Abstract:
INTRODUCTION:Borderline ovarian tumors are typically indolent neoplasms. Since many are diagnosed in younger women, fertility conservation is an important consideration and has been advocated based on retrospective data. The objective of this study was to identify features impacting on recurrence and survival in a series of borderline ovarian tumors, and to assess the safety of a fertility-sparing approach. MATERIAL AND METHODS:A historical cohort study of consecutive borderline ovarian tumors cases treated at a single institution over 30 years (1981-2011). Data on surgical approach (fertility-sparing or otherwise), disease stage, CA125 levels, histological features, adjuvant treatment and follow-up data were collected. Recurrence and survival were assessed using the Kaplan-Meier method and associations with the variables of interest were evaluated using a multivariate Cox proportional hazards model. RESULTS:213 patients were included. Of 132 women age 40 years and below at diagnosis, 112 (85%) had a fertility-sparing procedure and 60 (46%) had conservation of an involved ovary. Fifty patients (24%) developed recurrences; fertility preservation (hazard ratio = 2.57; 95% confidence interval 1.1-6; p = 0.029) and advanced stage (hazard ratio = 4.15; 95% confidence interval 2.3-7.6; p < 0.001) were independently associated with recurrence on multivariate analysis. Eleven (5%) patients died of their disease. Fertility preservation was not associated with compromised survival. CONCLUSIONS:Borderline ovarian tumors carry a good prognosis overall. Fertility preservation is associated with a higher risk of disease relapse; however, as most relapses are localized and may be salvaged with surgical treatment, overall survival is not compromised.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
Helpman L,Yaniv A,Beiner ME,Aviel-Ronen S,Perri T,Ben-Baruch G,Hogen Ben-David L,Jakobson-Setton A,Korach Jdoi
10.1111/aogs.13203subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1300-1306issue
11eissn
0001-6349issn
1600-0412journal_volume
96pub_type
杂志文章abstract:BACKGROUND:In the present study we report on the results of a retrospective study on the effect on survival of the pelvic lymphadenectomy in a group of 294 patients with stage Ia2-IIa cervical carcinoma treated by radical hysterectomy from 1984 through 1996 at the Leiden University Medical Center. METHODS:Lymphadenect...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To assess the prevalence of antenatal depressive disorder in different trimesters and to evaluate the relation of psychosocial risk factors to antenatal depressive disorder. DESIGN:Cohort follow-up. SETTING:University Hospital, Kaunas, Lithuania. SAMPLE:Two hundred and thirty pregnant women consecutively a...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340902846049
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To compare the diagnostic characteristics of the evaluation of myometrial invasion (MI) retrospectively between preoperative magnetic resonance imaging (MRI) and intraoperative frozen sections. DESIGN:A retrospective study. SETTING:University hospital. SAMPLE:201 women diagnosed with endometrial carcinoma....
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12048
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:The purpose of our study was to compare laser cone excision with large loop excision of the transformation zone with particular respect to the retrieval of endocervical cells on follow-up cervical cytology. METHODS:Retrospective analysis of case records of 368 women who had large loop excision of the transf...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349609033286
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:The objective of the study was to assess the relationship between maternal smoking habits and biomarkers of tobacco smoke measured in cord serum. METHODS:The study population comprised 202 mothers, 42 daily smokers, 24 occasional smokers and 136 nonsmokers. Information on maternal smoking habits was collect...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349609055025
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVES:Obstetric fistulas are severe sequelae of prolonged obstructed labor, a widespread but incompletely documented problem of low-income countries. Here, we characterize women with obstetric fistula, test the hypothesis that primi- and multipara represent different profiles and that fetal size is an important fa...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016341003801698
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:To investigate the levels of maternal serum secretory acetylcholinesterase from a sample of pregnancies involving fetal neural tube defects and compare those results with alphafetoprotein levels. METHODS:Secretory acetylcholinesterase levels were measured using a new Enzyme Capture Immunoassay, in a small b...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:Endometriosis is associated with an increased risk of dyspareunia, therefore this chronic gynecologic disease should be considered as a major cause of sexual dysfunctions. The aims of this study were to review the literature on the effects of surgical and pharmacological treatments for endometriosis on fem...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/aogs.13031
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:The Nordic countries are well-known high-incidence areas of ovarian cancer, but even within the Nordic countries, differences exist. METHODS:Focus in this descriptive epidemiological study is to assess developments in incidence and mortality of ovarian cancer in Denmark 1978-2002 and to make a comparison wi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2005.00878.x
更新日期:2005-10-01 00:00:00
abstract::When the placenta is located anteriorly, fetoscopy by the abdominal route may be impracticable. An alternative route, i.e., insertion of the fetoscope through the anterior vaginal fornix, was used in 31 women in midpregancy. Twenty-six of the women had been admitted for therapeutic abortion; the remaining five, for di...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348009155401
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVES:To evaluate if calcium supplementation during pregnancy could have any influence on primary dentition measured as the reduction of dental caries of the child. DESIGN:Individual randomized controlled trial. SETTING:One hospital in Rosario, Argentina. POPULATION:Random sample of 195 12-year-old children fro...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.3109/00016349.2010.518228
更新日期:2010-11-01 00:00:00
abstract:AIMS:This study describes the characteristics and per- and postoperative frequencies of complications in vaginal hysterectomies for benign lesions in patients with a history of cesareans. We compare these figures with the frequency of complications in vaginal hysterectomies without a history of such operations. PATIEN...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1046/j.1600-0412.2003.00247.x
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of early maternal feeding on maternal satisfaction and gastrointestinal complications on patients following simple and complicated caesarean delivery (CD). METHODS:A prospective, randomised study was designed including 179 women undergoing first or repeated CD. Women who were assigned ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1080/00016340701778849
