Allo-immunization during pregnancy. Clinical results from 1983 to 1989 in a Scandinavian university hospital.

Abstract:

:From 1983 to 1989, 147,068 pregnancies were analyzed for allo-immunization against erythrocyte antigens. Approximately half of the cases were due to immunization against factor D and the others were due to allo-immunization against other antigens (K, c, E, etc.). In 61 cases exchange transfusion of the newborn was needed and in 115 cases diagnostic amniocentesis was done during pregnancy. Intrauterine transfusions were performed in 10 cases. Fetal and neonatal mortality was 4% in these moderate to severe cases, all due to immunization against D. Immunization against D was due to failure to give immunoglobulin anti-D in about 2/3 of the cases. Systematic prophylactic treatment with anti-D during pregnancy would probably not be cost-effective in this population.

authors

Belfrage P,Thomassen P,Floberg J,Akerblom O,Broberger U

doi

10.3109/00016349209021051

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

273-7

issue

4

eissn

0001-6349

issn

1600-0412

journal_volume

71

pub_type

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