Abstract:
OBJECTIVE:To evaluate the ability of stereoscopic nonmydriatic digital retinal imaging to detect ocular pathologic features other than diabetic retinopathy (DR) in patients with diabetes mellitus (DM) compared with dilated retinal examination by retinal specialist ophthalmologists. DESIGN:Clinic-based comparative instrument study and retrospective chart review. PARTICIPANTS:Two hundred eighty Joslin Diabetes Center outpatients (560 eyes) with type 1 or type 2 DM. METHODS:Nonsimultaneous stereoscopic nonmydriatic digital retinal images (640 x 480 pixels) of three 45 degrees retinal fields were acquired and graded for clinical level of DR and other ocular pathologic features by certified readers according to Joslin Vision Network (JVN) protocol. Retrospective chart review compared findings from JVN digital images with findings from dilated retinal examination by retinal specialists performed within an average of 39.6 days of digital imaging. An independent senior retinal specialist adjudicated disagreements by review of 7 standard field 35-mm Early Treatment Diabetic Retinopathy Study protocol fundus photographs and JVN images. MAIN OUTCOME MEASURES:Detection of non-DR ocular pathologic features by digital imaging as compared with clinical examination. RESULTS:Nonmydriatic digital evaluation identified at least 1 non-DR ocular finding in 40.7% of patients (114/280). Non-diabetes mellitus ocular pathologic features identified by digital images, clinical examination, or both included cataract (n = 100); age-related maculopathy (n = 52); suspicion of glaucoma (n = 18); choroidal lesions (n = 18); evidence of systemic disorder (e.g., hypertension or renal disease; n = 15); epiretinal membrane (n = 11); chorioretinal atrophy, scar, or both (n = 6); retinal emboli (n = 3); retinitis pigmentosa (n = 1); and asteroid hyalosis (n = 1). Agreement of nonmydriatic imaging with clinical examination for presence and absence of these findings was 95.4%, 91.3%, 98.2%, 98.6%, 98.2%, 99.6%, 100%, 100%, 100%, and 100%, respectively. Kappa values for all non-DR lesions demonstrated near perfect agreement (kappa> or =0.80) except for age-related maculopathy (kappa = 0.71) and choroidal lesions (kappa = 0.73), where agreement was substantial. Overall, only 55 eyes (9.8%) were ungradable for level of DR and 85 eyes (15.2%) were ungradable for macular edema. CONCLUSIONS:Joslin Vision Network nonmydriatic digital imaging demonstrated excellent agreement with dilated ophthalmic examination by retinal specialists in the detection of ocular disease other than DR, suggesting a potential role for this technology in evaluating non-DR disorders and highlighting the extent of findings other than retinopathy in patients with diabetes.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Chow SP,Aiello LM,Cavallerano JD,Katalinic P,Hock K,Tolson A,Kirby R,Bursell SE,Aiello LPdoi
10.1016/j.ophtha.2005.12.025subject
Has Abstractpub_date
2006-05-01 00:00:00pages
833-40issue
5eissn
0161-6420issn
1549-4713pii
S0161-6420(06)00083-2journal_volume
113pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:BACKGROUND:Cytomegalovirus (CMV) and Toxoplasma gondii both cause necrotizing retinopathy in immunosuppressed hosts. Because of the high prevalence of serum antibodies to these agents in the general population and the risks associated with retinal biopsies, diagnosis of these infections is usually based on clinical fin...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(13)31267-6
更新日期:1994-03-01 00:00:00
abstract:PURPOSE:To provide a set of surveillance guidelines for children at risk for development of retinoblastoma. DESIGN:Consensus panel. PARTICIPANTS:Expert panel of ophthalmic oncologists, pathologists, and geneticists. METHODS:A group of members of the American Association of Ophthalmic Oncologists and Pathologists (AA...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2017.09.001
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To determine which subjects need close glycemic monitoring during intravenous pulse methylprednisolone therapy for eye disease. DESIGN:Retrospective study in a national eye center. PARTICIPANTS:Two hundred twenty-four subjects who received over a one-year period 250 to 1000 mg daily intravenous methylpredniso...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00818-2
更新日期:2003-12-01 00:00:00
abstract:PURPOSE:To determine the impact that cataract and cataract surgery have on clinical measurements of vision, reading speed, objective mobility performance, and subjective visual functioning. DESIGN:Prospective, population-based study. PARTICIPANTS:A total of 1739 Salisbury Eye Evaluation (SEE) participants without pre...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.10.009
更新日期:2013-05-01 00:00:00
abstract::Neuropathic pain is caused by a primary lesion or dysfunction of the nervous system and can occur in the cornea. However, neuropathic corneal pain (NCP) is currently an ill-defined disease. Patients with NCP are extremely challenging to manage, and evidence-based clinical recommendations for the management of patients...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.ophtha.2017.08.004
