Abstract:
PURPOSE:To study the risk factors, clinical features, and treatment of recurrent fungal keratitis after corneal transplantation. DESIGN:Retrospective, interventional case series. PARTICIPANTS:Eight hundred ninety-nine patients (eyes) with fungal keratitis who underwent corneal transplantation at the Shandong Eye Institute between January 2000 and October 2008. Six hundred fourteen patients underwent penetrating keratoplasty (PK) and 285 patients underwent lamellar keratoplasty (LK). METHODS:All patients failed to respond to topical and systemic antifungal drugs treatment before corneal transplantation. A trephine that was 0.5 mm larger in diameter than the infection area was used during PK or LK. Medical records of each patient were reviewed retrospectively. The species of pathogenetic fungi causing recurrence were analyzed. The clinical features, including recurrence time, position, symptom, and physical signs, were summarized. Based on clinical features, appropriate topical and systemic antifungal treatment was determined for all patients; some patients also received combined subconjunctival or intracameral injection of fluconazole. If there was treatment failure, a conjunctival flap or keratoplasty was performed. MAIN OUTCOME MEASURES:Species of pathogenetic fungi, clinical features, and apparent therapeutic effects. RESULTS:Fifty-seven patients (6.34%) experienced recurrence after corneal transplantation. There was no difference between PK (6.79%) and LK (5.96%) in recurrence rate (P = 0.883). A higher rate of recurrences was found in those with preoperative hypopyon (10.90%), corneal perforation (12.00%), corneal infection expanding to limbus (20.69%), or lens infection with extracapsular cataract extraction (50%; P<0.05). The 3 main kinds of recurrence were: (1) recurrent infection from recipient bed to graft, and once recurrent infection invaded the graft, the inflammation progressed more rapidly; (2) white mushroom-shaped hypopyon with anterior chamber recurrence; (3) infection in the posterior chamber and vitreous opacity on posterior segment recurrence. Location of recurrence was: recipient bed (70.18%), anterior chamber (7.02%), and posterior segment (22.81%). The overall cure rate was 82.46%, which included drug therapy (28.07%) and surgical treatment (54.39%). CONCLUSIONS:Hypopyon, corneal perforation, corneal infection expanding to limbus and lens infection are major risk factors for recurrence of fungal keratitis after corneal transplantation. Based on the clinical features of recurrence, appropriate treatment options can help to control the recurrent infection.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Shi W,Wang T,Xie L,Li S,Gao H,Liu J,Li Hdoi
10.1016/j.ophtha.2009.10.004subject
Has Abstractpub_date
2010-05-01 00:00:00pages
890-6issue
5eissn
0161-6420issn
1549-4713pii
S0161-6420(09)01175-0journal_volume
117pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract::Proton irradiation was used in the treatment of uveal melanomas in 36 eyes. The average follow-up period was 16 months. One patient developed metastatic disease and died. No eye has been enucleated and tumor regression has been observed in all 22 eyes with a follow-up of more than 12 months. This type of treatment off...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35212-3
更新日期:1980-06-01 00:00:00
abstract:PURPOSE:To assess the ability of the new pattern electroretinogram optimized for glaucoma detection (PERGLA) paradigm to discriminate between healthy individuals and individuals with glaucomatous optic neuropathy (GON). DESIGN:Cross-sectional study. PARTICIPANTS:One hundred forty-two eyes of 71 participants (42 healt...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.10.026
更新日期:2009-03-01 00:00:00
abstract::The authors reviewed the records of 302 eyes of 185 patients with diffuse diabetic macular edema with or without cystoid macular edema treated with modified grid laser photocoagulation between the years 1981 and 1990. Three years after initial grid treatment, visual acuity was improved in 14.5%, unchanged in 60.9%, an...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(91)32082-7
更新日期:1991-10-01 00:00:00
abstract::A 38-year-old male homosexual with the new Acquired Immunodeficiency Syndrome (AIDS) had biopsy proven Kaposi's sarcoma of the right palpebral conjunctiva, extraocular mucocutaneous areas, and lymph nodes. Histologically, the palpebral tumor was characterized by atypical spindle cell proliferation and multiple slit-li...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(83)80011-6
更新日期:1983-08-01 00:00:00
abstract:PURPOSE:Several retrospective studies have demonstrated the safety and efficacy of sub-Tenon's anesthesia in ocular surgery. This is the first prospective randomized study comparing sub-Tenon's versus retrobulbar anesthesia for glaucoma surgery. METHODS:Thirty-nine patients undergoing both inpatient and day surgery tr...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(93)31440-5
更新日期:1993-10-01 00:00:00
