Abstract:
:Our purpose was to investigate whether obstetric analgesia, particularly by nitrous oxide, constitutes a risk that the infant might develop amphetamine addiction in later life. Of 200 current amphetamine addicts born between 1945 and 1966 in Stockholm, proportionately more were born at hospitals where pain medication had been administered in large doses (p less than 0.05). A blind matched comparison was made between 73 addicts and 109 non-addicted siblings by logistic regression, in which nitrous oxide administration was tested in competition with 12 other natal variables as possible confounders. The risk for amphetamine drug addiction in offspring was found to increase with duration of intermittent administration of pure nitrous oxide, i.e. it was estimated to be 5.6 times greater (95% confidence intervals 1.6-16.9, p = 0.005) when nitrous oxide had been given for greater than or equal to 4.5 h vis-à-vis less than or equal to 0.25 h. Calculated risks are probably underestimates. Results can be explained as an effect of imprinting. It is concluded that local or regional anesthesia are preferable to general anesthesia which allows substantial amounts of drugs to cross the placenta.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
Jacobson B,Nyberg K,Eklund G,Bygdeman M,Rydberg Udoi
10.3109/00016349809004288subject
Has Abstractpub_date
1988-01-01 00:00:00pages
677-82issue
8eissn
0001-6349issn
1600-0412journal_volume
67pub_type
杂志文章abstract:OBJECTIVE:To study to what extent the fetal scalp blood lactate concentration during labor correlates with fetal scalp pH and base deficit, and metabolic acidosis at birth, and to suggest lactate cut-off values to serve as indicators for either reassurance or immediate intervention. DESIGN:A retrospective observationa...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.2011.01237.x
更新日期:2011-10-01 00:00:00
abstract::First catch urine (FCU) from 751 asymptomatic adolescent female high school students, with sexual debut, were screened for the presence of Chlamydia trachomatis (Group A). The prevalence of C. trachomatis infection in Group A was 2.1% (16/751). In Group B, 619 asymptomatic adolescent females attending a youth and a fa...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349409013397
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:To determine the influence of hyaluronan and its receptor CD44 in the angiogenesis and invasiveness of intravenous leiomyomatosis (IVL). METHODS:Paraffin-embedded sections from four IVL cases and 10 uterine leiomyoma cases were immunohistochemically stained for CD34, CD44, basic fibroblast growth factor (bF...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2005.00707.x
更新日期:2005-04-01 00:00:00
abstract::A case of an ovarian carcinoma presenting as a primary cervical carcinoma is described. Although a rare event, this must be considered whenever the clinical or histological findings are unusual. The importance of careful histological review of all specimens in cases such as this is emphasized. ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349009028691
更新日期:1990-01-01 00:00:00
abstract::The experience using pre-treatment with GnRH-agonists in an IVF-program are reported. 55 patients having a 'poor response', premature LH surge, or follicular luteinization in previous treatment cycles were treated for a total of 68 cycles. Therapy with GnRH agonists was initiated in the midluteal phase, and given by s...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349109007884
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:To investigate the ability of bacterial lipopolysaccharide delivered by the intra-uterine route to cause uterine contractions in rabbits, and to assess the suppressive effect of urinary trypsin inhibitor on them. METHODS:Both pregnant and non-pregnant rabbits were chronically implanted with a force-transduc...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349709047780
更新日期:1997-01-01 00:00:00
abstract::Two hyperprolactinemic infertile women, one with and one without a pituitary adenoma, who were resistant to bromocriptine treatment, were treated orally with Hachimijiogan, a Chinese herbal medicine. This treatment reduced the serum prolactin level, resulting in a normal ovulatory cycle and pregnancy, without side eff...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348909021028
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Estrogen and progesterone immunoregulate the genital environment by expression of cytokines and growth factors. OBJECTIVE:To investigate the pattern of expression of T-helper cytokines during the ovarian cycle compared with women with chronic anovulation resistant to clomiphene citrate. HYPOTHESIS:Expressi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2003.00045.x
更新日期:2003-07-01 00:00:00
abstract::Eighty-two gynecological patients with clinical signs of a lower urinary tract infection (UTI) were randomized to 10 days' treatment with either a fixed combination of pivampicillin-pivmecillinam (PAPM) or trimethoprim-sulphamethoxazole (TMPS). The effect of treatment could be evaluated in 25 patients on PAPM and in 1...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016348309154228
更新日期:1983-01-01 00:00:00
abstract::29 female immunosuppressed renal transplant recipients were examined gynecologically. In 2 cases the epithelium of the portio was found to be dysplastic, while endometrial carcinoma was present in 1 patient. A review of the literature suggests that immunosuppressed patients are more likely to develop tumors than other...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347809154202
更新日期:1978-01-01 00:00:00
abstract::The purpose of the present study was to establish the occurrence of infertility in Finnish women aged 30, 35 and 40 years. The study is based on an interview by questionnaire carried out on women participating in screening for cancer by Pap smear. The participation rate is generally about 60%. A total of 4,879 women w...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348609157030
更新日期:1986-01-01 00:00:00
abstract::Strips of ovarian hilar tissue taken from 11 post-menopausal women were examined histologically and found to contain clusters of hilus cells in contiguity with non-myelinated nerve fibers. No other steroidogenically active structures were found. Specimens from these strips were incubated for 30 and 240 minutes in Kreb...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348209156582
更新日期:1982-01-01 00:00:00
abstract::A study was planned to evaluate the effect of Prostaglandin E2 pessaries in three different dosages in ripening the unfavourable cervix prior to the induction of labor. A single dose of PGE2 as pessary in the three different dosages was administered into the posterior vaginal fornix to ripen an unfavourable cervix wit...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.3109/00016348409156268
更新日期:1984-01-01 00:00:00
