Expression of Alzheimer's amyloid precursor protein in human lymphocyte.

Abstract:

:Beta-amyloid precursor protein (betaAPP) has been shown to be involved in cell growth regulation. In spleen, the majority of cells showing betaAPP like immunoreactivity was found in the T cell-dependent zone. In Northern blot, the expression of betaAPP was increased to reach the peak at 72 h after the treatment of phytohemagglutinin (PHA). But, in cytofluorometry, almost all CD4(+) T helper/inducer cells and the majority of CD(8+) T suppressor/cytotoxic cells show betaAPP immunoreactivity which remained constant during the stimulation with PHA. These results suggest that betaAPP is a surface molecule of T lymphocyte and the turnover or release of APP might be increased with the treatment of T cell mitogen.

journal_name

Arch Gerontol Geriatr

authors

Suh YH,Choi W,Kim SH,Kim JS,Rhi BY,Chong YH,Woo JI,Lee KW

doi

10.1016/s0167-4943(96)00721-2

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

1-7

issue

1

eissn

0167-4943

issn

1872-6976

pii

S0167494396007212

journal_volume

24

pub_type

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