Abstract:
:The treatment of peritonitis in continuous ambulatory peritoneal dialysis patients is empiric until the bacteriological results are available. The Lymulus amebocyte lysate assay (LAL) is a very sensitive method for the detection of endotoxin, a structural component of gram-negative bacteria. We performed the LAL assay in a prospective study in 36 consecutive episodes of peritonitis. The LAL assay was positive in all 10 episodes of gram-negative peritonitis (100% specificity). Treatment directed specifically against gram-negative or -positive infection was started based on the LAL assay result. In 26 episodes with LAL-negative test, a gram-positive bacterium was cultured in 23 episodes, in 1 there was fungal infection and 2 were sterile. In summary: the LAL assay is a rapid (1 h) and sensitive method for the differentiation of gram-positive or -negative peritonitis and enables starting an immediate and more appropriate antibiotic therapy.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Peer G,Serban I,Blum M,Cabili S,Iaina Adoi
10.1159/000168412subject
Has Abstractpub_date
1992-01-01 00:00:00pages
19-21issue
1-2eissn
0250-8095issn
1421-9670journal_volume
12pub_type
杂志文章abstract:BACKGROUND:To evaluate the association of dialysate interleukin-6 (IL-6), a marker of ongoing peritoneal inflammation, with the alteration of peritoneal solute transport rate (PSTR) in continuous ambulatory peritoneal dialysis (CAPD) patients. METHODS:Stable CAPD patients were enrolled in the present study. A total of...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000362622
更新日期:2014-01-01 00:00:00
abstract::Proteinuria is characteristic of many glomerular conditions, and often exceeds 2-3 g/24 h. There are several possible routes by which such profuse proteinuria might contribute to progression of the underlying pathology, whatever its type. First, proteinuria leads to a transit of protein through glomerular structures, ...
journal_title:American journal of nephrology
pub_type: 杂志文章,评审
doi:10.1159/000168199
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND/AIMS:The susceptibility of patients on maintenance hemodialysis (MHD) to infections is a major cause of mortality and morbidity. Natural resistance-associated macrophage protein 1 (Nramp1) regulates intracellular pathogen proliferation, and its mRNA expression is highest in polymorphonuclear leukocytes (PMNL...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000337742
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:Post-renal transplant recurrent glomerulonephritis (GN) contributes to allograft loss. Rituximab treatment has been used in a multidose strategy with variable efficacy and toxicity. We investigated a novel single-dose approach. METHODS:A single center, retrospective, cohort study was conducted between ...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000371587
更新日期:2015-01-01 00:00:00
abstract::Ultramorphological images and details of an uremic echinocyte are shown. The images confirm the existence of uremic echinocytes and demonstrate that atomic force microscopy can provide high-resolution images of cell surfaces. ...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000168714
更新日期:1994-01-01 00:00:00
abstract::Several medical inventors in Europe and North America brought the artificial kidney (hemodialysis) to practical usefulness in the late 1940s, but there were very few early successes. It was used at first for only desperate cases of acute renal failure. Renal authorities in the 'metabolic' tradition favored newly quant...
journal_title:American journal of nephrology
pub_type: 历史文章,杂志文章
doi:10.1159/000169117
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND/AIMS:Cystic epithelia in polycystic kidney disease display features similar to malignant cells. Thiazolidinediones have been shown to have anti-neoplastic properties, therefore we tested the hypothesis that pioglitazone reduces cyst formation, improves renal function, and prolongs survival in a mouse model o...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000242432
更新日期:2009-01-01 00:00:00
abstract::A patient with unilateral gross hematuria was found to have mesangial proliferation and IgM deposition on renal biopsy, consistent with the entity of primary renal hematuria. This case refutes previous assumptions that renal biopsy is normal in patients with unilateral hematuria. Glomerular lesions may be more common ...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000167127
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND/AIMS:Although annual influenza vaccination is recommended for kidney transplant recipients, efficacy as reflected by serum antibody titers has not been well studied beyond 1 month in kidney transplant recipients. METHODS:We performed a single-center prospective cohort study of 51 kidney transplant recipient...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000341653
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Tacrolimus has been reported to be effective in refractory nephrotic syndrome, such as focal segmental glomerulosclerosis and membranous nephropathy. Some IgA nephropathy (IgAN) patients with massive proteinuria showed resistance to steroids and/or cytotoxic immunosuppressants based on the supportive therapy...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000337175
更新日期:2012-01-01 00:00:00
abstract::Bardoxolone methyl has been reported to cause detrimental cardiovascular events in the terminated BEACON Phase III human clinical trial via modulation of the renal endothelin pathway. However, the effects of bardoxolone methyl administration on the endothelin pathway in the heart are unknown. Our purpose in this persp...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000368563
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Serum protein profiling patterns can reflect the pathological state of a patient and therefore may be useful for clinical diagnostics. Here, we present results from a pilot study of proteomic expression patterns in hemodialysis patients designed to evaluate the range of serum proteomic alterations in this po...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000077409
更新日期:2004-03-01 00:00:00
abstract::Renal function and life expectancy can be improved by aggressive antihypertensive therapy in severe hypertension. However, most reports of severe hypertension and renal failure concern primary hypertensive states. 3 cases of primary renal disease, 1 glomerular, 1 obstructive and 1 of chronic pyelonephritis, are descri...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000166576
更新日期:1982-01-01 00:00:00
abstract::Forty-eight chronic hemodialysis patients were divided comparably into two groups (24 patients in each). Two micrograms of 1 alpha(OH)D3 was administered to one group for 3 months and its placebo to the other group. In the 1 alpha(OH)D3-treated group, serum total calcium increased from 7.82 +/- 0.11 (mean +/- SEM) to ...
