Effect of nifedipine on the healing of left colonic anastomoses in rats.

Abstract:

PURPOSE:Ca(2+) channel blockers inhibit collagenase production and have a vasodilatatory effect. They also restrict the formation of ischemia-reperfusion induced free oxygen radicals. The aim of this study was to assess the effect of nifedipine on the healing of colonic anastomoses in a rat model. METHODS:Sixty Wistar rats weighing 240-290 g were divided into four groups of 15 rats each: a 3rd day control group (group A), a 3rd day treatment group (group B), a 7th day control group (group C), and a 7th day treatment group (group D). The treatment groups were given Nifedipine 3 mg/kg per day orally as three divided doses. RESULTS:The bursting pressure values of the anastomoses in the treatment groups were significantly higher than those in the control groups ( P < 0.05). The hydroxyproline content was also significantly higher in the treatment groups than in the control groups ( P < 0.05). Histologic examination confirmed that nifedipine treatment significantly increased collagen deposition and fibroblast ingrowth compared with controls ( P < 0.05). CONCLUSIONS:These results clearly showed that nifedipine enhanced the stability of colonic anastomoses during the first postoperative week.

journal_name

Surg Today

journal_title

Surgery today

authors

Ugurlu L,Turan M,Canbay E,Elagöz S,Sen M

doi

10.1007/s00595-003-2633-0

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

902-8

issue

12

eissn

0941-1291

issn

1436-2813

journal_volume

33

pub_type

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