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Overexpression of DRG2 suppresses the growth of Jurkat T cells but does not induce apoptosis.

Abstract：

:Developmentally regulated GTP-binding protein (DRG) is a new subfamily within the superfamily of GTP-binding proteins. Its expression is regulated during embryonic development. To investigate the effect of the expression of DRG2 on cell growth, we constructed a human Jurkat-T-cell line that overexpresses DRG2. Overexpression of DRG2 suppressed the growth and the aggregation of Jurkat cells but did not induce apoptotic cell death. We used cDNA microarray analysis to examine the global changes in gene expression induced by an overexpression of DRG2. DNA array analyses identified genes that may suppress cell growth at a number of levels in multiple signaling cascades in Jurkat cells and also several prosurvival genes that may protect cells from apoptosis.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Ko MS,Lee UH,Kim SI,Kim HJ,Park JJ,Cha SJ,Kim SB,Song H,Chung DK,Han IS,Kwack K,Park JW

doi

10.1016/j.abb.2003.12.028

subject

Has Abstract

pub_date

2004-02-15 00:00:00

pages

137-44

issue

2

eissn

0003-9861

issn

1096-0384

pii

S0003986103007094

journal_volume

422

pub_type

杂志文章

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