Cilostazol suppresses neointimal hyperplasia in canine vein grafts.

Abstract:

PURPOSE:To investigate whether cilostazol, a cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitor, suppresses intimal hyperplasia in canine vein grafts, and to elucidate its mechanisms in terms of cell proliferation and apoptosis. METHODS:Bilateral reversed jugular vein interposition grafts of the common carotid artery were performed in 12 beagle dogs. Starting from 7 days before surgery, either cilostazol (30 mg/day; n = 6) or a placebo (n = 6) was given orally twice daily. Vein grafts were harvested at 1 or 4 weeks, and fixed under pressure for histological examination. RESULTS:By 1 week after implantation, the cilostazol group showed significantly less cell proliferation than the placebo group. By 4 weeks after implantation, intimal and medial thickness was significantly thinner in the cilostazol group than in the placebo group. There was significantly more apoptosis in the placebo group than in the cilostazol group at both time points. CONCLUSION:Cilostazol suppressed the development of intimal hyperplasia in canine autogenous vein grafts. Thus, it may be associated with the modulation of cell proliferation and apoptosis.

journal_name

Surg Today

journal_title

Surgery today

authors

Kudo FA,Kondo Y,Muto A,Miyazaki K,Dardik A,Nishibe M,Nishibe T

doi

10.1007/s00595-008-3819-2

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

128-32

issue

2

eissn

0941-1291

issn

1436-2813

journal_volume

39

pub_type

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