Abstract:
BACKGROUND:Estrogen and progesterone immunoregulate the genital environment by expression of cytokines and growth factors. OBJECTIVE:To investigate the pattern of expression of T-helper cytokines during the ovarian cycle compared with women with chronic anovulation resistant to clomiphene citrate. HYPOTHESIS:Expression of T-helper cytokines in women with chronic anovulation may be different from the pattern in women with a normal ovarian cycle. METHODS:We evaluated 31 infertile women having laparoscopy for evaluation of tubal patency and evidence of ovulation in two groups during (a) the luteal phase (17 women) and (b) the follicular phase (14 women). A third group was composed of 14 women with polycystic ovarian syndrome, but they were resistant to clomiphene citrate for induction of ovulation and had laparoscopic ovarian cautery. Peritoneal fluid was collected during laparoscopy. Estimation of T-helper cytokine interleukin (IL)-2, tumor necrosis factor (TNF)-alpha, IL-4 and IL-6 in serum, peritoneal fluid and culture of the peritoneal mononuclear cells was performed by ELISA. Serum luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, estradiol and progesterone were evaluated by the Vidas Parametric System. RESULTS:The LH : FSH ratio was significantly higher in the women with polycystic ovaries than in the ovulatory groups. IL-2 and IFN-gamma were more highly expressed in the follicular phase but the T-helper 2 cytokines IL-4 and IL-6 predominated in the luteal phase, serum, peritoneal fluid and culture of the peritoneal mononuclear cells. From the follicular to the mid-luteal phase, IL-6 increased three to fivefold in the serum and peritoneal fluid, but there was low expression with anovulation. CONCLUSIONS:The peritoneal fluid levels of IL-4 and IL-6 are higher in the luteal phase. Low IL-6 levels in chronic anovulation may be a marker of resistance to clomiphene citrate.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
Omu AE,Al-Azemi MK,Makhseed M,Al-Oattan F,Ismail AA,Al-Tahir S,Al-Busiri Ndoi
10.1034/j.1600-0412.2003.00045.xsubject
Has Abstractpub_date
2003-07-01 00:00:00pages
603-9issue
7eissn
0001-6349issn
1600-0412pii
045journal_volume
82pub_type
杂志文章abstract:INTRODUCTION:The aim of our study was to compare the stage and severity of endometriosis in fertile and infertile women with congenital uterine malformations. MATERIAL AND METHODS:We performed an observational study from September 2007 to December 2015 in a tertiary care university hospital and assisted reproductive t...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13040
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:To determine whether adequate trophoblastic migration and maternal placental perfusion occurs in cases of early pregnancy loss, we compared vessels in elective abortion decidua with those in spontaneous abortion decidua. METHODS:Elective abortion decidua at 5-11 weeks (n = 40) were compared with spontaneous...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340500501731
更新日期:2006-01-01 00:00:00
abstract::Researchers in Copenhagen, Denmark conducted a study to determine if an IUD in a normal woman retards endometrial development. 14 Lippes loop users and 14 controls were studied. The device users had had their IUDs inserted at least 1 year previously and menstruated regularly. The basal temperature curve determined ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347309158323
更新日期:1973-01-01 00:00:00
abstract:BACKGROUND:Maternal symptoms such as severe headache, nausea and vomiting, visual disturbances and epigastric pain have been associated with complications in women with preeclampsia. OBJECTIVE:To determine the accuracy of maternal symptoms in predicting complications in women with preeclampsia by systematic review. D...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1600-0412.2011.01111.x
更新日期:2011-06-01 00:00:00
abstract:INTRODUCTION:When complications arise in the delivery room, midwives and obstetricians operate at the interface of life and death, and in rare cases the infant or the mother suffers severe and possibly fatal injuries related to the birth. This descriptive study investigated the numbers and proportions of obstetricians ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 评论,杂志文章
doi:10.1111/aogs.12897
更新日期:2016-07-01 00:00:00
abstract::Autosomal recessive polycystic kidney disease is a relatively rare congenital disease affecting the kidneys and liver. We noticed the kidney abnormality at 22 weeks gestation and observed the patient till the delivery at 36 weeks of gestation. The ultrasonographic features consisted of bilaterally enlarged hyperechoge...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349109007927
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:To analyse the expression of 15 genes encoding receptors and enzymes associated with the molecular mechanism of the tocolytic drugs atosiban (oxytocin receptor antagonist), nifedipine (calcium channel blocker) and celecoxib (selective cyclo-oxygenase-2 inhibitor) in preterm labor patients with premature ruptu...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.2012.01445.x
