Increased hyaluronan and CD44 expressions in intravenous leiomyomatosis.

Abstract:

BACKGROUND:To determine the influence of hyaluronan and its receptor CD44 in the angiogenesis and invasiveness of intravenous leiomyomatosis (IVL). METHODS:Paraffin-embedded sections from four IVL cases and 10 uterine leiomyoma cases were immunohistochemically stained for CD34, CD44, basic fibroblast growth factor (bFGF), vascular endothelial growth factor, and platelet-derived growth factor and assayed for microvessel densities. Hyaluronan was immunostained by biotinylated hyaluronan-binding peptide and the results were clinically correlated. RESULTS:CD34 labeling showed significantly increased microvessel counts in IVL (156.6+/-3.7), when compared to uterine leiomyomas (61.3+/-27.3; P<0.001). Hyaluronan and its receptor CD44 were prominently expressed in IVL when compared to leiomyomas and associated with an elevation in bFGF expression. CONCLUSIONS:IVL is a highly vascular neoplasm with elevated microvessel counts. The increase of hyaluronan and CD44 expression in IVL suggests that it is highly angiogenic and has an invasive potential. Elevation of hyaluronan may play a possible role in the pathogenesis of IVL.

authors

Chen MJ,Peng Y,Yang YS,Huang SC,Chow SN,Torng PL

doi

10.1111/j.0001-6349.2005.00707.x

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

322-8

issue

4

eissn

0001-6349

issn

1600-0412

pii

AOG707

journal_volume

84

pub_type

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