Cellular immunity to cartilage proteoglycans: relevance to the pathogenesis of ankylosing spondylitis.

abstract：:An attempt was made to ascertain whether intra-articular corticosteroids exert a harmful effect on primate cartilage. The knee joints of 10 Macaca irus monkeys were subjected to either one, two, or six injections of 20 mg methyl prednisolone or an equal number of control injections over a 12-week period. Minor degener...

journal_title：Annals of the rheumatic diseases

authors： Gibson T,Burry HC,Poswillo D,Glass J

更新日期：1977-02-01 00:00:00

abstract：:The effects of dietary fatty acid supplementation on various disease parameters in the spontaneously autoimmune MRL-mp-lpr/lpr mouse model of systemic lupus erythematosus before onset of disease were investigated. A fat deficient diet was supplemented with the following oils: olive oil, sunflower oil, evening primrose...

journal_title：Annals of the rheumatic diseases

authors： Godfrey DG,Stimson WH,Watson J,Belch JF,Sturrock RD

更新日期：1986-12-01 00:00:00

abstract：OBJECTIVE:To investigate quantitatively the mRNA expression levels of YKL-40, an established marker of rheumatoid and osteoarthritic cartilage degeneration in synovial fluid and serum, and a closely related molecule YKL-39, in articular chondrocytes. METHODS:cDNA array and online quantitative polymerase chain reaction...

journal_title：Annals of the rheumatic diseases

authors： Knorr T,Obermayr F,Bartnik E,Zien A,Aigner T

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVES:To evaluate the long-term efficacy and safety of canakinumab to treat patients with colchicine-resistant familial Mediterranean fever (crFMF) during Epoch 4 (weeks 41 to 113) of the CLUSTER study. METHODS:Patients received open-label canakinumab 150 or 300 mg, every 4 or 8 weeks during a 72-week period. We ...

journal_title：Annals of the rheumatic diseases

authors： Ozen S,Ben-Cherit E,Foeldvari I,Amarilyo G,Ozdogan H,Vanderschueren S,Marzan K,Kahlenberg JM,Dekker E,De Benedetti F,Koné-Paut I

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Chronic systemic inflammation may contribute to accelerated atherosclerosis and increased arterial stiffness in patients with rheumatoid arthritis (RA). In addition to lowering cholesterol, statins have immunomodulatory effects which may be especially beneficial in patients with RA who have systemic immune a...

journal_title：Annals of the rheumatic diseases

authors： Van Doornum S,McColl G,Wicks IP

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:To investigate the sympathetic and parasympathetic cardiovascular function in primary Sjögren's syndrome (SS) and to investigate the possible relation with ocular dryness. METHODS:41 (40 women) patients with primary SS, mean age 50 years (range 20-80) with a mean disease duration of eight years (range 1-30),...

journal_title：Annals of the rheumatic diseases

authors： Barendregt PJ,van Den Meiracker AH,Markusse HM,Tulen JH,Boomsma F,van Der Heijde GL,Veld AJ

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVES:To elucidate the contribution of HLA-DR-DQ haplotypes and their genotypic combinations to susceptibility to rheumatoid arthritis, and to evaluate the various models for HLA associated risk for the disease in a series of Finnish patients. METHODS:322 Finnish patients with rheumatoid arthritis were typed for ...

journal_title：Annals of the rheumatic diseases

authors： Laivoranta-Nyman S,Möttönen T,Hermann R,Tuokko J,Luukkainen R,Hakala M,Hannonen P,Korpela M,Yli-Kerttula U,Toivanen A,Ilonen J,FIN-RACo Trial Group.

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVES:To compare the prevalence and pattern of neuropsychiatric (NP) syndromes observed in systemic lupus erythematosus (SLE) to patients with Primary Sjögren syndrome (PSS) using the American College of Rheumatology (ACR) criteria for the 19 NP syndromes seen in SLE. METHODS:A population-based study was conducte...

journal_title：Annals of the rheumatic diseases

authors： Harboe E,Tjensvoll AB,Maroni S,Gøransson LG,Greve OJ,Beyer MK,Herigstad A,Kvaløy JT,Omdal R

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Several studies suggest a role of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in the pathophysiology of primary osteoarthritis (OA). A common polymorphism of the GH receptor (exon 3 deletion, d3-GHR) is associated with increased GH/IGF-1 activity. OBJECTIVE:To study associations betwee...

journal_title：Annals of the rheumatic diseases

authors： Claessen KM,Kloppenburg M,Kroon HM,Bijsterbosch J,Pereira AM,Romijn JA,van der Straaten T,Nelissen RG,Hofman A,Uitterlinden AG,Duijnisveld BJ,Lakenberg N,Beekman M,van Meurs JB,Slagboom PE,Biermasz NR,Meulenbelt I

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:To study the ability of technetium-99m hexamethyl propylene amineoxime (HMPAO) labelled lymphocyte scintigraphy to quantify synovial inflammation, and to analyse the kinetics of lymphocyte retention in the joints of patients with rheumatoid arthritis (RA). METHODS:After isolation of the lymphocytes, the cel...

