Abstract:
:Hepatic ischemia was induced by clamping the hepatic artery, portal vein, and bile duct. After 15 min of ischemia, the hepatic glutathione (GSH) content rapidly decreased. On the other hand, after the start of reperfusion, the hepatic GSH levels promptly increased and reached a peak at about 1 h, and thereafter decreased to a minimum level by 2 h. Under such conditions, we examined the changes in the methionine adenosyltransferase (MAT) activity in the liver. Though the time course of MAT activity was somewhat delayed compared with that of the hepatic GSH levels, both patterns were substantially similar during ischemia-reperfusion. In contrast to the changes in the MAT activity during ischemia-reperfusion, the levels of MAT protein were unchanged during these periods. When endogenous antioxidant coenzyme Q(10) (CoQ(10)) was administered to rats prior to ischemia, both the reduction in the MAT activity and hepatic GSH levels induced by ischemia-reperfusion were protected. Our findings suggest that CoQ(10) may posttranslationally regulate the MAT activity via the changes in the GSH level in the liver.
journal_name
Surg Todayjournal_title
Surgery todayauthors
Ito K,Miwa N,Hagiwara K,Yano T,Shimizu-Saito K,Goseki N,Iwai T,Horikawa Sdoi
10.1007/PL00010035subject
Has Abstractpub_date
1999-01-01 00:00:00pages
1053-8issue
10eissn
0941-1291issn
1436-2813pii
10.1007/PL00010035journal_volume
29pub_type
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