Abstract:
OBJECTIVE:To determine whether an intravitreal injection of triamcinolone acetonide for persistent diabetic macular edema after adequate laser treatment improves visual acuity. DESIGN:Prospective, double-masked, placebo-controlled, randomized clinical trial. PARTICIPANTS AND CONTROLS:Sixty-nine eyes of 43 patients were entered into the study, with 34 eyes randomized to receive active treatment and 35 randomized to receive a placebo injection. Sixty-five of 69 eyes (94%) completed the 3-month study visit. INTERVENTION:Using a 27-gauge needle, 0.1 ml of triamcinolone acetonide was injected through the pars plana. The procedure was performed in a minor procedures area in the outpatient clinic under sterile conditions and using topical and subconjunctival anesthesia. Eyes randomized to placebo received a subconjunctival saline injection using the identical procedure for preparation. MAIN OUTCOME MEASURES:The main outcome measures were improvement of best-corrected logarithm of the minimum angle of resolution visual acuity by 5 or more letters and incidence of moderate or severe adverse events. RESULTS:Eighteen of 33 eyes (55%) treated with triamcinolone gained 5 or more letters of best-corrected visual acuity compared with 5 of 32 eyes (16%) treated with placebo (P = 0.002). Macular edema was reduced by 1 or more grades as determined by masked semiquantitative contact lens examination in 25 of 33 treated eyes (75%) versus 5 of 32 untreated eyes (16%; P<0.0001). Optical coherence tomography showed a mean reduction of central retinal thickness of 152 mum in the 21 treated eyes that were examined compared with a reduction of 36 mum in 20 placebo-treated eyes. Infectious endophthalmitis developed in 1 triamcinolone-treated eye that was treated adequately without loss of visual acuity. CONCLUSIONS:In the short term, intravitreal triamcinolone is an effective and relatively safe treatment for eyes with diabetic macular edema that have failed laser treatment. Although it will be essential to study longer-term outcomes, the use of intravitreal triamcinolone may be considered in 1 eye of patients who continue to lose vision from diabetic macular edema despite conventional management.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Sutter FK,Simpson JM,Gillies MCdoi
10.1016/j.ophtha.2004.05.025subject
Has Abstractpub_date
2004-11-01 00:00:00pages
2044-9issue
11eissn
0161-6420issn
1549-4713pii
S0161-6420(04)00924-8journal_volume
111pub_type
临床试验,杂志文章,随机对照试验相关文献
OPHTHALMOLOGY文献大全abstract:PURPOSE:The purpose of the study was to determine long-term results of involutional entropion repair by a modified corncrib (inverted T) procedure with a Quickert suture. METHODS:A retrospective review of consecutive patients with involutional entropion who underwent repair by a modified corncrib procedure from Januar...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30284-x
更新日期:1997-03-01 00:00:00
abstract:PURPOSE:To investigate the independent impact of the incidence and progression of diabetic retinopathy (DR) on visual functioning (VF). DESIGN:Population-based cohort study. PARTICIPANTS:A total of 518 participants aged 40 to 80 years (baseline visit 2007-2009 and second visit 6 years later, 2013-2015), with diabetes...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2018.02.011
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:The Specular Microscopy Ancillary Study was designed to examine donor corneal endothelial specular image quality, compare the central endothelial cell density determined by eye banks with the endothelial cell density determined by a central specular microscopy reading center, and evaluate donor factors that may...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2004.10.045
更新日期:2005-03-01 00:00:00
abstract::Measurements were made on fundus photographs of the diameters of retinal arterioles in a series of cases with various nonvascular lesions of the anterior visual pathways, before and after the development of fundus signs of optic atrophy. A simple method was devised for reliable estimation of the diameter of the centra...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34144-6
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Transconjunctival cryopexy of the vitreous base is clinically effective in patients with steroid nonresponsive pars planitis who have peripheral neovascularization. Cryoablation of the region previously has been thought to eliminate the areas of permeable neovascular tissue, thus removing the focus of exudat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(13)31726-6
更新日期:1994-07-01 00:00:00
abstract::Ten patients with prolactin-secreting pituitary adenomas (prolactinoma) and visual dysfunction were treated primarily with bromocriptine. Nine patients had improvement of visual field or acuity associated with computed tomography (CT) evidence of a decrease in tumor size and reduction of serum prolactin level (SPL). V...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)33853-8
更新日期:1985-10-01 00:00:00