更新日期:2012-08-01 00:00:00
abstract::With advancing age, the postural balance function deteriorates as a consequence of decreased functional capacity. Deteriorating balance is a risk factor for bone fractures due to increased risks of falls. It has been suggested that the loss of estrogen, which occurs in relation to the menopause, may be associated with...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1080/00016340701207575
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The purpose of the study was to evaluate outcome, urodynamic correlates and adverse effects of laparoscopic colposuspension using polytetrafluoroethylene sutures. METHODS:Eighty-five consecutive women with primary stress urinary incontinence at one university hospital were included in this prospective non-c...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:2000-05-01 00:00:00
abstract::Using the registration of all pregnant women living within a particular geographical district of Copenhagen the risk of spontaneous abortion has been calculated by means of a decremental method. A total of 3,042 pregnancies were registered and the total risk of spontaneous abortion was calculated at 10 per cent. In 43...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348009154629
更新日期:1980-01-01 00:00:00
abstract::The purpose of this study was to determine the value of Gram stain examination and Limulus amebocyte lysate (LAL) test in the detection of intraamniotic infection. Ninety women with preterm labor and intact membranes (n = 55) or preterm premature rupture of membranes (PROM) (n = 35) who delivered prematurely were incl...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.3109/00016349509024449
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:Sexuality in spinal cord injured women has largely been neglected. One reason may be the male dominance amongst traumatically spinal cord injured individuals. The purpose of this study is to elucidate sexual issues in women with spinal cord injuries. METHODS:Survey of near-total prevalence population in the...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349709034913
更新日期:1997-11-01 00:00:00
abstract::Many studies concerning the various aspects of cesarean section have recently appeared in the literature. The important issues are the changing indications for the operation and the different management protocols in trial of labor following a previous cesarean section. As the different authors use different ways of pr...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348709022075
更新日期:1987-01-01 00:00:00
abstract::In 1969 the Scan-Gallup institution interviewed a random sample of 503 women from all parts of Norway who had given birth during the last 24 months. Cesarean sections and forceps deliveries were excluded. The interviews revealed that 69% of the women were left unattended for a considerable part of the delivery, that t...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348909009899
更新日期:1989-01-01 00:00:00
abstract::Blood residue levels of some organochlorine pesticides (DDT and its analogues, lindane, dieldrin, heptachlor epoxide) and polychlorinated biphenyls were measured in maternal and cord blood in 20 cases of premature rupture of fetal membranes at term and in 15 matched controls. No evidence of a possible organochlorine c...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349809004291
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Grand multiparous women in poor and under-privileged settings run a high risk of uterine rupture at labor induction. The purpose was to elucidate whether vaginal misoprostol medication is a safe and cost-effective alternative induction method in grand multiparous women, in whom, under prevailing circumstance...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:To determine the performance of trained midwives in second trimester ultrasound screening for fetal structural abnormalities in a low-risk population. DESIGN:Retrospective study. SETTING:University Department of Obstetrics and Gynecology. POPULATION:About 13,882 women with singleton pregnancies. METHODS:T...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340902934688
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:Follow-up after treatment for gynecological cancer demands large resources. There is a lack of evidence of efficacy. The aim of this survey was to explore follow-up routines and views on follow-up care among European experts in gynecological oncology. DESIGN:Web-based structured survey. SETTING:Survey distr...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.2012.01523.x
更新日期:2012-11-01 00:00:00
