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The persistence of high uptake of serum albumin in the olfactory bulbs of mice throughout their adult lives.

Abstract：

:Brain to plasma concentration ratios of i.v. administered human serum albumin (HSA) in the olfactory bulb, frontal cortex and cerebellum were evaluated in DDD mice of different ages. We measured the brain uptake of serum albumin excluding intravascular content by using a double isotope technique and examined the time course of the brain uptake to evaluate the brain uptake at different time intervals. In young adult mice, the value was significantly higher in the olfactory bulb than in other brain regions 3-24 h after (125)I-HSA injection. It was about 2.3 times higher in the olfactory bulb than in the cerebellum (P < 0.01). The high concentration ratios in the olfactory bulb were observed in all 4-22-month-old mice. Moreover, the ratio in the olfactory bulb 24 h after (125)I-HSA injection was higher in 22-month-old mice than in younger animals. The high uptake of serum albumin in the olfactory bulb suggests that intravascular macromolecules can be transported into the olfactory bulb more easily than in other brain regions with tight endothelium, and the persistence of high uptake during adult life may be associated with age-related morphological changes in the olfactory bulb.

journal_name

Arch Gerontol Geriatr

journal_title

Archives of gerontology and geriatrics

authors

Ueno M,Akiguchi I,Naiki H,Fujibayashi Y,Fukuyama H,Kimura J,Kameyama M,Takeda T

doi

10.1016/0167-4943(91)90062-u

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

201-9

issue

2

eissn

0167-4943

issn

1872-6976

pii

0167-4943(91)90062-U

journal_volume

13

pub_type

杂志文章

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