Alkylating benzamides with melanoma cytotoxicity.

abstract：:Preoperative assessment of melanoma invasion by sonometry has been reported to exhibit a high correlation with postoperative histometry based on the determination of a regression coefficient. We believe that this approach is not adequate and that it can be misleading. We therefore applied an appropriate statistical ap...

journal_title：Melanoma research

authors： Partsch B,Binder M,Püspök-Schwarz M,Wolff K,Pehamberger H

更新日期：1996-10-01 00:00:00

abstract：:We examined the incidence of primary invasive melanoma in the municipality of Reggio Emilia, northern Italy, in the period from 1986 to 1997. We identified 169 cases, five of which were intraocular. After adjustment for confounders, the risk of having a thick melanoma (Breslow > or = 1 mm) did not decrease over time, ...

journal_title：Melanoma research

authors： Vinceti M,Bergomi M,Borciani N,Serra L,Vivoli G

更新日期：1999-02-01 00:00:00

abstract：:Cerebral metastases from melanoma are correlated with a poor prognosis. Temozolomide is an oral alkylating agent that can cross the blood-brain barrier and in phase II and III trials, patients with advanced metastatic melanoma achieved overall response rates of 13 to 21%. The present study evaluated the efficacy and t...

journal_title：Melanoma research

authors： Bafaloukos D,Tsoutsos D,Fountzilas G,Linardou H,Christodoulou C,Kalofonos HP,Briassoulis E,Panagiotou P,Hatzichristou H,Gogas H

更新日期：2004-08-01 00:00:00

abstract：:Dermatologic toxicity is a known reaction of ipilimumab and vemurafenib. Because of the lack of effective treatments and aggressive nature of melanoma, treatments are often discontinued and new treatments are initiated in rapid succession. We report what we believe to be the first case of cumulative dermatologic toxic...

journal_title：Melanoma research

authors： Ludlow SP,Pasikhova Y

更新日期：2013-12-01 00:00:00

abstract：:Germline mutations determining increased cutaneous malignant melanoma (CMM) risk have been identified in familial and sporadic CMM cases, but they account only for a small proportion of CMM cases. Recent evidence suggests that germline epimutations (e.g. DNA methylation alterations), which can be inherited similarly t...

journal_title：Melanoma research

authors： Pergoli L,Favero C,Pfeiffer RM,Tarantini L,Calista D,Cavalleri T,Angelici L,Consonni D,Bertazzi PA,Pesatori AC,Landi MT,Bollati V

更新日期：2014-10-01 00:00:00

abstract：:Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, amongst other carcinomas, in a substantial subset of primary melanomas, with a preponderance of mutations within the kinase domain, including the activating V599E and V599K transitions. We investigated a representative series of 54 r...

journal_title：Melanoma research

authors： Kirschner M,Helmke B,Starz H,Benner A,Thome M,Deichmann M

更新日期：2005-10-01 00:00:00

abstract：:Glutathione (GSH) is the major non-protein thiol in cells that plays a critical role against damage from electrophilic agents such as alkylating drugs. Selective therapeutic GSH elevation in normal but not in tumour cells has been suggested as a means of protecting host tissues against more intense doses of chemothera...

journal_title：Melanoma research

authors： del Olmo M,Alonso-Varona A,Castro B,Calle Y,Bilbao P,Palomares T

更新日期：2000-04-01 00:00:00

abstract：:An increased risk of melanoma has been variously reported in patients with chronic lymphocytic leukaemia (CLL), analogous with other immunosuppressed populations. To fully assess this association, we performed a systematic review and meta-analysis of available evidence from observational cohort studies. All such longi...

journal_title：Melanoma research

authors： Olsen CM,Lane SW,Green AC

更新日期：2016-04-01 00:00:00

abstract：:The EORTC Melanoma Cooperative Group conducted a phase II trial (study number 18891) to study the effect of Toremifene in 45 patients with advanced, metastatic melanoma. Male and female patients, median age 61 (range 23-88) years received a mean total dose of 11 g (4.3-62.6) orally for at least 6 weeks. No objective r...

journal_title：Melanoma research

authors： Kleeberg UR,Engel E,Bröcker EB,Avril F,Israels P,Weiss J,Kangas L,van Glabbeke M,Lentz MA

更新日期：1993-04-01 00:00:00

abstract：:Two human melanoma tumour cell lines, one radiation resistant and one radiation sensitive, were studied for their capacity for repair of sublethal radiation damage (SLDR) and for hyperthermia inhibition of radiation damage. The most resistant cell line demonstrated a survival curve with a large shoulder and a large SL...

journal_title：Melanoma research

authors： Raaphorst GP,Mao JP,Ng CE

更新日期：1994-06-01 00:00:00

abstract：:Among patients with advanced melanoma, the development of autoimmune phenomena or of hypothyroidism during therapy has been associated with a favourable outcome. The objective of this study was to determine the prevalence of autoimmunity and of hypothyroidism in the melanoma population as a whole and to determine if t...

