authors: Lambert D,Waters CH

    更新日期:1999-03-01 00:00:00

  • Genotype and Phenotype in Multiple Sclerosis-Potential for Disease Course Prediction?

    abstract:PURPOSE OF REVIEW:This review will examine the current evidence that genetic and/or epigenetic variation may influence the multiple sclerosis (MS) clinical course, phenotype, and measures of MS severity including disability progression and relapse rate. RECENT FINDINGS:There is little evidence that MS clinical phenoty...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s11940-018-0505-6

    authors: Jokubaitis VG,Zhou Y,Butzkueven H,Taylor BV

    更新日期:2018-04-24 00:00:00

  • B-cell targeting agents in the treatment of multiple sclerosis.

    abstract:OPINION STATEMENT:The aims of this article are to discuss the potential role of B lymphocytes in the pathogenesis of multiple sclerosis (MS) and in the mechanisms of action of approved and emerging disease modifying therapies. Over the last few years, significant progress has been made in the introduction of novel phar...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-013-0232-y

    authors: Braley TJ,Segal BM

    更新日期:2013-06-01 00:00:00

  • Treatment of epilepsy in the elderly.

    abstract::The elderly are the most rapidly growing segment of the population, and the incidence of epilepsy in persons over 65 is higher than in any other age group. In nursing homes, its incidence is even higher than in community-dwelling persons of similar ages. About 10% of nursing home residents are being treated with antie...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-008-0026-9

    authors: Leppik IE

    更新日期:2008-07-01 00:00:00

  • Treatment of Sleep Dysfunction in Parkinson's Disease.

    abstract:OPINION STATEMENT:Impaired sleep and alertness affect the majority of Parkinson's disease (PD) patients, negatively impacting safety and quality of life. The etiology of impaired sleep-wake cycle in PD is multifactorial and encompasses medication side effects, nocturnal PD motor symptoms, and presence of co-existent sl...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s11940-017-0461-6

    authors: Amara AW,Chahine LM,Videnovic A

    更新日期:2017-07-01 00:00:00

  • Vision Disturbances Following Traumatic Brain Injury.

    abstract::Vision disturbances following traumatic brain injury (TBI) include anomalies of accommodation, version, vergence (nonstrabismic, as well as strabismic), photosensitivity, visual field integrity, and ocular health. Traumatic brain injury patients with complex diplopia patterns, noncomitant strabismic anomalies, and adv...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-002-0027-z

    authors: Kapoor N,Ciuffreda KJ

    更新日期:2002-07-01 00:00:00

  • Progressive Myoclonic Epilepsies.

    abstract::The treatment of progressive myoclonus epilepsy (PME) remains a major therapeutic challenge in neurology. Generalized convulsive seizures are often well controlled through classic antiepileptic drugs (AEDs) like valproate and clonazepam, whereas myoclonus, the main symptom that is affecting patients most in their dail...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-002-0001-9

    authors: Uthman BM,Reichl A

    更新日期:2002-01-01 00:00:00