Glucagon responses in rabbits with obstructive jaundice and a low energy status in the liver.

Abstract:

:Glucagon has a choleretic effect and also stimulates energy-consuming reactions, such as gluconeogenesis and ureogenesis in the liver. The effect of glucagon on energy metabolism in the liver was analyzed in rabbits with obstructive jaundice that had severe liver damage, indicated by significantly lower hepatic energy charge levels. The gluconeogenetic responses to glucagon administration, as shown by increases in the plasma glucose levels, were usually observed in normal rabbits, but these responses were completely depressed after glucagon administration in rabbits with obstructive jaundice. The energy charge levels in the latter animals decreased even further after glucagon administration. Even though the energy consumption for gluconeogenesis after glucagon administration was limited in the jaundiced rabbits, it was sufficient to cause a deterioration in the hepatic energy balance. The above findings show that the administration of glucagon increases the amount of energy expended in the liver following a reduction in the hepatic energy charge in rabbits with obstructive jaundice. Therefore, even though glucagon has a choleretic effect, it should be administered carefully to patients with obstructive jaundice, especially in those with severe liver damage, such as in patients with cholangitis.

journal_name

Surg Today

journal_title

Surgery today

authors

Fujii H,Yamamoto M,Mogaki M,Miura K,Itakura J,Okuda J,Matsumoto Y

doi

10.1007/BF02215811

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

982-6

issue

11

eissn

0941-1291

issn

1436-2813

journal_volume

24

pub_type

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