Treatment of presbyopia with conductive keratoplasty: six-month results of the 1-year United States FDA clinical trial.


PURPOSE:To provide 6-month results of a 1-year clinical trial evaluating conductive keratoplasty (CK) for the treatment of presbyopic symptoms in emmetropic and hyperopic eyes. METHODS:A total of 143 patients with presbyopic symptoms were enrolled in this 1-year United States FDA clinical trial and treated to improve near vision in 1 eye (unilateral treatment). In addition, 33 fellow eyes were treated to improve distance vision (bilateral treatment). For near vision correction, the target refraction was up to -2.0 D in the nondominant eye, and for distance vision correction, 0.0 D. Enrolled patients had a preoperative spherical equivalent of plano to +2.00 D, no more than 0.75 D of refractive astigmatism, and were 40 years of age or older. No retreatments were performed. RESULTS:Of the eyes treated for near, 77% had uncorrected near vision of J3 or better at 6 months postoperatively. A total of 85% of all patients had binocular distance UCVA of 20/25 or better along with J3 or better near, a combination that represents functional acuity for a presbyope. Sixty-six percent of eyes treated for near had a manifest refractive spherical equivalent (MRSE) within +/- 0.50 D of intended at 6 months. In 89% of eyes, the MRSE changed 0.05 D or less between 3 and 6 months postoperatively. After month 1, the incidence of variables associated with safety was 1% or lower. Seventy-six percent were very satisfied or satisfied with their procedure. CONCLUSIONS:CK appears to be very safe and effective in producing functional visual acuity in presbyopic eyes up to 6 months following the procedure. Patient satisfaction with the procedure is similar to that of monovision LASIK.






McDonald MB,Durrie D,Asbell P,Maloney R,Nichamin L




Has Abstract


2004-10-01 00:00:00
















  • Intraocular lens exchange 1 week after descemet stripping automated endothelial keratoplasty.

    abstract:PURPOSE:To report a case of intraocular lens (IOL) exchange performed 1 week after Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS:Describe the clinical findings and outcome of IOL exchange in an 80-year-old man with pseudophakic bullous keratopathy and retained Artisan (Ophtec BV, Groningen, th...


    pub_type: 杂志文章


    authors: Lapenna L,Kadyan A,Busin M

    更新日期:2010-02-01 00:00:00

  • Axenfeld's anomaly associated with Down's syndrome.

    abstract::We report a case of a patient with Down's syndrome and keratoconus with acute hydrops who was incidentally noted to have Axenfeld's anomaly. We also review the systemic abnormalities associated with Axenfeld's anomaly and the implications of the diagnosis. To our knowledge, Axenfeld's anomaly has not previously been r...


    pub_type: 杂志文章


    authors: Stokes DW,Parrish CM

    更新日期:1992-03-01 00:00:00

  • Corneal Fine Needle Diathermy With Adjuvant Bevacizumab to Treat Corneal Neovascularization in Children.

    abstract:PURPOSE:To report the outcomes of corneal fine needle diathermy (FND) with adjuvant intrastromal and subconjunctival bevacizumab injection for corneal neovascularization (CN) in children. METHODS:Medical records of all children who had undergone FND with adjuvant bevacizumab injection were reviewed retrospectively. Tr...


    pub_type: 杂志文章


    authors: Elbaz U,Mireskandari K,Shen C,Ali A

    更新日期:2015-07-01 00:00:00

  • Antimicrobial activity of antibiotic-treated amniotic membrane: An in vitro study.

    abstract:PURPOSE:To investigate if amniotic membrane incubated with antibiotics could inhibit bacterial growth in vitro. METHODS:Amniotic membrane fragments were incubated with the antibiotics (netilmicin) solution; the washed and drained fragments were either tested after treatment or further incubated in antibiotic-free medi...


    pub_type: 杂志文章


    authors: Mencucci R,Menchini U,Dei R

    更新日期:2006-05-01 00:00:00

  • Evaluation of the Safety and Efficacy of a Low-Temperature Plasma Surgical System for Pterygium.

    abstract:PURPOSE:Surgical excision is the standard treatment for pterygium. This study was conducted to evaluate the safety and efficacy of a novel technique using low-temperature plasma (LTP) for excision and hemostasis in pterygium surgery. METHODS:A prospective, comparative, and randomized clinical trial was conducted on 60...


    pub_type: 杂志文章


    authors: Huang H,Li S,Zhong J,Wang B,Peng L,Deng Y,Wang M,Yuan J

    更新日期:2020-12-01 00:00:00

  • Comparative study of descemet stripping automated endothelial keratoplasty donor preparation by Moria CBm microkeratome, horizon microkeratome, and Intralase FS60.