journal_title：Melanoma research

authors： Ellerhorst JA,Cooksley CD,Grimm EA

更新日期：2001-12-01 00:00:00

abstract：:Interleukin-24 (IL-24)/melanoma differentiation-associated gene-7 (mda-7) is a unique cytokine-tumor suppressor that displays ubiquitous antitumor properties and tumor-specific killing activity. Oncostatin M (OSM) is the most active IL-6-type cytokine and inhibits the proliferation of various solid tumor cell lines. M...

journal_title：Melanoma research

authors： Xu Y,Zhang F,Qin L,Miao J,Sheng W,Xie Y,Xu X,Yang J,Qian H

更新日期：2014-02-01 00:00:00

abstract：:Melanomas are promising targets for immunotherapy, as they express a number of tissue-specific antigens against which immune responses can be elicited. We have previously described transgenic mice in which malignant cutaneous melanomas are produced. The 1042 melanoma cell line, derived from a primary melanoma in one o...

journal_title：Melanoma research

authors： Milling SW,Sai T,Silvers WK,Mintz B

更新日期：2004-12-01 00:00:00

abstract：:Patients with brain metastases (BM) from melanoma have an overall survival (OS) of 2-6 months after whole-brain radiotherapy. Targeted therapy (TT) is an effective treatment for BRAF-mutated metastatic melanoma. Moreover, recent studies indicate intracranial responses of TT in patients with BM. We analyzed 146 patient...

journal_title：Melanoma research

authors： Geukes Foppen MH,Boogerd W,Blank CU,van Thienen JV,Haanen JB,Brandsma D

更新日期：2018-04-01 00:00:00

abstract：:The growth rate (GR) of melanomas is not uniform. A fast-growing subtype has been identified and seems to have a role in the stabilization of the mortality rates because of melanoma. To examine features associated with fast-growing melanomas (FGMs) and to determine the relationship between the GR and well-recognized p...

journal_title：Melanoma research

authors： Martorell-Calatayud A,Nagore E,Botella-Estrada R,Scherer D,Requena C,Serra-Guillén C,Llombart B,Sanmartin O,Kumar R,Guillén C

更新日期：2011-04-01 00:00:00

abstract：:The aim of this study was to evaluate S100B in bone marrow (BM) plasma from malignant melanoma patients. BM aspirates and peripheral blood (PB) plasma from 56 patients and BM aspirates from 29 healthy volunteers were collected. S100B was measured using an immune radiometric assay, which is a two-site sandwich assay ba...

journal_title：Melanoma research

authors： Faye RS,Paus E,Maelandsmo GM,Berner A,Høifødt HK,Fodstad Ø,Aamdal S

更新日期：2008-04-01 00:00:00

abstract：:Genes in the S100 family are abnormally expressed in a variety of tumor cells and are associated with clinical pathology, but their prognostic value in melanoma patients has not yet been fully elucidated. In this study, we extracted and profiled S100 family mRNA expression data and corresponding clinical data from the...

journal_title：Melanoma research

authors： Xiong TF,Pan FQ,Li D

更新日期：2019-02-01 00:00:00

abstract：:For primary melanoma, there is a delay between the initial skin biopsy and sentinel lymph node dissection, which may cause anxiety for the patient. The consequences of this delay on disease progression are unknown. The goal of this study was to determine whether delay time for sentinel node dissection from the initial...

journal_title：Melanoma research

authors： Parrett BM,Accortt NA,Li R,Dosanjh AS,Thummala S,Kullar R,Cleaver JE,Kashani-Sabet M,Leong SP

更新日期：2012-10-01 00:00:00

abstract：:We have observed that an early increase in the CD4+/CD8+ ratio of metastatic melanoma patients during chemoimmunotherapy is the most favourable independent prognostic factor. In this study, 87 patients with metastatic melanoma were monitored for peripheral blood lymphocyte subsets (CD4+ and CD8+) before and during che...

journal_title：Melanoma research

authors： Hernberg MM,Hahka-Kemppinen MH,Pyrhönen SO

更新日期：2004-12-01 00:00:00

abstract：:To date, no study of melanoma patients who have undergone delayed lymph node dissection (DLND) has focused on the independent prognostic factors of overall survival, as calculated from surgery on the primary. Using Kaplan-Meier estimates and Cox's proportional hazard model, the significance of prognostic factors was e...

journal_title：Melanoma research

authors： Kretschmer L,Preusser KP,Marsch WC,Neumann C

更新日期：2000-10-01 00:00:00

abstract：:In order to investigate the effects of in vivo treatment with interferon-alpha (IFN-alpha) on melanoma antigens, a clinical EORTC trial (No. 18852) was accompanied by an immunohistological study. Twenty patients with melanoma metastases of skin and soft tissues, eventually also of the lung, who were treated with syste...

