Abstract：
:When the diagnosis of antiphospholipid antibody syndrome (aPS) is being considered in persons who have experienced an ischemic stroke or a transient ischemic attack, it is important to gauge how well the history and laboratory data fit with this diagnosis as opposed to other causes of infarct. The fewer the number of typical vascular disease risk factors and the more confirmatory the laboratory findings (ie, high anticardiolipin antibody titers or presence of lupus anticoagulant), the stronger the suspicion of aPS. There are no good prospective randomized data on stroke prevention with any form of therapy following a first stroke or transient ischemic attack associated with antiphospholipid antibody (aPL). Short-term anticoagulation with an International Normalized Ratio (INR) of 2.0 to 3.0 may be considered in these cases, as could antiplatelet agents if no clear cardiac source is found. If anticoagulation is chosen, if there is no recurrence, and if the level of aPL appears to decline, a change to a stroke prevention medication that may carry less risk, such as an antiplatelet agent, may be appropriate. In patients with more typical vascular disease risk factors and less confirmatory laboratory evidence of aPS (ie, low to moderate titer of anticardiolipin antibodies and lack of other clinical or serologic evidence of aPS), a more conservative approach may be considered and antiplatelet therapy initiated. In either situation, close follow-up for recurrent thrombosis and aPL can help determine whether more or less aggressive (risky) therapies should be considered. Results of randomized controlled trials of different treatment options for aPS are awaited.
journal_name
Curr Treat Options Neuroljournal_title
Current treatment options in neurologyauthors
Jacobs BS,Levine SRdoi
10.1007/s11940-000-0043-9subject
Has Abstractpub_date
2000-09-01 00:00:00pages
449-458issue
5eissn
1092-8480issn
1534-3138journal_volume
2pub_type
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journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-001-0048-z
更新日期：2001-03-01 00:00:00
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journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-018-0536-z
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journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
pub_type： 杂志文章
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journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
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journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
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doi：10.1007/s11940-007-0031-4
更新日期：2007-01-01 00:00:00
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journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-014-0331-4
更新日期：2015-02-01 00:00:00
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journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-019-0586-x
更新日期：2019-09-27 00:00:00
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journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-016-0434-1
更新日期：2016-12-01 00:00:00
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journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-996-0011-0
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journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
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更新日期：2017-09-21 00:00:00
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journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
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更新日期：2012-12-01 00:00:00
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journal_title：Current treatment options in neurology
pub_type： 杂志文章
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journal_title：Current treatment options in neurology
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更新日期：2003-05-01 00:00:00
abstract：OPINION STATEMENT:Paraneoplastic brain stem encephalitis can occur as an isolated clinical syndrome or, more often, may be part of a more widespread encephalitis. Different antineuronal autoantibodies, such as anti-Hu, anti-Ri, and anti-Ma2 can be associated with the syndrome, and the most frequent tumors are lung and ...
journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
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abstract：:Lysosomal storage disorders (LSDs), over 40 different diseases, are now considered treatable disorders. Only a few short years ago, Lysosomal storage disorders were seen as interesting neurodegenerative disorders without any potential for treatment. Effective treatment strategies such as bone marrow transplantation (B...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-001-0006-9
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journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-999-0023-7
更新日期：1999-09-01 00:00:00
abstract：OPINION STATEMENT:Kleine-Levin Syndrome [KLS] is often under-recognized and also misdiagnosed. When suspicion for KLS is raised, a thorough clinical evaluation should be performed, including detailed history from family members and a neurologic and psychiatric examination. Additional studies may include PSG, EEG, neuro...
journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-016-0409-2
更新日期：2016-06-01 00:00:00