abstract::In a series of 43 healthy women menstrual blood loss was determined before and after insertion of copper IUD (Gravigard). The menstrual blood loss before insertion was compared with the blood loss 1, 2, 3, 4, 5, 6, 7 and 12 months after insertion. An increase amounting to approximately 20 ml per period without signifi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347509156760
更新日期:1975-01-01 00:00:00
abstract:INTRODUCTION:Balanced information before prenatal diagnosis (PND) aims to help expectant parents to make an informed choice. However, it is important that the information does not increase the expectant parents' psychological distress. The aim was to examine psychological distress among expectant parents, before and af...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13195
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVES:to evaluate the additional information of second trimester magnetic resonance imaging (MRI) compared to ultrasound in fetuses with identified or suspected central nervous system (CNS) anomalies and to study the clinical impact of the information on pregnancy management. DESIGN:prospective study during 2004-...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349.2010.526184
更新日期:2010-12-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to investigate the differences in shear-wave sonoelastography (SWS) scores between the different parts of cervix, explore the association between the cervical SWS scores with cervical length and evaluate repeatability of the measurement of cervical SWS scores. MATERIAL AND METHOD...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1111/aogs.13874
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To compare two treatment strategies in women undergoing surgery for endometrial carcinoma. DESIGN:Retrospective cohort study. SETTING:Tertiary care center. POPULATION:1166 patients. Uterine biopsy/curettage was obtained in 1140 women, of whom 229 also had pelvic magnetic resonance imaging (MRI). METHODS:W...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12523
更新日期:2015-01-01 00:00:00
abstract::Using standardized laparoscopy technique, fluid was aspirated from the pouch of Douglas, from the Fallopian tubes and from ovarian cysts in 85 cases with clinical diagnosis of pelvic inflammatory disease (PID). The concentration of doxycycline in the aspirates was measured after oral ingestion of 200 mg of doxycycline...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.3109/00016347809155893
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Anal sphincter tears during vaginal delivery are a major cause of anal incontinence. We wanted to assess the incidence in a Norwegian county where primary repairs are performed in four hospitals using similar per- and postoperative protocol for the treatment of such injuries. METHODS:A postal questionnaire ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2004.00647.x
更新日期:2004-10-01 00:00:00
abstract::Progesterone was the principal therapeutic agent used in 40 cases of pre-eclamptic toxaemia. It was also given to 10 normal pregnant women who served as a control group. A significant fall in both the systolic and diastolic blood pressures was observed in 80% of the toxaemic patients. In all cases there was a marked i...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347509157760
更新日期:1975-01-01 00:00:00
abstract::Among a group of 249 women examined during 1969-1971 in Swedish hospitals because of amenorrhea after oral contraceptive therapy, 177 patients answered a follow-up questionnaire in April 1972. For purposes of study these latter patients were divided into Groups 1 (6-12 month amenorrhea, spontaneous recovery), 2 (12-3...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347309157095
更新日期:1973-01-01 00:00:00
abstract:OBJECTIVE:To assess the fraction of women who have heard of human papillomavirus (HPV) in four Nordic countries (Denmark, Iceland, Norway, and Sweden) and to study the correlates of this awareness, just before the vaccines were released. DESIGN:Population-based cross-sectional study by means of a questionnaire. Settin...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340802326373
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:To determine whether adequate trophoblastic migration and maternal placental perfusion occurs in cases of early pregnancy loss, we compared vessels in elective abortion decidua with those in spontaneous abortion decidua. METHODS:Elective abortion decidua at 5-11 weeks (n = 40) were compared with spontaneous...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340500501731
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:During the last years, the incidence of obstetric anal sphincter rupture (OASR) has increased markedly in Sweden, and significantly less frequently in Italy. Our objective was to explore if different delivery management may explain the variation in OASR incidences. METHODS:In a retrospective study, data fro...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,多中心研究
doi:10.1080/00016340701832661
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To study the efficacy of performing the tension-free vaginal tape (TVT) procedure concurrently with vaginal pelvic relaxation surgeries in the management of genuine stress incontinence with genital prolapse. MATERIALS AND METHODS:Fifty-eight women were surgically managed. Various vaginal pelvic reconstructiv...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2003.00316.x
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:To examine the theory that the postpartum shivering phenomenon is related to feto-maternal bleed during the third stage of labor. METHODS:One hundred laboring low-risk women who had a normal vaginal delivery were observed for the presence of postpartum chills. The duration of the first and second stages of l...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2001.080002149.x
更新日期:2001-02-01 00:00:00
abstract:INTRODUCTION:Emergency contraception must be followed by the use of an effective method of contraception in order to reduce future risk of unintended pregnancies. Provision of long-acting reversible contraception (LARC) is highly effective in this regard. The aim of our study was to compare use of an effective method o...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12916
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Despite the fact that preterm labor and birth account for the vast majority of neonatal morbidity and mortality the currently available treatment options are still far from satisfactory. The aim of this study was to investigate the effects of erythromycin on stretch-induced contractions of pregnant human myo...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2001.080008697.x
更新日期:2001-08-01 00:00:00
abstract:INTRODUCTION:Borderline ovarian tumors are typically indolent neoplasms. Since many are diagnosed in younger women, fertility conservation is an important consideration and has been advocated based on retrospective data. The objective of this study was to identify features impacting on recurrence and survival in a seri...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13203
更新日期:2017-11-01 00:00:00