    abstract:PURPOSE:To evaluate the quality of stromal bed and the safety on endothelium in preparation of donor tissue for Descemet stripping automated endothelial keratoplasty in a masked fashion using 2 mechanical microkeratomes and a femtosecond laser. METHODS:Deep anterior lamellar dissection was performed on 15 donor cornea...


    pub_type: 杂志文章


    authors: Mootha VV,Heck E,Verity SM,Petroll WM,Lakshman N,Muftuoglu O,Bowman RW,McCulley JP,Cavanagh HD

    更新日期:2011-03-01 00:00:00

  • Keratitis resulting from Thielavia subthermophila Mouchacca.

    abstract:PURPOSE:The purpose of this study was to report the first case of fungal keratitis resulting from Thielavia sp. METHODS:We conducted a retrospective chart review. RESULTS:A 10-year old girl presented 2 weeks after ocular plant injury with pain and corneal stromal infiltration with central ulceration and ill-defined m...


    pub_type: 杂志文章


    authors: Theoulakis P,Goldblum D,Zimmerli S,Muehlethaler K,Frueh BE

    更新日期:2009-10-01 00:00:00

  • Can we measure corneal biomechanical changes after collagen cross-linking in eyes with keratoconus?--a pilot study.

    abstract:PURPOSE:To assess changes in biomechanical properties of human cornea after treatment of keratoconus with UV-A-riboflavin corneal collagen cross-linking (CXL). DESIGN:Single-center, prospective, interventional study. METHODS:Ten eyes of 10 patients aged 26.5 +/- 5.7 (mean +/- SD) years with progressive keratoconus we...


    pub_type: 杂志文章


    authors: Goldich Y,Barkana Y,Morad Y,Hartstein M,Avni I,Zadok D

    更新日期:2009-06-01 00:00:00

  • Limbal Stem Cell Deficiency After Glaucoma Surgery.

    abstract:PURPOSE:To characterize the clinical presentation of limbal stem cell deficiency (LSCD) associated with glaucoma surgeries. METHODS:This is a retrospective cross-sectional study of patients with LSCD and glaucoma who presented to the Stein Eye Institute at the University of California, Los Angeles, between 2009 and 20...


    pub_type: 杂志文章


    authors: Sun Y,Yung M,Huang L,Tseng C,Deng SX

    更新日期:2020-05-01 00:00:00

  • Tolerance of Micronized Mineral Pigments for Intrastromal Keratopigmentation: A Histopathology and Immunopathology Experimental Study.

    abstract:PURPOSE:To study the tolerance and biocompatibility of mineral pigments for corneal pigmentation histopathologically and immunologically in an experimental animal model. METHODS:Manual intralamellar keratopigmentation was performed in 28 New Zealand white rabbits using micronized mineral pigments. Histopathological ex...


    pub_type: 杂志文章


    authors: Amesty MA,Rodriguez AE,Hernández E,De Miguel MP,Alio JL

    更新日期:2016-09-01 00:00:00

  • Comparison of 5% Sulfur Hexafluoride Versus 100% Air Tamponade in Descemet Membrane Endothelial Keratoplasty.

    abstract:PURPOSE:To compare the rebubbling rate and clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) with 5% sulfur hexafluoride (SF6) gas versus 100% air as a tamponade for graft attachment. METHODS:Retrospective, comparative, interventional case series including 368 consecutive pseudophakic eyes with Fu...


    pub_type: 杂志文章


    authors: Ampazas P,Droutsas K,Giallouros E,Schroeder FM,Sekundo W

    更新日期:2017-10-01 00:00:00

  • Measures for preventing recurrence after pterygium surgery.

    abstract:PURPOSE:To introduce an improved technique of pterygium surgery and to compare postoperative results between this technique and previous techniques. METHODS:In a retrospective survey, the records of 216 consecutive eyes with primary pterygium that underwent surgery by three different techniques were reviewed. The new ...


    pub_type: 杂志文章


    authors: Akura J,Kaneda S,Matsuura K,Setogawa A,Takeda K,Honda S

    更新日期:2001-10-01 00:00:00

  • Femtosecond laser-assisted inverted mushroom keratoplasty.

    abstract:PURPOSE:To evaluate best-corrected visual acuity (BCVA), refractive outcome, corneal topography, optical coherence tomography, and endothelial cell density 12 months after femtosecond laser-assisted inverted mushroom keratoplasty. METHODS:We performed a prospective study of a surgical case series of 5 patients undergo...


    pub_type: 杂志文章


    authors: Cheng YY,Tahzib NG,van Rij G,van Cleynenbreugel H,Pels E,Hendrikse F,Nuijts R

    更新日期:2008-07-01 00:00:00

  • Clostridium sordellii endophthalmitis after suture removal from a corneal transplant.

    abstract:PURPOSE:To report a case of endophthalmitis caused by Clostridium sordellii. METHODS:A 33-year-old man sustained a penetrating injury of the right eye that resulted in several ocular surgical procedures including pars plana vitrectomy, scleral buckling, scleral-sutured posterior chamber intraocular lens, and penetrati...


