Abstract:
OBJECTIVE:To assess the potential efficacy, tolerability, and safety of citalopram in the treatment of functional pediatric recurrent abdominal pain and comorbid internalizing disorders. METHOD:Twenty-five clinically referred children and adolescents with recurrent abdominal pain aged 7 to 18 years, inclusive, participated in a 12-week, flexible-dose, open-label trial of citalopram. Primary outcome measure was the Clinical Global Impression Scale-Improvement, with responders defined by ratings of 1 (very much improved) or 2 (much improved). Secondary measures included self- and parent reports of abdominal pain, anxiety, depression, other somatic symptoms, and functional impairment. Side effects were assessed using a standardized checklist. Data were analyzed using an intent-to-treat format and the last observation carried forward procedure. RESULTS:Twenty-one subjects (84%) were classified as responders (Clinical Global Impression Scale-Improvement score < or =2). Citalopram was generally well tolerated. Four subjects withdrew prematurely, one due to reported visual side effects. Ratings of abdominal pain, anxiety, depression, other somatic symptoms, and functional impairment all improved significantly over the course of the study compared with baseline. CONCLUSIONS:Citalopram is a promising treatment for functional pediatric recurrent abdominal pain and deserves additional study with a randomized, placebo-controlled clinical trial.
journal_name
J Am Acad Child Adolesc Psychiatryauthors
Campo JV,Perel J,Lucas A,Bridge J,Ehmann M,Kalas C,Monk K,Axelson D,Birmaher B,Ryan N,Di Lorenzo C,Brent DAdoi
10.1097/01.chi.0000136563.31709.b0subject
Has Abstractpub_date
2004-10-01 00:00:00pages
1234-42issue
10eissn
0890-8567issn
1527-5418pii
S0890-8567(09)61577-Xjournal_volume
43pub_type
临床试验,杂志文章abstract:OBJECTIVE:This study examined associations between age of menarche and psychosocial outcomes in early adulthood, including sexual behavior, mental health, criminal behavior, and education/employment, to identify the possible causal role of earlier age of menarche in increasing risks of adverse outcomes. METHOD:Data we...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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doi:10.1097/01.chi.0000194568.70912.ee
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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更新日期:2010-08-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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doi:10.1016/j.jaac.2016.09.490
更新日期:2016-12-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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更新日期:2004-08-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-200101000-00021
更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00004583-199709000-00011
更新日期:1997-09-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
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更新日期:2005-08-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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更新日期:2011-10-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
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更新日期:2011-08-01 00:00:00