Advances in molecular carcinogenesis: current and future use of mouse models to screen and validate molecularly targeted anticancer drugs.

abstract：:Oncoprotein p28(GANK), overexpressed in hepatocellular carcinomas (HCC), binds to RelA and retains NF-κB in the cytoplasm to suppress NF-κB transactivation. However, the mechanism has not yet been elucidated. In this study, we clarified the mechanism of NF-κB regulated by p28(GANK). p28(GANK) reduced TNF-α-induced nuc...

journal_title：Molecular carcinogenesis

authors： Ren YB,Luo T,Li J,Fu J,Wang Q,Cao GW,Chen Y,Wang HY

更新日期：2015-12-01 00:00:00

abstract：:RAD51D, a paralog of the mammalian RAD51 gene, contributes towards maintaining genomic integrity by homologous recombination DNA repair and telomere maintenance. A RAD51D variant, E233G, was initially identified as a potential susceptibility allele in high-risk, site-specific, familial breast cancer. We describe in th...

journal_title：Molecular carcinogenesis

authors： Nadkarni A,Rajesh P,Ruch RJ,Pittman DL

更新日期：2009-07-01 00:00:00

abstract：:Peptidylarginine deiminase type 4 (PAD4/PADI4) posttranslationally converts peptidylarginine to citrulline, in a process known as citrullination. Evidence suggests that PAD4 plays an essential role in pathogenesis of rheumatoid arthritis (RA). RA synovium has many features in common with tumor tissues, including abnor...

journal_title：Molecular carcinogenesis

authors： Chang X,Han J

更新日期：2006-03-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor family, induces apoptosis in a variety of cancer cells. However, gastric cancer (GC) cells are insensitive to TRAIL usually. In the previous study, we showed that Periplocin could induce apoptosis in GC cells via the...

journal_title：Molecular carcinogenesis

authors： Zhao LM,Li L,Huang Y,Han LJ,Li D,Huo BJ,Dai SL,Xu LY,Zhan Q,Shan BE

更新日期：2019-06-01 00:00:00

abstract：:The DNA repair gene Ku70 plays a key role in the DNA double strand break (DSB) repair system. Defects in DSB repair capacity can lead to genomic instability. We hypothesized that the Ku70 C-1310G polymorphism (rs2267437) was associated with risk of renal cell carcinoma (RCC). We genotyped the Ku70 C-1310G polymorphism...

journal_title：Molecular carcinogenesis

authors： Wang W,Pan X,Huo X,Yan F,Wang M,Wang D,Gao Y,Cao Q,Luo D,Qin C,Yin C,Zhang Z

更新日期：2012-10-01 00:00:00

abstract：:The expression of members of the family of matrix-degrading metalloproteinases (MMPs) is believed to contribute to the complex process of invasion and metastasis. In this study, specific cDNA probes for three members of the stromelysin subfamily of MMPs--stromelysin (MMP-3), stromelysin-2 (MMP-10), and pump-1 (MMP-7)-...

journal_title：Molecular carcinogenesis

authors： McDonnell S,Navre M,Coffey RJ Jr,Matrisian LM

更新日期：1991-01-01 00:00:00

abstract：:Several studies have shown that E-cadherin expression is lost during malignant transformation. We hypothesized that CpG methylation in the promoter region may inactivate the expression of the E-cadherin gene in human bladder cancer. Normal and bladder cancer samples from 51 patients were compared in terms of E-cadheri...

journal_title：Molecular carcinogenesis

authors： Ribeiro-Filho LA,Franks J,Sasaki M,Shiina H,Li LC,Nojima D,Arap S,Carroll P,Enokida H,Nakagawa M,Yonezawa S,Dahiya R

更新日期：2002-08-01 00:00:00

abstract：:An allelotype analysis of lung tumors in mouse hybrids was conducted to identify common regions of allelic loss. By using 50 informative genetic markers, the autosomes of 36 (A/J x C3H/HeJ) F1 adenocarcinomas were examined. Additional adenocarcinomas from as many as 72 (C3H/HeJ x A/J) F1 and 15 (BALB/cJ x DBA/2J) F1 h...

journal_title：Molecular carcinogenesis

authors： Herzog CR,Chen B,Wang Y,Schut HA,You M

更新日期：1996-06-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAPK) pathway is an important cell proliferation pathway. We previously reported that the transport protein particle complex 4 (TRAPPC4), ERK2 interaction may activate ERK1/2, modulate pERK2 nuclear localization and regulate proliferati...

journal_title：Molecular carcinogenesis

authors： Weng YR,Kong X,Yu YN,Wang YC,Hong J,Zhao SL,Fang JY

更新日期：2014-02-01 00:00:00

abstract：:Mutational activation of RAS proteins occurs in nearly 30% of all human tumors. To date direct pharmacological inhibition of RAS oncoproteins has not been possible. As a consequence, current strategies are focusing on the development of inhibitors that target those kinases acting downstream of RAS proteins, including ...

