Paraneoplastic brain stem encephalitis.

Abstract:

OPINION STATEMENT:Paraneoplastic brain stem encephalitis can occur as an isolated clinical syndrome or, more often, may be part of a more widespread encephalitis. Different antineuronal autoantibodies, such as anti-Hu, anti-Ri, and anti-Ma2 can be associated with the syndrome, and the most frequent tumors are lung and testicular cancer. Anti-Hu-associated brain stem encephalitis does not normally respond to immunotherapy; the syndrome may stabilize under tumor treatment. Brain stem encephalitis with anti-Ma2 often improves after immunotherapy and/or tumor therapy, whereas only a minority of anti-Ri positive patients respond to immunosuppressants or tumor treatment. The Opsoclonus-myoclonus syndrome (OMS) in children, almost exclusively associated with neuroblastoma, shows a good response to steroids, ACTH, and rituximab, some patients do respond to intravenous immunoglobulins or cyclophosphamide. In adults, OMS is mainly associated with small cell lung cancer or gynecological tumors and only a small part of the patients show improvement after immunotherapy. Earlier diagnosis and treatment seem to be one major problem to improve the prognosis of both, paraneoplastic brain stem encephalitis, and OMS.

authors

Blaes F

doi

10.1007/s11940-013-0221-1

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

201-9

issue

2

eissn

1092-8480

issn

1534-3138

journal_volume

15

pub_type

杂志文章
  • Treatment of neurofibromatosis type 1.

    abstract:OPINION STATEMENT:Neurofibromatosis type 1 (NF1) is a genetic multisystemic disorder involving the skin, the central and peripheral nervous systems, bones, and the cardiovascular and endocrine systems. This condition is caused by inherited or de novo mutations of the NF1 gene at the 17q11.2 chromosomal region, a gene t...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-015-0355-4

    authors: Sabatini C,Milani D,Menni F,Tadini G,Esposito S

    更新日期:2015-06-01 00:00:00

  • Modern treatment options for intracerebral hemorrhage.

    abstract::Spontaneous intracerebral hemorrhage (ICH) is a devastating neurological event with a 30-day mortality of approximately 40%. Recent research provides new insights into the pathophysiology of ICH-associated edema, with potential molecular and cellular targets for future therapy. Neuroimaging techniques such as gradient...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-006-0005-y

    authors: Freeman WD,Brott TG

    更新日期:2006-03-01 00:00:00

  • Effects of Treatment on Endocrine Function in Patients with Epilepsy.

    abstract::Antiepileptic drug (AED) treatment is associated with multiple short- and long-term side effects. Effects on endocrine function, including weight change, reproductive function, thyroid function, and bone health are examples of these side effects. Some AEDs affect weight, resulting in weight gain or loss. Levetiracetam...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-005-0037-8

    authors: Pack A

    更新日期:2005-07-01 00:00:00

  • Overview of therapeutic hypothermia.

    abstract:OPINION STATEMENT:Therapeutic hypothermia has proven neuroprotective effects in global cerebral ischemia. Indications for hypothermia induction include cardiac arrest and neonatal asphyxia. The two general methods of induced hypothermia are either surface cooling or endovascular cooling. Hypothermia should be induced a...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-012-0201-x

    authors: Song SS,Lyden PD

    更新日期:2012-12-01 00:00:00

  • Hemifacial Spasm.

    abstract::Hemifacial spasm (HFS) is a peripheral movement disorder caused by direct or indirect compression or distortion of the root exit zone of the seventh cranial nerve, which is most commonly compressed by an arterial loop, but also may be compressed by a tumor, cyst, or aneurysm. All patients with HFS should undergo magne...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-004-0009-4

    authors: Kemp LW,Reich SG

    更新日期:2004-05-01 00:00:00

  • Infantile spasms: treatment challenges.

    abstract:OPINION STATEMENT:Infantile spasms (IS) represent a major therapeutic challenge, as cessation of spasms and normalization of the electroencephalogram (elimination of hypsarrhythmia) are mandatory to prevent cognitive deterioration in previously healthy infants, or to preserve neurocognitive function among those neurolo...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-012-0181-x

    authors: Watemberg N

    更新日期:2012-08-01 00:00:00

  • Essential Tremor.

    abstract::Multiple pharmacologic treatments have been studied, but propranolol and primidone have proven to be the most effective medications. It is unlikely that a patient will respond miraculously to another medication if his or her response to propranolol and primidone is minimal. Some subsets of essential tremor, however, s...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-999-0027-3

    authors: Lambert D,Waters CH

    更新日期:1999-03-01 00:00:00

  • Myoclonus: Pathophysiology and Treatment Options.

    abstract:OPINION STATEMENT:Treatment of myoclonus requires an understanding of the physiopathology of the condition. The first step in treatment is to determine if there is an epileptic component to the myoclonus and treat accordingly. Secondly, a review of medications (e.g., opiates) and comorbidities (e.g., hepatic or renal f...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s11940-016-0404-7

    authors: Levy A,Chen R

    更新日期:2016-05-01 00:00:00

  • Transcranial direct current stimulation for major depression: a general system for quantifying transcranial electrotherapy dosage.