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To evaluate optical coherence tomography (OCT), a novel noncontact and noninvasive imaging technique, for the diagnosis and quantitative characterization of epiretinal membranes. METHODS:Optical coherence tomography is similar to an ultrasound B-scan, except that light rather than sound is used, which enable...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(96)30377-1
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:The authors prospectively studied visual outcome, relapse, complications, and survival of patients with acquired immune deficiency syndrome (AIDS)-related cytomegalovirus (CMV) treated with high-dose intravitreous ganciclovir (2 mg/0.1 ml) injections. The outcomes were compared with those of patients treated ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(98)98020-4
更新日期:1998-08-01 00:00:00
abstract:PURPOSE:One assumption of the uniocular drug trial in glaucoma management is that fellow-eye pairs exhibit symmetric intraocular pressure (IOP) responses when both eyes are treated with the same topical IOP-lowering medication. The purpose of this study was to determine if this assumption is true. DESIGN:Observational...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2004.11.028
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:To investigate when retinal pigment epithelium (RPE) tears occur and their associated treatment patterns and long-term visual outcomes in patients with neovascular age-related macular degeneration (nAMD) during anti-vascular endothelial growth factor (VEGF) treatment. DESIGN:Case-control analysis from a prospe...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2017.08.039
更新日期:2018-02-01 00:00:00
abstract::Warburg syndrome is a congenital oculocerebral disorder. It is caused by a genetic defect that simultaneously affects ocular and cerebral embryogenesis. The characteristic ophthalmic findings reflect the cerebral malformation (agyria or lissencephaly). Two cases, siblings, have been described. The characteristic bilat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(83)34345-1
更新日期:1983-12-01 00:00:00
abstract:OBJECTIVE:To measure accuracy and reliability of the computer-based Retinal Image Multiscale Analysis (RISA) system compared with those of recognized retinopathy of prematurity (ROP) experts, for plus disease diagnosis. DESIGN:Evaluation of diagnostic test or technology. PARTICIPANTS:Eleven recognized ROP experts and...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.10.006
更新日期:2007-12-01 00:00:00
abstract::Iris (eye) color was examined for its effect on eye disease in a population-based study of diabetic retinopathy in Wisconsin. Eye color was determined by comparing the iris in a red reflex photograph with standard photographs. In younger-onset diabetic persons (N = 996), macular edema was more prevalent in persons wit...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)80004-0
更新日期:1987-10-01 00:00:00
abstract:PURPOSE:To evaluate the long-term success rate of vitreoretinal surgery for severe cases of retinal capillary hemangiomas (RCHs) caused by von Hippel-Lindau (VHL) disease. DESIGN:Retrospective case series. PARTICIPANTS:Twenty-three eyes of 21 patients with severe exudative or tractional retinal detachment caused by R...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.04.031
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:To determine in vivo confocal microscopy diagnostic criteria to diagnose Acanthamoeba keratitis (AK) using polymerase chain reaction (PCR) as the reference diagnostic technique. DESIGN:Retrospective case-control study. Data were recorded prospectively and analyzed retrospectively. PARTICIPANTS:Fifty patients ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2017.08.037
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:This article presents three patients with endophthalmitis associated with infection with Capnocytophaga species. METHODS:The medical records of three patients with culture-positive Capnocytophaga endophthalmitis were reviewed. A panel of isolates of Capnocytophaga were then tested for sensitivity to third-gene...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31622-2
更新日期:1993-04-01 00:00:00
abstract:OBJECTIVE:The purpose of the study was to measure the effect of the topical carbonic anhydrase inhibitor, 2% dorzolamide hydrochloride, on the rate of aqueous humor flow in sleeping humans. DESIGN:A randomized, double-masked, placebo-controlled study. PARTICIPANTS:Twenty-five normal human subjects. INTERVENTION:Topi...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0161-6420(98)98043-5
更新日期:1998-08-01 00:00:00
abstract::Sixty-four consecutive patients with aphakic penetrating keratoplasty and penetrating keratoplasty combined with intracapsular cataract extraction were reviewed in a prospective fashion with a minimum of a one-year follow-up. Five were lost to follow-up. There were seven graft failures at the end of one year. Five of ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35187-7
更新日期:1980-07-01 00:00:00
abstract::Methods of testing for lacrimal drainage insufficiency and a modification of the Jones fluorescein dye tests are presented. Despite their excellence, Jones tests have never been widely employed because of difficulty in dye retrieval. The modification consists of instilling one drop of the dye three times at 15 second ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(78)35559-7