abstract::Progression of the maculopathy in North Carolina macular dystrophy (NCMD) was not well documented. Thus, the author recently examined 22 affected members of the original kindred. Evidence of progression of the macular disease was sought through comparison of the recent fundus findings with old fundus photographs and f...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32655-8
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:Sterile corneal ulceration is a rare complication of rheumatoid arthritis and may lead to corneal perforation. Surgical management for visual restoration frequently is unsuccessful. The authors analyze the factors that may determine the failure of corneal surgery in perforations associated with rheumatoid ar...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30867-6
更新日期:1995-09-01 00:00:00
abstract:PURPOSE:To compare monthly dosing with a treat and extend algorithm using ranibizumab 0.3 mg with and without angiography-guided macular laser photocoagulation for center-involving diabetic macular edema (DME). DESIGN:Multicenter, prospective, randomized clinical trial. PARTICIPANTS:A total of 150 eyes from 116 subje...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2016.09.021
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:We conducted a meta-analysis of randomized trials of ranibizumab for age-related macular degeneration (AMD) to elucidate systemic vascular risk. CLINICAL RELEVANCE:Although intravitreal vascular endothelial growth factor inhibitors are widely used to treat AMD, whether they produce systemic adverse effects ...
journal_title:Ophthalmology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ophtha.2014.05.022
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:To investigate the association between the vascular endothelial growth factor (VEGF) gene polymorphism and the response to anti-VEGF treatment for choroidal neovascularization (CNV) in highly myopic eyes. DESIGN:Retrospective cohort study. PARTICIPANTS:A total of 357 unrelated highly myopic Japanese patients ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.06.043
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To analyze the success rate of pulsed intravenous (IV) cyclophosphamide (CyP) for noninfectious ocular inflammatory disease and to identify risk factors for failure of therapy. DESIGN:Retrospective, interventional, noncomparative cohort study. PARTICIPANTS:One hundred ten eyes of 65 patients. METHODS:Through...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.01.031
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the incidence and extent of visual recovery in patients with giant cell arteritis (GCA) treated with high doses of systemic corticosteroids. DESIGN:Multicenter prospective case series. PARTICIPANTS:Thirty-four consecutive patients with biopsy-proven GCA and visual loss seen at either Wills Eye H...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2005.01.036
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:To assess the effectiveness of intravitreal aflibercept in patients with neovascular age-related macular degeneration (AMD) previously resistant to treatment with other anti-vascular endothelial growth factor agents. DESIGN:Prospective, open-label, noncontrolled, registered clinical trial. PARTICIPANTS:Fort...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ophtha.2013.08.035
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To determine the most appropriate method for measuring the effect on contrast sensitivity of neodymium:YAG (Nd:YAG) posterior capsulotomy for early posterior capsular opacification (PCO). DESIGN:Prospective comparison of five different methods for luminous contrast sensitivity testing in patients undergoing ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(99)90154-9
更新日期:1999-04-01 00:00:00
abstract:PURPOSE:The differentiating characteristics in blebitis and early and late endophthalmitis after glaucoma filtration surgery are reviewed. METHODS:All admission records and operative reports, as well as available office notes, on patients with blebitis or bleb-associated endophthalmitis admitted to a large referral ey...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30196-1
更新日期:1997-06-01 00:00:00
abstract:PURPOSE:To study the risk factors, clinical features, and treatment of recurrent fungal keratitis after corneal transplantation. DESIGN:Retrospective, interventional case series. PARTICIPANTS:Eight hundred ninety-nine patients (eyes) with fungal keratitis who underwent corneal transplantation at the Shandong Eye Inst...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.10.004
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To determine the cost-effectiveness of cataract surgery worldwide and to compare it with the cost-effectiveness of comparable medical interventions. DESIGN:Meta-analysis. PARTICIPANTS:Approximately 12,000 eyes in the studies selected. METHODS:Articles were identified by searching the literature using the p...