    abstract::There has been a recent resurgence of interest in therapeutic modalities using transcranial weak electrical stimulation through scalp electrodes, such as trans-cranial direct current stimulation (tDCS), as a means of experimentally modifying and studying brain function and possibly treating psychiatric conditions. A r...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-008-0040-y

    authors: Bikson M,Bulow P,Stiller JW,Datta A,Battaglia F,Karnup SV,Postolache TT

    更新日期:2008-09-01 00:00:00

  • Acute Disseminated Encephalomyelitis.

    abstract::There is no standard therapy for acute disseminated encephalomyelitis (ADEM), and treatments are based on the analogy of the pathogenesis of ADEM with that of multiple sclerosis (MS), namely an inflammatory perivenular demyelination. High-dose intravenous corticosteroids, such as methylprednisolone, at a dosage standa...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-001-0016-7

    authors: Tselis A

    更新日期:2001-11-01 00:00:00

  • Subarachnoid Hemorrhage.

    abstract::All patients who present with subarachnoid hemorrhage should be admitted to the intensive care unit for close neurologic and cardiorespiratory monitoring. Neurosurgical consultation should be obtained if external ventricular drain placement, arteriography, or surgical planning are considered. Seizure prophylaxis, anti...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-999-0010-z

    authors: Flemming KD,Brown RD Jr,Wiebers DO

    更新日期:1999-05-01 00:00:00

  • Botulinum toxin in the management of dystonia.

    abstract::Dystonia is a neurologic disorder that can occur at any age and often results in significant disability. The therapeutic application of botulinum toxin has revolutionized the treatment of this disorder, particularly for the adult-onset focal forms such as cervical dystonia and blepharospasm. The two available commerci...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/BF02938412

    authors: Cardona-Garcia OD,Higgins DS,Molho ES

    更新日期:2007-05-01 00:00:00

  • Treatment options for tauopathies.

    abstract:OPINION STATEMENT:To date, there are no approved and established pharmacologic treatment options for tauopathies, a very heterogenous group of neuropsychiatric diseases often leading to dementia and clinically diagnosed as atypical Parkinson syndromes. Among these so-called Parkinson plus syndromes are progressive supr...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-012-0168-7

    authors: Karakaya T,Fußer F,Prvulovic D,Hampel H

    更新日期:2012-04-01 00:00:00

  • Newly diagnosed high-grade gliomas.

    abstract:OPINION STATEMENT:High-grade or malignant gliomas are aggressive cancers. The World Health Organization (WHO) grading system recognizes grade III and grade IV primary brain tumors of astrocytic, oligodendroglial, or mixed lineage. Identification of these tumors is prompted by symptoms such as insidious headaches, seizu...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-010-0077-6

    authors: Giglio P,Villano JL

    更新日期:2010-07-01 00:00:00

  • Arteriovenous Malformations in the Brain.

    abstract::Arteriovenous malformations (AVM) are a leading cause of intracerebral hemorrhage, especially among the young. Because they pose a lifelong risk of serious bleeding, definitive treatment to obliterate the AVM should be pursued in the majority of patients. Microsurgical resection of a small AVM located in the superfici...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-002-0011-7

    authors: Graham GD

    更新日期:2002-11-01 00:00:00

  • DBS in Dystonia and Other Hyperkinetic Movement Disorders.

    abstract:OPINION STATEMENT:The diagnosis and appropriate treatment of hyperkinetic movement disorders require a work up of potentially reversible metabolic, infectious and structural disorders as well as side effects of current medication. In pharmacoresistant movement disorders with a disabling impact on quality of life, deep ...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-015-0373-2

    authors: Barbey A,Bloch J,Vingerhoets FJ

    更新日期:2015-09-01 00:00:00

  • Orthostatic Hypotension in Multiple System Atrophy.

    abstract::There is no known way to cure multiple system atrophy or even to slow its insidious progression, but there are opportunities to treat many of its symptoms and complications. Of all the autonomic disturbances it causes, orthostatic hypotension is associated with one of the better chances for successful intervention. Mi...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-000-0005-2

    authors: Riley DE

    更新日期:2000-05-01 00:00:00

  • Branched-chain Ketoacyl Dehydrogenase Deficiency: Maple Syrup Disease.

    abstract::Classic maple syrup disease can be managed to allow a benign neonatal course, normal growth, and low hospitalization rates. The majority of affected infants that are prospectively managed have good neurodevelopmental outcome; however, acute metabolic intoxication and neurologic deterioration can develop rapidly at any...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-003-0039-3

    authors: Strauss KA,Morton DH

    更新日期:2003-07-01 00:00:00

  • Secondary Causes of Myositis.

    abstract:Purpose of review:The purpose of this paper is to comprehensively evaluate secondary causes of inflammatory myopathies (myositis) and to review treatment options. Recent findings:This review highlights recent advancements in our understanding of known causes of myositis, including newer drugs that may cause myositis s...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s11940-020-00646-0

    authors: Berth SH,Lloyd TE

    更新日期:2020-01-01 00:00:00

  • Central nervous system vasculitis.