journal_title：Molecular carcinogenesis

authors： Urosevic J,Sum EY,Moneo V,Drosten M,Dhawahir A,Becerra M,Carnero A,Barbacid M

更新日期：2009-11-01 00:00:00

abstract：:We confirmed the expression of cathepsin K, the most abundant and specific cysteine protease found in osteoclasts, at the mRNA level in most of our cases of breast cancer, and even at the protein level in bone metastatic lesions. Therefore, we investigated the functions of cathepsin K in osteoclasts with special atten...

journal_title：Molecular carcinogenesis

authors： Ishikawa T,Kamiyama M,Tani-Ishii N,Suzuki H,Ichikawa Y,Hamaguchi Y,Momiyama N,Shimada H

更新日期：2001-10-01 00:00:00

abstract：:Aberrant microRNA (miRNA) expression is involved in tumorigenesis of several cancers, including non-small cell lung cancer (NSCLC). Furthermore, expression of some miRNAs has been shown to be under epigenetic regulation. However, less is known regarding the role of miRNA methylation in NSCLC development or clinical ou...

journal_title：Molecular carcinogenesis

authors： Tan W,Gu J,Huang M,Wu X,Hildebrandt MA

更新日期：2015-06-01 00:00:00

abstract：:C>T substitutions at dipyrimidine sites dominate the melanoma genome. We recently analyzed the exomes of spontaneous and neonatal UVR-induced murine melanomas, noting a dramatic change in the genomic footprint at C>T substitutions in the latter. Here we re-analyzed published exome-wide footprints in human melanomas st...

journal_title：Molecular carcinogenesis

authors： Mukhopadhyay P,Roberts JA,Walker GJ

更新日期：2017-06-01 00:00:00

abstract：:Microsatellite instability (MI) and loss of heterozygosity (LOH) were examined in mammary tumors induced in Sprague-Dawley x F344 F1 female rats by 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Examination of 62 microsatellite loci revealed MI in nine of 15 (60%) PhIP-induced mammary tumors, and five of thes...

journal_title：Molecular carcinogenesis

authors： Toyota M,Ushijima T,Weisburger JH,Hosoya Y,Canzian F,Rivenson A,Imai K,Sugimura T,Nagao M

更新日期：1996-03-01 00:00:00

abstract：:Cytogenetic and molecular studies of human renal cell carcinoma (RCC) have suggested that the genetic and functional losses of one or more putative tumor suppressor genes on the short arm of chromosome 3 play a crucial role in the development of this disease. To examine whether the introduction of chromosome 3 has any...

journal_title：Molecular carcinogenesis

authors： Yoshida MA,Shimizu M,Ikeuchi T,Tonomura A,Yokota J,Oshimura M

更新日期：1994-03-01 00:00:00

abstract：:Hepatitis B virus (HBV) X protein (HBx) and cyclooxygenase-2 (COX-2) are all playing roles in hepatocellular carcinoma (HCC), but the reversing effects of COX-2 inhibitors on the neoplastic features caused by HBx protein is still unclear. To further evaluate the therapeutic potential of celecoxib on HBx mediated trans...

journal_title：Molecular carcinogenesis

authors： Xie H,Gao L,Chai N,Song J,Wang J,Song Z,Chen C,Pan Y,Zhao L,Sun S,Wu K,Feitelson MA,Liu J,Fan D

更新日期：2009-01-01 00:00:00

abstract：:Base excision repair (BER) is critical for the maintenance of genome stability because it repairs at least 20,000 endogenously generated DNA lesions/cell/d. Several enzymes within the BER pathway exhibit sequence context dependency during the excision and DNA synthesis steps of repair. New evidence is emerging that ge...

journal_title：Molecular carcinogenesis

authors： Donigan KA,Sweasy JB

更新日期：2009-04-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a compound found in cooked meat, is a mammary gland carcinogen in female Sprague-Dawley rats. PhIP-induced rat mammary gland carcinomas were examined for mutations in several genes (exons) known to regulate cell growth and apoptosis, including p53 (4-8), p21(Waf1...

journal_title：Molecular carcinogenesis

authors： Yu M,Ryu DY,Snyderwine EG

更新日期：2000-02-01 00:00:00

abstract：:The Ki-ras proto-oncogene is activated by specific point mutations and is the transforming gene often identified in rodent and human lung tumors. An in vitro model to aid in the study of the consequences of Ki-ras activation and expression in mouse lung is needed. Accordingly, we have examined cell lines derived from ...

journal_title：Molecular carcinogenesis

authors： Pan YH,Nuzum EO,Hanson LA,Beer DG

更新日期：1990-01-01 00:00:00

abstract：:Increased epidermal growth factor receptor (EGFR) expression in triple-negative breast cancer (TNBC) is recognized as a promising therapeutic target, specifically through the use of selective EGFR inhibitors combined with chemotherapies. TNBC is characterized by genetic instability that leads to increased sensitivity ...