journal_title：Annals of the rheumatic diseases

authors： Jorgensen C,Couret I,Bologna C,Rossi M,Sany J

更新日期：1995-01-01 00:00:00

abstract：:Of 29 524 hospitalised medical patients monitored in a drug surveillance programme 1835 (6.2%) received the xanthine oxidase inhibitor allopurinol. After the exclusion of skin reactions adverse effects were attributed to this drug in 33 (1.8%) patients, the most frequent being haematological abnormalities (11 patients...

journal_title：Annals of the rheumatic diseases

authors： McInnes GT,Lawson DH,Jick H

更新日期：1981-06-01 00:00:00

abstract：OBJECTIVES:To review systematically the available literature on the optimal dosage and route of administration of methotrexate in patients with rheumatoid arthritis (RA), as an evidence base for generating clinical practice recommendations. METHODS:A systematic literature search was carried out in MEDLINE, EMBASE, Coc...

journal_title：Annals of the rheumatic diseases

authors： Visser K,van der Heijde D

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To score systemic activity at diagnosis and correlate baseline activity with survival in a large cohort of patients with primary Sjögren syndrome (SS). PATIENTS AND METHODS:We include 1045 consecutive patients who fulfilled the 2002 classification criteria for primary SS. The clinical and immunological chara...

journal_title：Annals of the rheumatic diseases

authors： Brito-Zerón P,Kostov B,Solans R,Fraile G,Suárez-Cuervo C,Casanovas A,Rascón FJ,Qanneta R,Pérez-Alvarez R,Ripoll M,Akasbi M,Pinilla B,Bosch JA,Nava-Mateos J,Díaz-López B,Morera-Morales ML,Gheitasi H,Retamozo S,Ramos-Ca

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVES:The objectives of this study were to determine whether late apoptotic cell material directly induces autoantibodies characteristic of systemic lupus erythematosus (SLE) and to investigate the innate recognition pathways involved. METHODS:B6, B6.MyD88(-/-), B6.TLR7(-/-) and B6.TLR9(-/-) mice were subcutaneou...

journal_title：Annals of the rheumatic diseases

authors： Pan ZJ,Maier S,Schwarz K,Azbill J,Akira S,Uematsu S,Farris AD

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:To report the results of a pilot study using rituximab combined with Peg-interferon (IFN) alpha2b-ribavirin in severe refractory hepatitis C virus (HCV) related mixed cryoglobulinaemia (MC) vasculitis. METHODS:Sixteen consecutive patients with severe HCV-MC vasculitis that were resistant (n = 11) or relapse...

journal_title：Annals of the rheumatic diseases

authors： Saadoun D,Resche-Rigon M,Sene D,Perard L,Karras A,Cacoub P

更新日期：2008-10-01 00:00:00

abstract：:A 17-year-old female patient with systemic lupus erythematosus (SLE) developed chronic tophaceous gout, chondrocalcinosis and articular capsule calcification in several joints. Analysis of synovial fluid and tophi revealed the coexistence of monosodium urate, calcium pyrophosphate, hydroxyapatite, and cholesterol crys...

journal_title：Annals of the rheumatic diseases

authors： Rodríguez MA,Paul H,Abadí I,Bravo JR,Armas P

更新日期：1984-06-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that pustulosis palmaris et plantaris and psoriatic arthritis (PsA) are two distinct diseases, and that the associated dermatoses are therefore also distinct diseases. METHODS:We prospectively performed clinical, radiological, biological, and bone scan investigations in 23 outpatients ...

journal_title：Annals of the rheumatic diseases

authors： Mejjad O,Daragon A,Louvel JP,Da Silva LF,Thomine E,Lauret P,Le Loët X

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVES:To investigate the association of lifestyle factors with risk of inflammatory polyarthritis (IP) and rheumatoid arthritis (RA). METHODS:The European Prospective Investigation of Cancer, Norfolk, UK (EPIC-Norfolk) gathered lifestyle data from participants aged 40-79 years from 1993 to 1997. Individuals who s...

journal_title：Annals of the rheumatic diseases

authors： Lahiri M,Luben RN,Morgan C,Bunn DK,Marshall T,Lunt M,Verstappen SM,Symmons DP,Khaw KT,Wareham N,Bruce IN

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the risk of psoriatic arthritis (PsA) among patients with psoriasis exposed to physical trauma. METHODS:A matched cohort study was performed using data from The Health Improvement Network (THIN). Patients with psoriasis exposed to trauma were randomly matched to up to five unexposed psoriasis co...

journal_title：Annals of the rheumatic diseases

authors： Thorarensen SM,Lu N,Ogdie A,Gelfand JM,Choi HK,Love TJ

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the contribution of polymorphisms in the vitamin D receptor (VDR) gene to ethnic variations in bone mass in mother and children from different ethnic origins. METHODS:VDR genotypes and bone mass in 43 African-American and white women, mean age 38.2 years, and 41 of their children were studied. Al...