abstract:PURPOSE:The purpose of this study is to determine the effect of loop fixation and anterior capsular tears on intraocular lens (IOL) decentration. METHODS:A retrospective measurement of IOL decentration was performed on 144 human eyes with posterior chamber (PC) IOLs obtained after death. RESULTS:Decentration in eyes ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31677-5
更新日期:1993-02-01 00:00:00
abstract:PURPOSE:To present a case series of ocular findings of West Nile virus infection (WNVI) in North America. DESIGN:Retrospective, noncomparative, observational case series. PARTICIPANTS:All patients were referred to the authors for WNVI with ocular involvement between the years 2002 and 2005. METHODS:Chart review was ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.04.021
更新日期:2006-09-01 00:00:00
abstract:PURPOSE:To analyze the prevalence, incidence, and clinical characteristics of eyes with geographic atrophy (GA) in age-related macular degeneration (AMD), including clinical and genetic factors affecting enlargement. DESIGN:Prospective cohort study within a controlled clinical trial. PARTICIPANTS:Age-Related Eye Dise...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2018.05.028
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Oral trans-retinoic acid has recently been shown to be an effective treatment modality for acute promyelocytic leukemia. This type of drug differs from traditional tumoricidal agents by promoting differentiation of the malignant, immature cells. METHODS:The authors describe a patient with optic nerve infilt...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31783-x
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVE:To compare the effect of bimatoprost and the fixed combination of latanoprost and timolol (LTFC) on 24-hour mean intraocular pressure (IOP) after patients are switched from a nonfixed combination of latanoprost and timolol. DESIGN:Randomized, double-masked, multicenter clinical trial. PARTICIPANTS:Two hundr...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2007.01.025
更新日期:2007-12-01 00:00:00
abstract::A 21-year-old man with known Castleman's disease, a lymphoproliferative disorder with both local and systemic manifestations, presented with decreased vision in the left eye and chromatopsia. He had infiltration of the left disc and choroid with elevation of the retina, multiple bilateral depigmented areas at the leve...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32674-1
更新日期:1989-11-01 00:00:00
abstract::An ultrasound diagnostic coding system was developed that permitted entry of diagnoses into a programmable calculator, thus permitting rapid information retrieval of patients with a specific diagnosis or diagnoses as well as the number of patients with a specific diagnosis. Cataract, vitreous opacity, trauma, choroida...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(78)35564-0
更新日期:1978-11-01 00:00:00
abstract::We studied the macrostructural characteristics of papillary changes of the upper tarsal conjunctiva associated with the wearing of polymethyl methacrylate (PMMA) contact lenses. Fifty subjects with elevated conjunctival papillae greater than 0.3 mm in diameter were studied. Macrostructural characteristics recorded wer...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)34899-4
更新日期:1981-11-01 00:00:00
abstract::The objective of the study is to present evidence that some people with 20/200 visual acuity and a field of vision greater than 120 degrees can drive safely in the daytime at a speed of not more than 40 mph. Eight individuals with 20/200 visual acuity (legally blind) were tested for the distance at which they could re...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32704-7
更新日期:1989-10-01 00:00:00
abstract::Diagnostic anterior chamber and vitreous aspiration confirmed an infectious etiology in 78 of 140 eyes (56%) with suspected endophthalmitis. In 27 eyes the vitreous aspirate was positive, while the anterior chamber aspirate was negative. Intraocular antibiotics were used in 88 eyes including 50 which underwent therape...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35241-x
更新日期:1980-04-01 00:00:00
abstract:OBJECTIVE:To describe a simple and noninvasive technique to manage conjunctival prolapse and to report its efficacy. DESIGN:Noncomparative, retrospective case series. PARTICIPANTS:Ten consecutive patients encountered over a span of 13 years developed postoperative conjunctival prolapse as a complication from various ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(99)00520-5
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy of a combination of 5-fluorouracil (5FU) and low-molecular-weight heparin (LMWH) in the treatment of unselected rhegmatogenous retinal detachment (RRD) undergoing primary vitrectomy. DESIGN:Double-masked, prospective, randomized, placebo-controlled clinical trial. PARTICIPANTS:Six ...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2006.08.042
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:To investigate microstructures in patients with genetically confirmed Bowman's layer dystrophies (Thiel-Behnke or Reis-Bücklers corneal dystrophy) using an in vivo laser scanning confocal microscope. DESIGN:Single-center, prospective, comparative small case series. PARTICIPANTS:Two patients from one pedigre...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.05.076