journal_title：Melanoma research

authors： von Stamm U,Bröcker EB,von Depka Prondzinski M,Ruiter DJ,Rümke P,Broding C,Carrel S,Lejeune FJ

更新日期：1993-06-01 00:00:00

abstract：:Anecdotal cases of partial or complete responses have been reported after ipilimumab therapy for stage IV melanoma with brain metastasis treated earlier by surgery or radiosurgery. We report the first case of ipilimumab monotherapy resulting in durable complete remission of untreated, progressive brain metastases in a...

journal_title：Melanoma research

authors： Schartz NE,Farges C,Madelaine I,Bruzzoni H,Calvo F,Hoos A,Lebbé C

更新日期：2010-06-01 00:00:00

abstract：:Melanoma is the most lethal skin tumor in large part because of a propensity for early metastasis. Good models of this most clinically relevant feature of melanoma are lacking. Here, we report the development of an in-vivo model of metastasis that relies on orthotopic injection of green fluorescent protein-tagged line...

journal_title：Melanoma research

authors： Rozenberg GI,Monahan KB,Torrice C,Bear JE,Sharpless NE

更新日期：2010-10-01 00:00:00

abstract：:The retinoblastoma protein (pRb) pathway is critical in regulating the G1 phase of the cell cycle and it is frequently disrupted in human cancers. Components of the pRb pathway which are often altered in tumour progression include the INK4 cyclin-dependent kinase (CDK) inhibitors p16INK4a/ CDKN2A and p15INK4b/CDKN2B, ...

journal_title：Melanoma research

authors： Rizos H,Darmanian AP,Indsto JO,Shannon JA,Kefford RF,Mann GJ

更新日期：1999-02-01 00:00:00

abstract：:Identifying groups of subjects at high risk for the development of melanoma is crucial for the early diagnosis of curable tumours. In the present study, we performed a skin examination in a group of 63 patients followed up after treatment of germ cell tumours (GCTs) who were referred to the dermatologist for multiple ...

journal_title：Melanoma research

authors： Avril MF,Chompret A,Verne-Fourment L,Terrier-Lacombe MJ,Spatz A,Fizazi K,Bressac-de Paillerets B,Demenais F,Théodore C

更新日期：2001-04-01 00:00:00

abstract：:Between 6 and 14% of malignant melanomas have been reported to occur in a familial pattern. In this study 785 melanoma patients from the Victorian Melanoma Service and the private practice of a dermatologist were assessed for the total number of melanocytic naevi, the number of dysplastic naevi and other clinical char...

journal_title：Melanoma research

authors： Ang CG,Kelly JW,Fritschi L,Dowling JP

更新日期：1998-10-01 00:00:00

abstract：:Microsatellite instability (MSI) is caused by replication errors due to deficient DNA mismatch repair and has been associated with tumour progression in various types of cancer. Controversial results have been reported concerning the frequency and significance of MSI in malignant melanoma. In this study, the time of o...

journal_title：Melanoma research

authors： Palmieri G,Ascierto PA,Cossu A,Colombino M,Casula M,Botti G,Lissia A,Tanda F,Castello G

更新日期：2003-04-01 00:00:00

abstract：:Electroporation therapy (EPT) is a novel treatment modality that uses brief, high-intensity, pulsed electrical currents to enhance the uptake of chemotherapeutic agents, vaccines and genes into cells. This technique is potentially useful for patients with secondary and, possibly, some primary tumours. Nineteen patient...

journal_title：Melanoma research

authors： Byrne CM,Thompson JF,Johnston H,Hersey P,Quinn MJ,Michael Hughes T,McCarthy WH

更新日期：2005-02-01 00:00:00

abstract：:Locally advanced cutaneous melanoma has marked quality-of-life implications; however, the patient experience of symptom management and subsequent impact on quality of life has not been well described. This study aims to address the impact on patients of advanced cutaneous melanoma through qualitative interviews. Adult...

journal_title：Melanoma research

authors： Weitman ES,Perez M,Thompson JF,Andtbacka RHI,Dalton J,Martin ML,Miller T,Gwaltney C,Sarson D,Wachter E,Zager JS

更新日期：2018-04-01 00:00:00

abstract：:Ninety primary melanoma patients were studied to investigate the importance of adopting the simultaneous use of patent blue dye (PBD) and lymphoscintigraphy plus gamma detection probe to locate the sentinel node (SN). In total 135 SNs in 105 basins were visualized preoperatively under a gamma camera after lymphoscinti...

journal_title：Melanoma research

authors： Testori A,Bartolomei M,Grana C,Mezzetti M,Chinol M,Mazzarol G,Lazzari I,Paganelli G,Geraghty JG,Andreoni B,Veronesi U

更新日期：1999-12-01 00:00:00