    abstract:OPINION STATEMENT:A patient presenting with suspected primary central nervous system (CNS) vasculitis is often difficult to manage. Once the diagnosis is suspected, the clinical course may already be severe and warrant timely aggressive treatment with potentially toxic drugs. Definitive diagnosis is often delayed, requ...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-013-0227-8

    authors: Gotkine M,Vaknin-Dembinsky A

    更新日期:2013-06-01 00:00:00

  • Cysticercosis.

    abstract::Cysticercosis, the consequence of ingesting viable eggs of the porcine tapeworm Taenia solium, currently remains one of the most common human parasitic conditions worldwide. Although preventable by the proper disposal of human wastes, cysticercosis of the central nervous system (neurocysticercosis) accounts for a subs...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-000-0052-8

    authors: Bale JF Jr

    更新日期:2000-07-01 00:00:00

  • Myotonic Dystrophy Type 1 Management and Therapeutics.

    abstract:OPINION STATEMENT:Myotonic dystrophy (DM1) is the most common form of adult muscular dystrophy. It is a multisystem disorder with a complex pathophysiology. Although inheritance is autosomal dominant, disease variability is attributed to anticipation, a maternal expansion bias, variable penetrance, somatic mosaicism, a...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s11940-016-0434-1

    authors: Smith CA,Gutmann L

    更新日期:2016-12-01 00:00:00

  • Management of hyponatremia in various clinical situations.

    abstract:OPINION STATEMENT:Hyponatremia is the most common electrolyte abnormality in both inpatient and outpatient settings. The condition primarily results from the combination of impaired free water excretion due to elevated vasopressin levels in conjunction with a source of free water intake. Recent studies have revealed th...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-014-0310-9

    authors: Moritz ML,Ayus JC

    更新日期:2014-09-01 00:00:00

  • Cerebral Palsy.

    abstract::The neurorehabilitation program for cerebral palsy changes over time. During the first 2 years of life, an infant stimulation program with an emphasis on more than just improving motor deficits is emphasized. The importance of involvement of a knowledgeable therapist cannot be overemphasized. Realistic expectations mu...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-000-0011-4

    authors: Russman BS

    更新日期:2000-03-01 00:00:00

  • Treatment of nonconvulsive status epilepticus.

    abstract:OPINION STATEMENT:Status epilepticus is a neurologic emergency with significant potential morbidity and even mortality. It should be diagnosed and treated as quickly as possible, with concurrent rapid identification of the underlying cause. Nonconvulsive status epilepticus can be difficult to diagnose due to its protea...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-012-0179-4

    authors: Pang T,Drislane FW

    更新日期:2012-08-01 00:00:00

  • Treatment of epilepsy in the elderly.

    abstract::The elderly are the most rapidly growing segment of the population, and the incidence of epilepsy in persons over 65 is higher than in any other age group. In nursing homes, its incidence is even higher than in community-dwelling persons of similar ages. About 10% of nursing home residents are being treated with antie...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-008-0026-9

    authors: Leppik IE

    更新日期:2008-07-01 00:00:00

  • Epilepsy and sleep.

    abstract::A sleep history should be taken routinely in patients with epilepsy. Treatment of sleep disorders and improvement in sleep hygiene may improve seizure control, daytime cognitive functioning, and quality of life. Patients with recurrent sleepiness interfering with daily activities or an Epworth Sleepiness Scale score m...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-006-0017-7

    authors: Herman ST

    更新日期:2006-07-01 00:00:00

  • Usefulness of PET Imaging to Guide Treatment Options in Gliomas.

    abstract:OPINION STATEMENT:Magnetic resonance imaging (MRI) is the gold standard guiding diagnostic and therapeutic management in glioma with its high resolution and possibility to depict blood-brain-barrier disruption when contrast medium is applied. In light of the shifting paradigms revealing distinct tumor subtypes based on...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-015-0384-z

    authors: Suchorska B,Albert NL,Tonn JC

    更新日期:2016-01-01 00:00:00

  • Cholesterol lowering to prevent stroke: who, when, and how?

    abstract::The epidemiologic link between increased low-density-lipoprotein (LDL) cholesterol and ischemic stroke is controversial. However, recent trials make it clear that LDL reduction by statin agents in high-risk patients reduces the risk of ischemic stroke. The risk of first stroke is reduced within 1 to 2 years of statin ...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-006-0039-1

    authors: Bernstein RA

    更新日期:2006-11-01 00:00:00

  • Update on therapy for narcolepsy.

    abstract:OPINION STATEMENT:Narcolepsy is a severe, incurable, neurological disorder that is treated by pharmacological management of its symptoms. The main symptoms are excessive daytime sleepiness (EDS) and cataplexy, although addition symptoms that may require treatment include sleep paralysis, hypnagogic hallucinations, and ...

    journal_title:Current treatment options in neurology

    pub_type: 杂志文章

    doi:10.1007/s11940-015-0347-4

    authors: Thorpy MJ

    更新日期:2015-05-01 00:00:00