Abstract:
:To evaluate the role of parenteral and sexual transmission of human immunodeficiency virus, we studied seronegative intravenous drug users recruited from 25 drug dependence treatment centers in northern Italy. All attending intravenous drug users were asked for their consent and screened for antibodies to human immunodeficiency virus; those who were seronegative were enrolled, interviewed about their habits, and invited to follow-up visits. Between 1987 and 1989, 1,195 seronegative intravenous drug users were enrolled, 635 were followed up (mean duration, 11.9 months), and 35 seroconversions were observed. The incidence rate ratios were 3.3 (95% confidence interval (CI) 1.4-7.5) for subjects aged less than 20 years, 2.4 (95% CI 1.2-4.7) for less than 2 years of intravenous drug use, 2.2 (95% CI 0.9-5.5) for syringe sharing, and 1.0 for subjects with a sexual partner who had tested positive for human immunodeficiency virus. A case-control approach, using logistic regression and adjusting for sex, age, area, and prevalence, showed odds ratios of 13.2 (95% CI 3.1-56.8) for frequent syringe sharing and 4.0 (95% CI 1.5-10.4) for sexual contacts with seropositive partners; frequent use of condoms was associated with a reduction in risk that did not reach statistical significance. Parenteral transmission is the most important route of infection with the human immunodeficiency virus among intravenous drug users, and sexual transmission plays a relevant, additive role.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Nicolosi A,Leite ML,Musicco M,Molinari S,Lazzarin Adoi
10.1093/oxfordjournals.aje.a116275subject
Has Abstractpub_date
1992-02-01 00:00:00pages
225-33issue
3eissn
0002-9262issn
1476-6256journal_volume
135pub_type
杂志文章abstract::The analysis of injury data requires different considerations from the analysis of other types of outcomes because an individual can experience the outcome many times. When describing injury patterns using numerator-only data (e.g., proportion of upper-extremity injuries vs. lower-extremity injuries), simple compariso...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp265
更新日期:2009-11-15 00:00:00
abstract::The authors present a computer program for hypothesis testing and calculation of exact binomial confidence intervals for the adjusted relative risk in follow-up studies involving multiple strata with incidence density (person-time) denominators and small or zero person-count numerators. The program is an extension to ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114535
更新日期:1987-02-01 00:00:00
abstract::Population-based and proportional odds ratios for various cancers, based on incidence data from 1974-1977 and mortality data from 1965-1975 for western Washington State, were calculated in relation to three measures of exposure to asbestos in community water supplies. Six odds ratios were calculated for each neoplasm ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113415
更新日期:1982-08-01 00:00:00
abstract::Experimentally, high-carbohydrate diets have been shown to elevate triglycerides, but it has not been established whether this rise is permanent or transient. The authors approached this question by studying 719 boys from worldwide populations with marked differences in long-term carbohydrate intake. Fasting serum tri...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115497
更新日期:1990-02-01 00:00:00
abstract::The prenatal course, labor and delivery of 90 mothers of infants who died of Sudden Infant Death Syndrome (SIDS) in Connecticut from 1974 through 1976 were studied by hospital chart reviews. Charts of 90 pair-matched controls whose infants survived the first year of life were also examined. Significant associations we...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112897
更新日期:1980-03-01 00:00:00
abstract::In the summer of 1991, four inmates from prison A in Upstate New York died of multi-drug-resistant tuberculosis. To determine the extent of resistant tuberculosis at prison A and transmission patterns, the authors interviewed staff and reviewed medical records and inmate movement histories. Contact investigation resul...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117222
更新日期:1994-07-15 00:00:00
abstract::In the study of complex diseases, it may be important to test hypotheses related to gene-gene (G x G) interaction. The success of such studies depends critically on obtaining adequate sample sizes. In this paper, the author investigates sample size requirements for studies of G x G interaction, focusing on four study ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/155.5.478
更新日期:2002-03-01 00:00:00
abstract::Follicular lymphoma (FL) risk is strongly associated with germline genetic variation in human leukocyte antigen (HLA) class II. Cigarette smoking has been suggested to increase FL risk, primarily among women. We hypothesized that amino acids in HLA-antigen D-related β1 subunit (DRB1) interact with smoking in FL risk, ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kww118
更新日期:2017-04-15 00:00:00
abstract::This study examines the impact of military service on 13 categories of self-reported physical health problems by using a sample of 2,260 American male-male monozygotic twin pairs who served on active duty during the Vietnam War. Data were collected in 1987 by using mail and/or telephone interviews. Twins who served in...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115992
更新日期:1991-07-01 00:00:00
abstract::The analysis of the combined effects of nutritional factors with other putative disease determinants in log-linear or logistic models is methodologically complicated by the strong multicollinearity between nutritional factors, resulting in poor precision in estimating the parameters. Furthermore, the generally used mu...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117572
更新日期:1995-12-01 00:00:00
abstract::The Barnes Hospital Employee Health Service (St. Louis, Missouri) rubella screening program was evaluated over the 5-year period between January 1, 1986, and December 31, 1990. A total of 6,969 new employees were hired, and 6,115 (87.7%) were screened for evidence of rubella immunity by the Employee Health Service. Ru...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116913
更新日期:1993-11-01 00:00:00
abstract::To develop a method for assessing preclinical cardiovascular disease risk, models of resting cardiovascular regulation and of insulin metabolic syndrome were derived from information collected from 1991 to 1996 in a culturally heterogeneous sample of 319 healthy men and women (aged 25-44 years) from Miami-Dade County,...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/154.8.765
更新日期:2001-10-15 00:00:00
abstract::Previous studies have suggested an association between fetal growth restriction and the risk of spontaneous preterm birth (sPTB). However, addressing this association is methodologically challenging. We conducted a prospective cohort study of nulliparous women with a singleton pregnancy in Cambridge, United Kingdom (2...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwv345