journal_title：Molecular carcinogenesis

authors： El Guerrab A,Bamdad M,Bignon YJ,Penault-Llorca F,Aubel C

更新日期：2017-05-01 00:00:00

abstract：:In this study, we found that rat nasal coumarin-7-hydroxylase (COH) activity was two orders of magnitude higher than rat hepatic COH activity and could be induced by adding coumarin to the rats' drinking water. In western blot analysis, an anti-cytochrome P450 (Cyp) 2a-5 (mouse liver COH) antibody recognized a sharp b...

journal_title：Molecular carcinogenesis

authors： Béréziat JC,Raffalli F,Schmezer P,Frei E,Geneste O,Lang MA

更新日期：1995-10-01 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive and highly invasive type of astrocytic tumors. Despite advances in diagnosis and therapy, the prognosis and survival time remain poor. Identifying key mediators of tumor cell proliferation, migration, and invasion is crucial to the development of new and more effective therapi...

journal_title：Molecular carcinogenesis

authors： Liu X,Gao Q,Zhao N,Zhang X,Cui W,Sun J,Fu J,Hao J

更新日期：2018-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a neoplasia representing the fifth most common malignancy worldwide and the third cause of death from cancer. Diets with high content in fruits and vegetables are widely recommended for their health-promoting properties, among them, the protection against diabetes, cancer, and cardiov...

journal_title：Molecular carcinogenesis

authors： Fernández-Bedmar Z,Anter J,Alonso-Moraga A,Martín de Las Mulas J,Millán-Ruiz Y,Guil-Luna S

更新日期：2017-06-01 00:00:00

abstract：:Liver tumors of certain strains of mice frequently contain mutations at codon 61 of the c-Ha-ras gene. In our study, we investigated the significance of these mutations in the carcinogenic process. Male C3H/He mice received a single injection of diethylnitrosamine (DEN) on day 15 after birth, and groups of animals wer...

journal_title：Molecular carcinogenesis

authors： Bauer-Hofmann R,Klimek F,Buchmann A,Müller O,Bannasch P,Schwarz M

更新日期：1992-01-01 00:00:00

abstract：:Breast cancer-associated mutations affecting the highly-conserved C-terminal BRCT domains of the tumor suppressor gene breast cancer susceptibility gene 1 (BRCA1) fully disrupt the ability of BRCA1 to interact with acetyl coenzyme A carboxylase alpha (ACCA), the rate-limiting enzyme catalyzing de novo fatty acid bioge...

journal_title：Molecular carcinogenesis

authors： Brunet J,Vazquez-Martin A,Colomer R,Graña-Suarez B,Martin-Castillo B,Menendez JA

更新日期：2008-02-01 00:00:00

abstract：:Rapid advances in multimodality therapy have not significantly improved the overall 5-yr survival of oral cancer patients in the past two decades, thereby underscoring the need for molecular therapeutics. The development of new treatment strategies for more effective management of oral cancer requires identification o...

journal_title：Molecular carcinogenesis

authors： Arora S,Matta A,Shukla NK,Deo SV,Ralhan R

更新日期：2005-02-01 00:00:00

abstract：:Angiogenesis is a prerequisite for progression of cancers. The number of genes linked to angiogenesis suggests the existence of complex gene-networks, which remain to be elucidated. To identify angiogenesis genes deregulated in carcinomas, we performed a meta-profiling analysis of published gene expression microarray ...

journal_title：Molecular carcinogenesis

authors： Anders M,Fehlker M,Wang Q,Wissmann C,Pilarsky C,Kemmner W,Höcker M

更新日期：2013-01-01 00:00:00

abstract：:It becomes feasible to perform genome-wide differential gene or protein expression in the post genome era. However, little has been addressed on the effects of external stresses and microenvironment alterations on the outcomes of gene and protein expression. To identify downregulated genes during hepatoma development,...

journal_title：Molecular carcinogenesis

authors： Hsieh SY,Chen WY,Shih TC,Yeh JY,Jeng JT

更新日期：2005-06-01 00:00:00

abstract：:Prostate cancer (PCa) patients' mortality is mainly attributed to complications caused by metastasis of the tumor cells to organs critical for survival, such as bone. We hypothesized that PCa cell-bone interactions would promote paracrine signaling. A panel of PCa cell lines were cocultured with hydroxyapatite ([HA]; ...

journal_title：Molecular carcinogenesis

authors： Henderson VM,Hawsawi O,Burton LJ,Campbell T,Trice K,Dougan J,Howard SM,Odero-Marah VA

更新日期：2019-08-01 00:00:00

abstract：:Male F(1) hybrids between MSM mice carrying a deficient p53 allele and BALB/c mice were irradiated with gamma-rays, and 80 thymic lymphomas were obtained, 46 of which developed in mice carrying the deficient p53 allele. Because the Y chromosome contributes little to cellular function, the stability of the Y chromosome...

journal_title：Molecular carcinogenesis

authors： Chou D,Matsuki J,Saitou Y,Kosugi SI,Shinbo T,Gejyo F,Niwa O,Kominami R

更新日期：1999-11-01 00:00:00