abstract::Conventional marsupialization was compared with incision plus curettage and primary suture of the abscess cavity under antibiotic (Clindamycin) cover in a prospective, randomized study of 32 patients with Bartholin's abscess. The median time to healing was 5 days less after suture than after marsupialization alone. Th...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016349209007949
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To validate the diagnosis of an unexplained antepartum fetal death in the Medical Birth Registry of Norway against data obtained from hospital records, alone and combined with autopsy data. To compare epidemiologic characteristics of an unexplained fetal death based on cases recorded by the three data sources...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2003.00009.x
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:To estimate time trends related to ectopic pregnancy while considering the contribution of repeat ectopic pregnancy and changing treatment for infertile couples over the past 24 years. METHODS:Population based incidence data on ectopic pregnancy were collected from the only two hospitals in one Norwegian cou...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349709050073
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of serum from infertile and fertile patients with endometriosis on the development of 2-cell mouse embryos. PATIENTS:Serum was obtained from 26 infertile patients and 8 fertile patients with endometriosis. Mouse embryo development in serum samples was compared using chi 2 analysis. RE...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349609054682
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Midwives in Sweden are responsible for taking Papanicolaou (Pap) smears as part of the cervical cancer screening program. The aim of this study was to investigate midwives knowledge, experience and management of the cervical cancer screening program, and their apprehension of women's knowledge about Pap-smea...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340701371272
更新日期:2007-01-01 00:00:00
abstract::The urinary excretion of histamine and its metabolites methylhistamine (MeHi) and methylimidazoleacetic acid (MeImAA) was measured during the menstrual cycle in nine healthy women, one allergic woman and three non-pregnant women with anovulatory regular cycles. Simultaneous urinary analyses of luteinizing hormone (LH)...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347609158501
更新日期:1976-01-01 00:00:00
abstract::We compared urodynamic findings and results of lateral urethrocystography in 84 case. The aim of the study was to establish a possible correlation between anatomic findings and functional results. Clinically, a significantly greater increase in the normal axis of urethral inclination was noted in patients with a urody...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349109006214
更新日期:1991-01-01 00:00:00
abstract::Over a period of 10 years, 645 patients were treated with six different betasympathomimetics because of threatening premature labor during the 24-36 weeks of gestation. Some 603 comparable patients were analysed with various parameters to find the most suitable criterion for assessing the efficacy of tocolysis and the...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.3109/00016348509156363
更新日期:1985-01-01 00:00:00
abstract::Laparoscopic sterilization with a bipolar electrode was performed in 62 patients. The sterilization failed in one patient and was questionable in another. The effectiveness was assessed by hysterosalpingography (HSG) in 51 patients. No complications due to laparoscopy occurred. The method is considered to be advantage...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347809155898
更新日期:1978-01-01 00:00:00
abstract::The concentrations of FSH, LH, 17-beta-estradiol (E2), estrone (E1) and progesterone (P) were measured in peripheral and ovarian vein sera obtained at preoperative pelvic angiography from 5 postmenopausal women with malignant ovarian tumors. In 5 others the concentrations of E2, P and testosterone (T) were also measur...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348609155172
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Cytochrome c oxidase is a marker enzyme of the mitochondrial inner membrane. A change in the structure and activity of cytochrome c oxidase may alter the electron transport in the inner membrane, leading to insufficient adenosine triphosphate (ATP) production. ATP is essential for maintaining the function of...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2004.00345.x
更新日期:2004-02-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to explore the outcome of low-risk singleton pregnancies with very short cervical length (CL ≤15 mm) according to method of treatment and CL at diagnosis. MATERIAL AND METHODS:Retrospective study on singleton pregnancies devoid of risk factors for spontaneous preterm delivery ide...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13881
更新日期:2020-11-01 00:00:00