Abstract:
:Gastrointestinal stromal tumors (GISTs) rarely arise in the esophagus, where carcinoma is the most common malignant neoplasm and leiomyoma is the most common benign tumor. Because of their rarity, the clinical course and treatment of esophageal GISTs are poorly understood. These lesions are generally thought to carry a poor prognosis, making the differential diagnosis of other common mesenchymal neoplasms essential, for both prognostic and therapeutic reasons. We report a case of successfully resected giant esophageal GIST, thought to be the largest resected GIST reported in Japan. The patient was a 65-year-old woman, in whom upper gastrointestinal endoscopy found a 180-mm submucosal tumor in the lower thoracic esophagus, extending just below the aortic arch. We diagnosed esophageal GIST, and the patient underwent middle and lower esophagectomy via left thoracotomy, followed by gastric tube reconstruction. The tumor was resected completely. Histopathological and immunohistochemical staining confirmed that the tumor was a high-risk lesion, and treatment with imatinib was initiated. Computed tomography showed liver metastasis 5 months later, but the patient is doing well 24 months after surgery.
journal_name
Surg Todayjournal_title
Surgery todayauthors
Nakano A,Akutsu Y,Shuto K,Uesato M,Kono T,Hoshino I,Akanuma N,Maruyama T,Isozaki Y,Matsubara Hdoi
10.1007/s00595-014-0929-xsubject
Has Abstractpub_date
2015-02-01 00:00:00pages
247-52issue
2eissn
0941-1291issn
1436-2813journal_volume
45pub_type
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