Abstract：
:The present study assesses the clinical usefulness of the hepatitis C core antigen assay for monitoring of patients being treated for chronic hepatitis C virus (HCV) infection. Eighty-six serum samples were selected at random from 16 patients and levels of HCV RNA and HCV core antigen were determined simultaneously and in parallel to compare both techniques. The data obtained were compared by Pearson's correlation and the coefficients calculated by Fisher transformation and by calculating the difference and standard error. A good linear correlation was observed between both techniques. Maximum correlation, with significant difference, was found between patients infected with the 1a genotype and other genotypes. In conclusion, the HCV core antigen assay is useful for the diagnosis of early infection; however, its use for determining the exact timing of viral elimination during treatment is clearly unsuitable.
journal_name
J Virol Methodsjournal_title
Journal of virological methodsauthors
Lorenzo J,Castro A,Aguilera A,Prieto E,López-Calvo S,Regueiro B,Pedreira Jdoi
10.1016/j.jviromet.2004.05.002subject
Has Abstractpub_date
2004-09-15 00:00:00pages
173-7issue
2eissn
0166-0934issn
1879-0984pii
S0166093404001466journal_volume
120pub_type
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