journal_title:Ophthalmology
pub_type: 杂志文章,meta分析
doi:10.1016/j.ophtha.2006.12.013
更新日期:2007-09-01 00:00:00
abstract::Malignant rhabdoid tumor (MRT), originally described as a sarcomatous variant of Wilms' tumor, is now recognized as a distinct, highly malignant entity. The authors describe, for the first time, a primary tumor of the orbit with histologic, immunohistochemical, and ultrastructural features of MRT. Their findings sugge...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32666-2
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate the age-related changes in the position of zonular insertion onto the anterior lens capsule. DESIGN:The study design was an experimental cadaveric eye study. PARTICIPANTS:Two hundred twenty-three cadaveric eyes (range, 16-100 years old) from eye banks in the United States wer...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(98)93172-4
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the ability of stereoscopic nonmydriatic digital retinal imaging to detect ocular pathologic features other than diabetic retinopathy (DR) in patients with diabetes mellitus (DM) compared with dilated retinal examination by retinal specialist ophthalmologists. DESIGN:Clinic-based comparative inst...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2005.12.025
更新日期:2006-05-01 00:00:00
abstract:PURPOSE:To describe the authors' 5-year experience of the 2-incision push-pull (TIPP) technique for pediatric anterior and posterior capsulorrhexis formation. DESIGN:Retrospective descriptive study over a 5-year period. PARTICIPANTS:A total of 84 eyes of 63 patients who had undergone cataract surgery in 1 center. ME...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.03.057
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:To determine whether lamina cribrosa (LC) depth (LCD) and LC thickness (LCT) are associated with a faster rate of progressive retinal nerve fiber layer (RNFL) thinning in primary open-angle glaucoma (POAG). DESIGN:Prospective, observational study. PARTICIPANTS:One hundred ten eyes diagnosed with POAG (n = 1...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2014.10.007
更新日期:2015-04-01 00:00:00
abstract::Sixty-four consecutive patients with aphakic penetrating keratoplasty and penetrating keratoplasty combined with intracapsular cataract extraction were reviewed in a prospective fashion with a minimum of a one-year follow-up. Five were lost to follow-up. There were seven graft failures at the end of one year. Five of ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35187-7
更新日期:1980-07-01 00:00:00
abstract:PURPOSE:To report the usefulness of the Boston type I keratoprosthesis (Massachusetts Eye and Ear Infirmary, Boston, MA) in the management of corneal opacification, corneal limbal stem cell failure, or both in a large single-surgeon series. DESIGN:Retrospective review of consecutive clinical case series. PARTICIPANTS...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.12.058
更新日期:2009-04-01 00:00:00
abstract::The thyroid hormones Thyroxine (T4) and Triiodothyronine (T3) can be measured directly in serum by radioimmunoassay. Most serum T4 and T3 circulates bound to specific serum-binding proteins but the small unbound fraction, free T4, correlates best with hormonal activity. The free T4 concentration can be measured direct...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)35000-3
更新日期:1981-06-01 00:00:00
abstract::The slow-releasing artificial tear (SR-AT) is a soluble polymer in solid form. Placed in the inferior cul-de-sac and allowed to dissolve, it is used to treat dry-eye patients. The SR-AT was studied in two phases. The short-term cross-over study of 40 patients was completed in October 1976. The long-term open study is ...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(78)35610-4
更新日期:1978-08-01 00:00:00
abstract:PURPOSE:To report the therapeutic effects of ethanol (ETOH) irrigation into epithelial iris cysts (EIC). STUDY DESIGN:Retrospective noncomparative interventional case series. PARTICIPANTS:102 eyes of 102 patients aged between 4 and 71 years with EIC, with 4 months to 15 years follow-up. INTERVENTION:Under local or g...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(03)00543-8
更新日期:2003-08-01 00:00:00
abstract:PURPOSE:To identity anatomic risk factors involved in the onset of retinal complications causing decrease of visual acuity (VA) in the fellow eyes of highly myopic patients operated for retinal detachment with macular hole (RDMH). DESIGN:Cohort study. PARTICIPANTS:Ninety-eight patients (mean age, 51.5+/-8.0 years) wi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.02.016
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:To evaluate the effect of glaucoma on functional vision and on vision-related (VR) and health-related (HR) quality of life (QoL) in children up to 16 years of age. DESIGN:Cross-sectional observational study. PARTICIPANTS:One hundred nineteen children 2 to 16 years of age (mean age, 9.4 years; standard deviati...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2017.02.024
更新日期:2017-07-01 00:00:00