journal_title:American journal of nephrology
pub_type: 临床试验,杂志文章
doi:10.1159/000167658
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Tacrolimus is mainly metabolized by cytochrome P450 3A5 (CYP3A5), which is expressed in the liver. However, CYP3A5 is also expressed in the kidney tissue and may contribute to local tacrolimus clearance in the kidney allograft. We aimed to evaluate the association between the allograft CYP3A5 genotype and tr...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000487857
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:Intravenous (IV) iron preparations are widely used in the management of anemia in ESRD populations. Recent changes in reimbursement policy have dramatically increased the use of IV iron to lower the use of costly erythropoiesis-stimulating agents. These preparations are frequently administered with insu...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000334939
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:In autosomal dominant polycystic kidney disease, renoprotective treatment with a vasopressin V2 receptor antagonist (V2RA) is given in a fixed dose (FD). Disease progression and drug habituation could diminish treatment efficacy. We investigated whether the renoprotective effect of the V2RA can be improved b...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000448693
更新日期:2016-01-01 00:00:00
abstract::Awareness that sphygmomanometry is encompassed with serious limitations has led to the development of techniques that allow blood pressure (BP) to be monitored intraarterially or noninvasively during the day or over a 24-hour period. Although intraarterial BP monitoring allows an accurate evaluation of 24-hour BP mean...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000167335
更新日期:1986-01-01 00:00:00
abstract::The effects of cisplatin (5 mg/kg BW given intraperitoneally) on renal concentration mechanism were evaluated initially by clearance studies in rats 5-7 days after cisplatin administration and compared to normal rats. During hypotonic saline infusion, cisplatin rats showed a lower inulin clearance (0.56 +/- 0.07 vs. 1...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000167938
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Aldosterone plays an important role in fibrosis. Recent studies showed that Na(+)-H(+) exchanger isoform 1 (NHE1) is involved in mineralocorticoid-induced organ fibrosis. In this study, we examined the role of NHE1 in aldosterone-induced fibronectin accumulation in rat mesangial cells and the signaling pathw...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000256665
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND/AIMS:We previously reported that patients with chronic kidney disease (CKD) receiving warfarin therapy and whose international normalized ratio increases to >3.0 may develop acute kidney injury (AKI) as a result of glomerular hemorrhage and formation of obstructive red blood cell (RBC) casts. We named this c...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000337918
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Malnutrition-inflammation score (MIS) is a comprehensive and quantitative system to assess malnutrition-inflammation complex syndrome, and a strong correlation between MIS and morbidity/mortality in maintenance hemodialysis (MHD) patients had been demonstrated. However, there is no cut-off value of MIS to ca...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000137684
更新日期:2008-01-01 00:00:00
abstract::The use of Dacron cuff double-lumen permanent catheters for hemodialysis has become more common in the dialysis unit as patients await for creation or maturation of a permanent hemoaccess for various reasons. Placement of these catheters is often done by surgeons. Nephrologists skilled in the placement of temporary ce...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000013425
更新日期:1999-01-01 00:00:00
abstract::Whole plasma from 6 normolipidemic chronic renal failure (CRF) patients undergoing hemodialysis treatment was passed through the anti-apolipoprotein (Apo) AI immunosorbent column connected to the anti-Apo B immunoaffinity column. Apo AI and B containing particles were analyzed for lipid and Apo contents. The results w...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000169011
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:The prognostic value of the anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (GN) classification has been demonstrated in several cohorts with sclerotic class having the worst renal outcome. Relevant published data on factors predicting outcomes in sclerotic ANCA GN is limited. METH...
journal_title:American journal of nephrology
pub_type: 杂志文章,多中心研究
doi:10.1159/000494840
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Oxidative stress and inflammation are known to play central roles in the development of diabetic nephropathy (DN). Febuxostat is a novel non-purine xanthine oxidase (XO)-specific inhibitor developed to treat hyperuricemia. In this study, we investigated whether febuxostat could ameliorate DN via renoprotecti...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000363421
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIM:Nephropathy after ingestion of Chinese herbs is known as a rapidly progressive form of interstitial renal fibrosis after a slimming regimen containing aristolochic acid that was identified first in Belgium. Intake of traditional Chinese herbal medicines is very popular in Taiwan. So we looked for similar...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000046647
更新日期:2001-11-01 00:00:00
abstract::Pasteurella multocida has been reported only once previously as a cause of peritonitis in a patient undergoing chronic peritoneal dialysis. The present report describes findings associated with a case of P. multocida peritonitis in a human immunodeficiency virus (HIV)-positive patient in which renal replacement therap...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000168274
更新日期:1991-01-01 00:00:00
abstract::A patient with advanced chronic renal failure secondary to polycystic kidney disease suffered an episode of volume contraction during which his urinary sodium concentration fell to less than 5 mEq daily. Urine sodium excretion remained at this level when later in his course he became clinically volume expanded. The pa...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000166535
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:End-stage renal disease (ESRD) is a disease with an aging population and a high prevalence of cognitive impairment affecting quality of life, health care costs and mortality. Structural changes in the brain with decreased white matter integrity have been observed in ESRD. Understanding the changes in cogniti...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000444334
更新日期:2016-01-01 00:00:00