Abstract：
:This open-label, nonrandomized study compared changes in hemostatic variables during NuvaRing and oral levonorgestrel 150 microg/ethinylestradiol 30 microg (LNG/EE) use for six cycles. Eighty-seven women started the study, 44 with NuvaRing and 43 with the LNG/EE oral contraceptive. For most procoagulation variables, there was no difference between NuvaRing and oral LNG/EE; only Factor VII levels increased in the NuvaRing group and decreased in the LNG/EE group. The majority of assessed variables show that anticoagulation and fibrinolytic activity was comparable between the NuvaRing and oral LNG/EE groups. Antithrombin activity and protein C activity both tended to be higher with NuvaRing. Levels of tissue plasminogen activator decreased in both groups but the reduction was smaller with NuvaRing. There were no significant differences in fibrin turnover between the treatment groups. The data show that both NuvaRing and oral LNG/EE are associated with a minimal effect on hemostatic variables.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Magnusdóttir EM,Bjarnadóttir RI,Onundarson PT,Gudmundsdóttir BR,Geirsson RT,Magnusdóttir SD,Dieben TOdoi
10.1016/j.contraception.2003.12.010subject
Has Abstractpub_date
2004-06-01 00:00:00pages
461-7issue
6eissn
0010-7824issn
1879-0518pii
S0010782404000058journal_volume
69pub_type
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