    pub_type: 杂志文章


    authors: Zink JM,Singh-Parikshak R,Sugar A,Johnson MW

    更新日期:2004-07-01 00:00:00

  • Laser-assisted in situ keratomileusis complications in diabetes mellitus.

    abstract:PURPOSE:To report the incidence of complications and the refractive results in patients with diabetes mellitus treated with laser-assisted in situ keratomileusis (LASIK). METHODS:A retrospective review of the charts, focusing on 6-month postoperative data, was performed on 30 eyes from patients with diabetes and 150 a...


    pub_type: 杂志文章


    authors: Fraunfelder FW,Rich LF

    更新日期:2002-04-01 00:00:00

  • Gemella haemolysans infectious crystalline keratopathy.

    abstract:PURPOSE:To report a case of infectious crystalline keratopathy caused by Gemella haemolysans. METHODS:Observational case report. A 65-year-old woman underwent penetrating keratoplasty for contact lens-related Acanthamoeba keratitis and developed a nonhealing epithelial defect. Despite continued prophylaxis with topica...


    pub_type: 杂志文章


    authors: Elmallah MK,Munir WM,Janda WM,Tu EY

    更新日期:2006-12-01 00:00:00

  • In vitro comparison of Chen medium and Optisol-GS medium for human corneal storage.

    abstract:PURPOSE:To compare paired human corneas after storage at 4 degrees C in Chen medium (CM) and Optisol-GS medium (OM) for 7, 10, 14, and 21 days. METHODS:One cornea of each pair from nine human donors was randomly stored in either CM or OM, with its mate cornea stored in the other medium. Three pairs of corneas were sto...


    pub_type: 杂志文章


    authors: Nelson LR,Hodge DO,Bourne WM

    更新日期:2000-11-01 00:00:00

  • The Effect of Intraoperative Angle Kappa Adjustment on Higher-Order Aberrations Before and After Small Incision Lenticule Extraction.

    abstract:PURPOSE:To compare higher-order aberrations (HOAs) after small incision lenticule extraction (SMILE) in patients with and without intraoperative angle kappa adjustments. METHODS:This is a retrospective case series. One hundred six eyes of 106 patients who underwent SMILE at Tianjin Eye Hospital (Tianjin Medical Univer...


    pub_type: 杂志文章


    authors: Shao T,Wang Y,Ng ALK,Chan TCY,Hao W,Zhang J,Cheng GPM,Jhanji V

    更新日期:2020-05-01 00:00:00

  • Limbal stem cell transplantation for the treatment of subepithelial amyloidosis of the cornea (gelatinous drop-like dystrophy).

    abstract:PURPOSE:Subepithelial amyloidosis of the cornea, or gelatinous drop-like corneal dystrophy (GDD), is a severe form of corneal stromal amyloidosis predominantly found in the Japanese population. GDD causes severe visual disturbances with irritating symptoms, and keratoplasty is inevitably complicated by early recurrence...


    pub_type: 杂志文章


    authors: Shimazaki J,Shimmura S,Tsubota K

    更新日期:2002-03-01 00:00:00

  • Corneal Stiffening by a Bacteriochlorophyll Derivative With Dextran and Near-Infrared Light: Effect of Shortening Irradiation Time up to 1 Minute.

    abstract:PURPOSE:The aim of this study is to determine the effect of variation of the exposure time of near-infrared irradiation on corneal stiffening after a bacteriochlorophyll derivative (WST11) with dextran (WST-D) application. METHODS:One hundred four paired eyes of 3-month-old New Zealand White rabbits were included in t...


    pub_type: 杂志文章


    authors: Brekelmans J,Goz A,Dickman MM,Brandis A,Sui X,Wagner HD,Nuijts RMMA,Scherz A,Marcovich AL

    更新日期:2017-11-01 00:00:00

  • Advances in the management of keratomycosis and Acanthamoeba keratitis.

    abstract:PURPOSE:In the late 1960s, the management of fungal keratitis was a serious unresolved problem. Little was known of the epidemiology of the disease, and there were no antifungal agents formulated for use in the eye. METHODS:A thorough review of the literature was done back to 1969 on clinical reports and experimental ...


    pub_type: 杂志文章,评审


    authors: O'Day DM,Head WS

    更新日期:2000-09-01 00:00:00

  • Potentiation by cyclic AMP of the stimulatory effect of epidermal growth factor on corneal epithelial migration.

    abstract:PURPOSE:To provide insight into the mechanism by which epidermal growth factor (EGF) stimulates corneal epithelial migration, we investigated the possible interaction between EGF and cyclic AMP (cAMP) signaling pathways during epithelial migration with an organ culture system for the rabbit cornea. METHODS:Rabbit corn...


