Genome-wide association study of the child behavior checklist dysregulation profile.

Abstract:

OBJECTIVE:A potentially useful tool for understanding the distribution and determinants of emotional dysregulation in children is a Child Behavior Checklist profile, comprising the Attention Problems, Anxious/Depressed, and Aggressive Behavior clinical subscales (CBCL-DP). The CBCL-DP indexes a heritable trait that increases susceptibility for later psychopathology, including severe mood problems and aggressive behavior. We have conducted a genome-wide association study of the CBCL-DP in children with attention-deficit/hyperactivity disorder (ADHD). METHOD:Families were ascertained at Massachusetts General Hospital and University of California, Los Angeles. Genotyping was conducted with the Illumina Human1M or Human1M-Duo BeadChip platforms. Genome-wide association analyses were conducted with the MQFAM multivariate extension of PLINK. RESULTS:CBCL data were available for 341 ADHD offspring from 339 ADHD affected trio families from the UCLA (N = 128) and the MGH (N = 213) sites. We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p < 5E-05: TMEM132D, LRRC7, SEMA3A, ALK, and STIP1. CONCLUSIONS:We found suggestive evidence for developmentally expressed genes operant in hippocampal dependent memory and learning with the CBCL-DP.

authors

Mick E,McGough J,Loo S,Doyle AE,Wozniak J,Wilens TE,Smalley S,McCracken J,Biederman J,Faraone SV

doi

10.1016/j.jaac.2011.05.001

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

807-17.e8

issue

8

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(11)00385-6

journal_volume

50

pub_type

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