更新日期:1978-12-01 00:00:00
abstract:PURPOSE:To evaluate the short-term and long-term variability of intraocular pressure (IOP) in eyes with primary open-angle glaucoma. DESIGN:Prospective study. PARTICIPANTS:Twenty-two patients previously implanted with a sulcus-based IOP sensor (EyeMate, Implandata GmbH, Germany). METHODS:Twenty-two patients previous...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2020.07.016
更新日期:2021-02-01 00:00:00
abstract:PURPOSE:To generate wide-field automated seamless retinal montage images. DESIGN:Prospective, observational, case series study. PARTICIPANTS:Eighteen eyes of 14 patients were studied. INTERVENTION:A digital scanning laser ophthalmoscope (SLO), the Heidelberg Retina Angiograph (HRA), was used to obtain overlapping im...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(99)90529-8
更新日期:1999-12-01 00:00:00
abstract:PURPOSE:To determine the increase in isopter extent, resulting from the measurement of, and correction for, individual reaction time (RT; the latency between stimulus presentation and individual patient response), derived under the standardized conditions of semi-automated kinetic perimetry (SKP), and to model the age-...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.09.030
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVES:To determine the proportion of all Myocilin coding mutations responsible for advanced primary open-angle glaucoma (POAG) in early-age-at-onset individuals and to investigate the prevalence of exon 3 Myocilin mutations in advanced POAG at any age at onset in a large Australasian cohort. DESIGN:Cross-sectiona...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.11.029
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:To assess the immediate effect of laser peripheral iridotomy (LPI) and mechanisms of angle closure in a population-based study of primary angle closure (PAC) suspects. DESIGN:Prospective interventional study. PARTICIPANTS:People identified as PAC suspects aged 50 to 79 years from a population-based survey in ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.06.053
更新日期:2007-03-01 00:00:00
abstract:PURPOSE:To define the range and life cycles of cuticular drusen phenotypes using multimodal imaging and to review the histologic characteristics of cuticular drusen. DESIGN:Retrospective, observational cohort study and experimental laboratory study. PARTICIPANTS:Two hundred forty eyes of 120 clinic patients with a cu...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2017.08.033
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To investigate whether confluent drusen may be accompanied by fluid accumulation underneath the sensory retina and to determine if the detection of subretinal fluid on spectral-domain optical coherence tomography (OCT) in patients with coalescent drusen is indicative of choroidal neovascularization (CNV). DESI...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.04.017
更新日期:2011-01-01 00:00:00
abstract::This report details the presentation, workup, and treatment of the largest lacrimal duct cyst ever reported in the ophthalmic literature. Included in this report is the first computed tomographic (CT) image of this unusual lesion. Typical and atypical clinical features of this lacrimal sac cyst are emphasized. ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33391-3
更新日期:1987-06-01 00:00:00
abstract:PURPOSE:The authors studied the coagulation cascade and fibrinolysis pathway in patients with untreated glaucoma (P = 0.00001 and P = 0.0003, respectively) and patients with normal pressure glaucoma ([NPG] P = 0.00001 and P = 0.03, respectively). METHODS:Forty-two untreated patients with NPG, 25 untreated patients wit...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30245-0
更新日期:1997-04-01 00:00:00
abstract::Dr. William O. Coffee was an ophthalmologist who conducted an office and mail-order practice in the Midwest from the 1880s until 1927. His main stock in trade was a self-discovered absorption cure for a variety of ocular diseases, with particular emphasis on the medical cure of cataracts. Dr. Coffee's career was a che...
journal_title:Ophthalmology
pub_type: 传,历史文章,杂志文章
doi:10.1016/s0161-6420(89)32758-8
更新日期:1989-08-01 00:00:00
abstract:PURPOSE:To investigate the relationship between the degree of posterior bowing of the lamina cribrosa (LC) at baseline and the rate of subsequent visual field (VF) progression in eyes with primary open-angle glaucoma (POAG). DESIGN:Prospective, observational study. PARTICIPANTS:One hundred one early-stage (VF mean de...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2018.05.017
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the reproducibility of optical coherence tomograph (OCT) retinal nerve fiber layer (RNFL) measurements in normal and glaucomatous eyes by means of the commercially available OCT 2000 instrument (Humphrey Systems, Dublin, CA). DESIGN:Prospective instrument validation study. PARTICIPANTS:One eye e...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(00)00341-9
更新日期:2000-12-01 00:00:00