    pub_type: 杂志文章


    authors: Nakamura M,Nishida T

    更新日期:2003-05-01 00:00:00

  • Six different mutations of TGFBI (betaig-h3, keratoepithelin) gene found in Japanese corneal dystrophies.

    abstract:PURPOSE:To investigate mutations of the human transforming growth factor beta-induced gene (TGFBI), transforming growth factor-beta-induced gene product (betaig-h3, keratoepithelin), in Japanese patients with Avellino corneal dystrophy (ACD), lattice corneal dystrophy (LCD), granular corneal dystrophy (GCD), and Reis-B...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Fujiki K,Hotta Y,Nakayasu K,Yamaguchi T,Kato T,Uesugi Y,Ha NT,Endo S,Ishida N,Lu WN,Kanai A

    更新日期:2000-11-01 00:00:00

  • Fungal keratitis caused by Chaetomium atrobrunneum.

    abstract:PURPOSE:We report a case of mycotic keratitis caused by a rare fungus Chaetomium atrobrunneum. METHODS:Clinical examination, slit-lamp examination, and microbiological evaluation of corneal ulcer were done, and its treatment outcome was studied. The fungal etiology was established by conventional microbiological techn...


    pub_type: 杂志文章


    authors: Balne PK,Nalamada S,Kodiganti M,Taneja M

    更新日期:2012-01-01 00:00:00

  • Grading of corneal and conjunctival staining in the context of other dry eye tests.

    abstract:PURPOSE:To describe the Oxford Scheme for grading ocular surface staining in dry eye and to discuss optimization of stain detection using various dyes and filters. Also, to propose a sequence of testing for dry eye diagnosis. METHODS:The grading of corneal and conjunctival staining is described, using the Oxford Schem...


    pub_type: 杂志文章,评审


    authors: Bron AJ,Evans VE,Smith JA

    更新日期:2003-10-01 00:00:00

  • Remission of antiepiligrin (laminin-5) cicatricial pemphigoid after excision of gastric carcinoma.

    abstract:PURPOSE:To describe a case of antiepiligrin cicatricial pemphigoid with unusual ocular manifestations and its remission after surgical removal of gastric carcinoma. METHODS:We describe a 61-year-old Japanese man with antiepiligrin cicatricial pemphigoid. RESULTS:He presented with conjunctival injection and discharge ...


    pub_type: 杂志文章


    authors: Uchiyama K,Yamamoto Y,Taniuchi K,Matsui C,Fushida Y,Shirao Y

    更新日期:2000-07-01 00:00:00

  • Successful transplantation of bioengineered tissue replacements in patients with ocular surface disease.

    abstract:PURPOSE:To bioengineer a corneal surface replacement using ex vivo expanded, cultured corneal epithelial stem cells seeded on a matrix derived from amniotic membrane and use this bioengineered graft to manage difficult ocular surface disease. METHODS:Fourteen patients with ocular surface disease unresponsive to standa...


    pub_type: 杂志文章


    authors: Schwab IR,Reyes M,Isseroff RR

    更新日期:2000-07-01 00:00:00

  • Clinical Characteristics and Outcomes of Ocular Cicatricial Pemphigoid: A Cohort Study and Literature Review.

    abstract:PURPOSE:Ocular cicatricial pemphigoid (OCP) is a rare systemic autoimmune disease and a potentially blinding subepithelial blistering disorder. The purpose of this study was to describe the clinical spectrum of the disease and to assess the efficacy and safety of immunosuppressive agents in a cohort of patients with OC...


    pub_type: 杂志文章,评审


    authors: Fremont F,Pelissier-Suarez C,Fournié P,Porterie M,Thevenin A,Astudillo L,Paricaud K,Gualino V,Soler V,Pugnet G

    更新日期:2019-11-01 00:00:00

  • Corneal Endothelium and Phacoemulsification.

    abstract::Phacoemulsification has become the most commonly used procedure in cataract surgery owing to the development of new devices and surgical techniques; however, corneal endothelial damage still represents a serious complication. Although several factors are known to cause corneal endothelial damage, effects of irrigating...


    pub_type: 杂志文章


    authors: Takahashi H

    更新日期:2016-11-01 00:00:00

  • A stepwise approach to donor preparation and insertion increases safety and outcome of Descemet membrane endothelial keratoplasty.

    abstract:PURPOSE:Lamellar techniques for selective replacement of diseased corneal structures have recently been improved. Descemet membrane endothelial keratoplasty (DMEK) allows the sole replacement of the endothelium--Descemet membrane layer (EDM). However, wide-spread use of DMEK is currently limited because of problems wit...


    pub_type: 杂志文章


    authors: Kruse FE,Laaser K,Cursiefen C,Heindl LM,Schlötzer-Schrehardt U,Riss S,Bachmann BO

    更新日期:2011-05-01 00:00:00