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:We studied the 3-year efficacy and safety results of a 4-year study evaluating fluocinolone acetonide (FA) intravitreal implants in eyes with persistent or recurrent diabetic macular edema (DME). DESIGN:Prospective, evaluator-masked, controlled, multicenter clinical trial. PARTICIPANTS:We included 196 eyes wi...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2011.02.048
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To analyze hyperreflective foci typically seen in diabetic macular edema (DME) in optical coherence tomography (OCT). DESIGN:Prospective clinical trial. PARTICIPANTS:Twelve consecutive patients with treatment-naïve, clinically significant DME. METHODS:During a same-day examination, a standardized visual acui...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ophtha.2008.12.039
更新日期:2009-05-01 00:00:00
abstract::A prospective, randomized, double-masked, placebo-controlled clinical trial was conducted to study the effects of oral acyclovir on 55 patients with acute herpes zoster ophthalmicus. Treatment with oral acyclovir resulted in more prompt resolution of signs and symptoms, particularly in patients treated within 72 hours...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(85)33842-3
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the intraocular pressure (IOP) reduction achieved by the most frequently prescribed antiglaucoma drugs in patients with normal tension glaucoma (NTG). DESIGN:Systematic review and meta-analysis. PARTICIPANTS:Fifteen randomized clinical trials reported 25 arms for peak IOP reduction, 16 arms for ...
journal_title:Ophthalmology
pub_type: 杂志文章,meta分析
doi:10.1016/j.ophtha.2009.01.036
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:The effect of severing the check ligaments and intermuscular membranes on the dose-response curve for medial rectus recessions in patients with infantile esotropia has not been previously studied by randomized assignment techniques using contemporary control and experimental groups and masked precautions. M...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(93)31550-2
更新日期:1993-06-01 00:00:00
abstract:PURPOSE:To determine the prevalence of and factors associated with diabetic retinopathy (DR) among non-Indigenous and Indigenous Australian adults with self-reported diabetes. DESIGN:Population-based cross-sectional study. PARTICIPANTS:Non-Indigenous Australians (50-98 years of age) and Indigenous Australians (40-92 ...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2017.02.004
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:To describe the safety and effectiveness of using autologous serum-based eye drops for the treatment of severe dry eye and persistent corneal epithelial defect. METHODS:Literature searches of the PubMed and Cochrane Library databases were conducted most recently in March 2019. The searches identified 281 citat...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.ophtha.2019.08.018
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To evaluate two indices generated from measurements obtained from the Orbscan Corneal Topography System (CTS; Orbscan, Inc., Salt Lake City, UT) to distinguish contact lens-induced corneal thinning from keratoconus. The corneal thickness index (CTI) was used to compare central and peripheral corneal thicknesses...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(02)01276-9
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:The ability to detect reticular pseudodrusen (RPD)/subretinal drusenoid deposits (SDDs) using 12×12-mm widefield en face swept-source optical coherence tomography (SS-OCT) imaging was compared with conventional multimodal imaging (color, fundus autofluorescence (FAF), and infrared reflectance [IR] imaging) in e...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.10.009
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To describe patient characteristics, classification, and onset of prethreshold retinopathy of prematurity (ROP), and ocular findings at 6 months corrected age in infants with birth weights <500 g who were enrolled in the Early Treatment for Retinopathy of Prematurity (ETROP) Study. DESIGN:Multicenter randomize...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2010.09.031
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To compare diabetic retinopathy (DR) identification and ungradable image rates between nonmydriatic ultrawide field (UWF) imaging and nonmydriatic multifield fundus photography (NMFP) in a large multistate population-based DR teleophthalmology program. DESIGN:Multiple-site, nonrandomized, consecutive, cross-se...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2016.01.043
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:To assess blindness prevalence and that caused specifically by cataract in rural southern China. DESIGN:Population-based, cross-sectional study. PARTICIPANTS:A total of 5342 persons older than 50 years of age. METHODS:Visual acuity and eye examinations were performed in the summer of 1997 in a random sample ...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0161-6420(99)90459-1
更新日期:1999-08-01 00:00:00