journal_title：Annals of the rheumatic diseases

authors： Nelson DA,Vande Vord PJ,Wooley PH

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVES:The recombinant zoster vaccine (RZV) containing a strong non-aluminium adjuvant is associated with increased risk of gout flares, presumably via NLRP3 inflammasome activation. We tested the possibility that other vaccines may also be associated with gout flares. METHODS:We conducted an online case-crossover...

journal_title：Annals of the rheumatic diseases

authors： Yokose C,McCormick N,Chen C,Neogi T,Chaisson C,Terkeltaub R,Hunter DJ,Zhang Y,Choi H

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:To determine the incremental cost-effectiveness ratios (ICERs) of two therapeutic regimens of infliximab for ankylosing spondylitis (AS). METHODS:230 patients with active AS who were participating in a randomised controlled trial comparing two infliximab infusion modalities-every 6 weeks (Q6) and on demand (...

journal_title：Annals of the rheumatic diseases

authors： Fautrel B,Benhamou M,Breban M,Roy C,Lenoir C,Trape G,Baleydier A,Ravaud P,Dougados M

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To determine if early MRI measures predict X-ray progression at 1 and 2 years in a large RA trial cohort. DESIGN:This study included 256 methotrexate (MTX)-naïve RA patients from a randomised placebo-controlled trial of golimumab (GO-BEFORE). MRIs of wrist and 2nd-5th metacarpophalangeal joints at 0, 12, 24,...

journal_title：Annals of the rheumatic diseases

authors： Baker JF,Ostergaard M,Emery P,Hsia EC,Lu J,Baker DG,Conaghan PG

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:To investigate whether bortezomib, a proteasome inhibitor approved for treatment of multiple myeloma, induces clinically relevant plasma cell (PC) depletion in patients with active, refractory systemic lupus erythematosus (SLE). METHODS:Twelve patients received a median of two (range 1-4) 21-day cycles of i...

journal_title：Annals of the rheumatic diseases

authors： Alexander T,Sarfert R,Klotsche J,Kühl AA,Rubbert-Roth A,Lorenz HM,Rech J,Hoyer BF,Cheng Q,Waka A,Taddeo A,Wiesener M,Schett G,Burmester GR,Radbruch A,Hiepe F,Voll RE

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:The impact of immunosuppression on postoperative outcomes has primarily been studied in patients undergoing joint replacement surgery. We aimed to evaluate the impact of biologics and glucocorticoids on outcomes after other major surgeries. METHODS:This retrospective cohort study used Medicare data 2006-201...

journal_title：Annals of the rheumatic diseases

authors： George MD,Baker JF,Winthrop KL,Goldstein SD,Alemao E,Chen L,Wu Q,Xie F,Curtis JR

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:C-C chemokine receptor type 5 (CCR5), a chemokine receptor expressed on T cells and macrophages, and its ligands are found in inflamed synovial tissue (ST) of patients with rheumatoid arthritis (RA). The rationale for testing CCR5 blockade in patients with RA was supported by the effects of a CCR5 antagonist ...

journal_title：Annals of the rheumatic diseases

authors： van Kuijk AW,Vergunst CE,Gerlag DM,Bresnihan B,Gomez-Reino JJ,Rouzier R,Verschueren PC,van der Leij C,Maas M,Kraan MC,Tak PP

更新日期：2010-11-01 00:00:00

abstract：:To identify the local factors in cartilage that are responsible for the induction of pannus invasion, a 14 day organ culture study in which rheumatoid synovium was grown in contact with cartilage pieces was carried out. Rheumatoid synovium preferentially extended over hyaluronidase treated cartilage pieces, but detach...

journal_title：Annals of the rheumatic diseases

authors： Shiozawa S,Yoshihara R,Kuroki Y,Fujita T,Shiozawa K,Imura S

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:No consistent relationship between the severity of symptoms of knee osteoarthritis (OA) and radiographic change has been demonstrated. OBJECTIVES:To determine the relationship between symptoms of knee OA and tibial cartilage volume, whether pain predicts loss of cartilage in knee OA, and whether change in c...

journal_title：Annals of the rheumatic diseases

authors： Wluka AE,Wolfe R,Stuckey S,Cicuttini FM

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVES:We assessed the impact of tocilizumab (TCZ), a humanised monoclonal anti-interleukin-6 receptor antibody, on antibody response following administration of the 23-valent pneumococcal polysaccharide vaccine (PPV23). METHODS:A total of 190 patients with rheumatoid arthritis (RA) received PPV23. Patients were c...

journal_title：Annals of the rheumatic diseases

authors： Mori S,Ueki Y,Akeda Y,Hirakata N,Oribe M,Shiohira Y,Hidaka T,Oishi K

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:To investigate the involvement of interleukin-1 (IL-1) in the induction or maintenance of the insulin-like growth factor 1 (IGF-1) non-responsive state of chondrocytes during experimental arthritis in mouse knee joints. METHODS:To characterise IGF-1 nonresponsiveness during arthritis, we measured chondrocyte...

journal_title：Annals of the rheumatic diseases

authors： Verschure PJ,Joosten LA,Van de Loo FA,Van den Berg WB

更新日期：1995-12-01 00:00:00