Survival advantage of using autologous blood transfusion during surgery for esophageal cancer.

Abstract:

PURPOSE:There is evidence that blood transfusion is associated with an increased rate of tumor recurrence. This study was conducted to assess the survival advantage of giving autologous blood instead of allogeneic blood during surgery for esophageal cancer. METHODS:We retrospectively analyzed 62 patients who underwent esophagectomy for thoracic esophageal cancer between January 1991 and February 1995 and received allogeneic blood transfusion, and 61 patients operated on between March 1995 and February 1998, who received autologous blood transfusion. The clinicopathological factors and survival rates were compared between the two groups. RESULTS:The clinicopathological factors that influenced prognosis were similar in the two groups; however, a definite survival advantage was evident in the autologous blood transfusion group. According to multivariate analyses, the transfusion of allogeneic blood was an independent prognostic factor ( P = 0.0222), as was the presence of metastatic lymph nodes. Patients who received allogeneic blood transfusions perioperatively had more than a twofold greater risk (Hazard ration 2.406) of death over patients who received autologous blood transfusions. CONCLUSION:Autologous blood transfusion appears to be an independent prognostic factor for the survival of patients with esophageal cancer.

journal_name

Surg Today

journal_title

Surgery today

authors

Motoyama S,Saito R,Kamata S,Kitamura M,Okuyama M,Imano H,Nakamura M,Suzuki H,Omokawa S,Motohashi Y,Ogawa J

doi

10.1007/s005950200191

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

951-8

issue

11

eissn

0941-1291

issn

1436-2813

journal_volume

32

pub_type

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