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Comparison of ultrasound and autopsy findings in pregnancies terminated due to fetal anomalies.

Abstract：

OBJECTIVE:To compare antenatal diagnoses with autopsy findings in pregnancies terminated after ultrasound detection of fetal anomalies. A second aim was to study the quality of antenatal fetal diagnosis over time. DESIGN:Retrospective, multicenter study over two consecutive six-year periods in Uppsala and Stockholm. SETTING:Cases were identified through fetal autopsy reports. SUBJECTS:Three hundred and twenty-eight fetuses from pregnancies terminated between 1992 and 2003 because of ultrasonographically diagnosed anomalies. MAIN OUTCOME MEASURES:The findings at the last ultrasound examination were compared with the autopsy reports. RESULTS:In 299 cases (91.2%) ultrasound findings either exactly matched or were essentially similar to the autopsy findings. In 23 cases (7%) ultrasound findings were not confirmed at autopsy, but the postnatal findings were at least as severe as the antenatal ones. In six cases (1.8%) termination was performed for an anomaly which proved to be less severe than was predicted by ultrasound. The number of such cases was the same in both six-year periods, while the total number of cases increased from 113 in the first to 215 in the second period. Fetal examination provided further diagnostic information in 47% of the cases. In 10% a syndrome was disclosed. CONCLUSION:Termination of pregnancy was not always based on a correct antenatal diagnosis. All fetuses but one from terminated pregnancies had evident anomalies. In six cases (1.8%) the decision to terminate was based on suboptimal prognostic and diagnostic information. Fetal autopsy by an experienced perinatal pathologist is essential to provide a definitive diagnosis.

journal_name

Acta Obstet Gynecol Scand

journal_title

Acta obstetricia et gynecologica Scandinavica

authors

Amini H,Antonsson P,Papadogiannakis N,Ericson K,Pilo C,Eriksson L,Westgren M,Axelsson O

doi

10.1080/00016340600880886

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

1208-16

issue

10

eissn

0001-6349

issn

1600-0412

pii

757967216

journal_volume

85

pub_type

杂志文章

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