更新日期:2016-07-15 00:00:00
abstract::A small number of prior epidemiologic studies of occupational noise exposure based on self-report have suggested an association with acoustic neuroma. The goal of the present study was to further examine the association between noise exposure and acoustic neuroma by using an objective measure of exposure in the form o...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm217
更新日期:2007-12-01 00:00:00
abstract::The relation between intake of fish and soy products and subsequent all-cause and cause-specific mortality was examined in a cohort of 13,355 male and 15,724 female residents of Takayama, Gifu, Japan. A diet that included soy and fish intake was assessed in 1992 by using a validated semiquantitative food frequency que...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwf118
更新日期:2002-11-01 00:00:00
abstract::The relationship between cataract prevalence, altitude, and sunlight hours was investigated in a large national probability sample survey of 105 sites in the Himalayan kingdom of Nepal, December 1980 through April 1981. Cataract of senile or unknown etiology was diagnosed by ophthalmologists in 873 of 30,565 full-time...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113632
更新日期:1983-08-01 00:00:00
abstract::More than a century of empirical evidence links marital status to mortality. However, the hazards of dying associated with long-term marital trajectories and contributing risk factors are largely unknown. The authors used 1992-2006 prospective data from a cohort of US adults to investigate the impact of current marita...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp194
更新日期:2009-09-01 00:00:00
abstract::Data from a case-control study conducted in New York State during 1982-1984 were used to evaluate the relation between alcohol consumption and estrogen receptor-positive and estrogen receptor-negative breast cancers and alcohol and various histologic subtypes. The cases were women between 20 and 79 years of age with a...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117205
更新日期:1994-12-01 00:00:00
abstract::Neutralizing antibodies to the Inoue-Melnick virus were detected in healthy adults in Osaka and in Houston. For adults, the prevalence rate for the cross-reacting type 3 virus was 13.8 per cent in Osaka and 29.1 per cent in Houston. Antibodies were also found in immune serum globulin prepared from American adults, but...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114560
更新日期:1987-03-01 00:00:00
abstract::The authors examined the association between the use of diethylstilbestrol during pregnancy and the risk of subsequent fatal breast cancer in a large prospective study of US adults. After 9 years of follow-up, 1,574 cases of fatal breast cancer were observed among 501,536 gravid women who reported no prior history of ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a008976
更新日期:1996-10-01 00:00:00
abstract::In the present study, the authors investigated the role of the intrauterine environment in childhood adiposity by comparing the maternal-offspring body mass index (BMI) association with the paternal-offspring BMI association when the offspring were 3 years of age, using parental prepregnancy BMI (measured as weight in...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kws134
更新日期:2012-07-15 00:00:00
abstract::Maternal concentrations of insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 1 (IGFBP-1) may influence fetal growth. Offspring birth weight related to maternal IGF-I and IGFBP-1 measured in pregnancy was studied in 368 randomly selected women without preeclampsia who delivered a singl...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr067
更新日期:2011-07-15 00:00:00
abstract::Dosemeci et al. (Am J Epidemiol 1990; 132:746-8) gave examples in which nondifferential misclassification of exposure reversed the direction of a trend. Gilbert (Am J Epidemiol 1991; 134:440-1) proposed that these examples occurred because the errors in exposure were systematic, and she pointed out that the relation b...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117283
更新日期:1994-09-15 00:00:00
abstract::The authors assessed the association between cognitive function and incidence and maintenance of overweight in preschool children. A population-based birth cohort was established in Menorca, Spain, between 1997 and 1999 (n = 482). Body mass index (weight (kg)/height (m)(2)) was measured at ages 4 years and 6 years (n ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp140
更新日期:2009-08-15 00:00:00
abstract::No large national studies of ethnic differences in blood pressure among children accounting for body size differences have been published, to the authors' knowledge. This report details the similarities and differences in systolic and diastolic blood pressures between Black children and White children in the United St...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a010129
更新日期:2000-05-15 00:00:00
abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant. Although experimental evidence suggests that TCDD alters thyroid hormone levels in rodents, human data are inconsistent. In 1976, a trichlorophenol plant exploded in Seveso, Italy. Women living in highly exposed areas were followed t...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwu160
更新日期:2014-09-01 00:00:00
abstract::Active surveillance to detect all patients with Guillain-Barré syndrome who had had onset of illness from July 1, 1976 through April 30, 1977 was undertaken in Michigan after indications that the syndrome might be associated with the National Influenza Immunization Program of 1976-1977. Hospital record room librarians...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113810
更新日期:1984-06-01 00:00:00
abstract::During the 1973 summer season, 27 employees and 35 overnight guests at the North Rim, Grand Canyon National Park, Arizona, acquired febrile illnesses compatibel with relapsing fever. Sixteen cases were confirmed by finding Borrelia spirochetes in peripheral blood smears or inoculated Swiss mice. Retrospective surveys ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112406
更新日期:1977-05-01 00:00:00
abstract::Pregnancy estrogens are substantially elevated in twin pregnancies and are likely to be more so in the case of dizygotic twins. If levels of pregnancy estrogens were positively related to breast cancer risk in the offspring, female twin members would be expected to be at slightly higher risk. Data from an internationa...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116444
更新日期:1992-12-01 00:00:00
abstract::Lung Health Study participants were smokers aged 35-60 years with mild lung function impairment who participated in a 5-year, 10-center (nine in the United States, one in Canada) clinical trial in 1986-1994. The authors compared the relation of randomized treatment assignments and of smoking history during the study w...
journal_title:American journal of epidemiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1093/aje/kwg083
更新日期:2003-06-01 00:00:00