更新日期:2008-01-01 00:00:00
abstract::Sciatic pain in a young woman was not relieved by orthopedic treatment. The gynecologist found a large hard tumor-like mass in the uterosacral ligament extending to the pelvic wall. Cytologic examination of fine needle aspirate indicated an endometriotic lesion. The large tumor-like mass was extirpated by an extraperi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348709092967
更新日期:1987-01-01 00:00:00
abstract:STUDY OBJECTIVE:To examine who may benefit from estrogen replacement therapy from a quality of life (QoL) perspective, taking both disease-specific and general aspects at baseline into account. DESIGN:A double-blind multi-center randomized placebo-controlled prospective study. The subjects were randomized to receive e...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/00016349509024430
更新日期:1995-05-01 00:00:00
abstract:INTRODUCTION:The objective of this study was to assess the effectiveness and potential benefits of the use of long-acting recombinant follicle-stimulating hormone (FSH) in a random-start protocol for fertility preservation in women with cancer. MATERIAL AND METHODS:This is a retrospective before-and-after study perfor...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13146
更新日期:2017-08-01 00:00:00
abstract::With advancing age, the postural balance function deteriorates as a consequence of decreased functional capacity. Deteriorating balance is a risk factor for bone fractures due to increased risks of falls. It has been suggested that the loss of estrogen, which occurs in relation to the menopause, may be associated with...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1080/00016340701207575
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To estimate the prevalence of fungi in the vagina, rectum and oral cavity in pregnant women with diabetes mellitus (DM) type I or gestational diabetes mellitus (GDM) and in healthy controls; to assess the influence of gestational age on the prevalence of fungi; to compare the vaginal symptoms within the grou...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2004.0361.x
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Unexplained antepartum stillbirth is a common cause of perinatal death, and identifying the fetus at risk is a challenge for obstetric practice. Intrauterine growth restriction (IUGR) is associated with a variety of adverse perinatal outcomes, but reports on its impact on unexplained stillbirths by populatio...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2004.00602.x
更新日期:2004-09-01 00:00:00
abstract::A case of non-obstructive cecal dilatation and perforation after cesarean section is reported, with a review of the literature on the diagnosis and management of this entity. Fifteen cases have been described. Attention is called to this rare complication and to the accompanying pseudo-obstructive syndrome, the diagno...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.3109/00016349009013309
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:To investigate the risk for anal sphincter tears (AST) in infibulated women. DESIGN:Population-based cohort study. SETTING:Nationwide study in Sweden. POPULATION:The study population included 250 491 primiparous women with a vaginal singleton birth at 37-41 completed gestational weeks during 1999-2008. We ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12010
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Emergent cervical cerclage is often unsuccessful in patients with severely protruding fetal membranes for the following reasons: (1) difficulty in pushing the bulging membranes into the cervix; (2) risk of premature rupture of membranes during the operative procedures; and (3) displacement of the cerclage ta...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:To estimate time trends related to ectopic pregnancy while considering the contribution of repeat ectopic pregnancy and changing treatment for infertile couples over the past 24 years. METHODS:Population based incidence data on ectopic pregnancy were collected from the only two hospitals in one Norwegian cou...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349709050073
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:To identify women having unsafe abortions and elucidate whether an acceptable follow-up rate among these women can be retrieved. STUDY POPULATION:One thousand three hundred and fifty-seven women attended Temeke Municipal Hospital, Dar es Salaam with an abortion-related diagnosis. METHODS:Women having unsafe...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2004.0529.x
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:This study was carried out to evaluate the efficacy of HPV-DNA (Human Papilloma Virus) testing as a triage strategy for persistent borderline and mild cytological abnormalities. METHODS:A prospective cross-sectional study involving 321 women registered between January and December 2001 with two smears showi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2003.00155.x
更新日期:2003-06-01 00:00:00
abstract::The T-cell marker of spontaneous rosettes with sheep erythrocytes was determined in 34 normal term-deliveries on the peripheral lymphocytes of the mother and the corresponding cord-blood lymphocytes of the newborn, immediately after delivery. A consistently lower level of E-rosette forming lymphocytes was observed in ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Worldwide rising cesarean section rates over the past decades have caused much concern. Studies on the association between cesarean section and maternal social background have reported conflicting results. METHODS:A cohort study, comprising 837,312 birth order one deliveries notified to the population-based...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340701417422
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:This study aims to summarize evidence on the relation between neighborhood deprivation and the risks for preterm birth, small-for-gestational age, and stillbirth. DESIGN:The design was a systematic review and meta-analysis. MAIN OUTCOME MEASURES:The main outcome measures included studies that directly comp...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,meta分析,评审
doi:10.1111/aogs.12430
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Augmented serum prolactin (PRL) levels have been implicated as a cause for infertility in patients with endometriosis. However, it has not been established whether this lactogenic hormone or its receptor (PRLR) have specific effects on the development of human endometriosis. In the present study we assessed ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2002.810102.x
更新日期:2002-01-01 00:00:00
abstract::The cervical mucus plug is a large, complex structure within the cervical canal that is shed shortly before or during labor. We propose that the cervical mucus plug fulfills critical 'gate-keeper' functions based on its physical and immunologic properties, which help prevent ascending infection and preterm labor. The ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.1080/00016340902852898
更新日期:2009-01-01 00:00:00