Parenteral and sexual transmission of human immunodeficiency virus in intravenous drug users: a study of seroconversion. The Northern Italian Seronegative Drug Addicts (NISDA) Study.

Abstract:

:To evaluate the role of parenteral and sexual transmission of human immunodeficiency virus, we studied seronegative intravenous drug users recruited from 25 drug dependence treatment centers in northern Italy. All attending intravenous drug users were asked for their consent and screened for antibodies to human immunodeficiency virus; those who were seronegative were enrolled, interviewed about their habits, and invited to follow-up visits. Between 1987 and 1989, 1,195 seronegative intravenous drug users were enrolled, 635 were followed up (mean duration, 11.9 months), and 35 seroconversions were observed. The incidence rate ratios were 3.3 (95% confidence interval (CI) 1.4-7.5) for subjects aged less than 20 years, 2.4 (95% CI 1.2-4.7) for less than 2 years of intravenous drug use, 2.2 (95% CI 0.9-5.5) for syringe sharing, and 1.0 for subjects with a sexual partner who had tested positive for human immunodeficiency virus. A case-control approach, using logistic regression and adjusting for sex, age, area, and prevalence, showed odds ratios of 13.2 (95% CI 3.1-56.8) for frequent syringe sharing and 4.0 (95% CI 1.5-10.4) for sexual contacts with seropositive partners; frequent use of condoms was associated with a reduction in risk that did not reach statistical significance. Parenteral transmission is the most important route of infection with the human immunodeficiency virus among intravenous drug users, and sexual transmission plays a relevant, additive role.

journal_name

Am J Epidemiol

authors

Nicolosi A,Leite ML,Musicco M,Molinari S,Lazzarin A

doi

10.1093/oxfordjournals.aje.a116275

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

225-33

issue

3

eissn

0002-9262

issn

1476-6256

journal_volume

135

pub_type

杂志文章
  • Analyses of injury count data: some do's and don'ts.

    abstract::The analysis of injury data requires different considerations from the analysis of other types of outcomes because an individual can experience the outcome many times. When describing injury patterns using numerator-only data (e.g., proportion of upper-extremity injuries vs. lower-extremity injuries), simple compariso...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwp265

    authors: Shrier I,Steele RJ,Hanley J,Rich B

    更新日期:2009-11-15 00:00:00

  • Epidemiologic programs for computers and calculators. Exact binomial confidence intervals for the relative risk in follow-up studies with sparsely stratified incidence density data.

    abstract::The authors present a computer program for hypothesis testing and calculation of exact binomial confidence intervals for the adjusted relative risk in follow-up studies involving multiple strata with incidence density (person-time) denominators and small or zero person-count numerators. The program is an extension to ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114535

    authors: Guess HA,Lydick EG,Small RD,Miller LP

    更新日期:1987-02-01 00:00:00

  • Cancer incidence in relation to asbestos in drinking water in the Puget Sound region.

    abstract::Population-based and proportional odds ratios for various cancers, based on incidence data from 1974-1977 and mortality data from 1965-1975 for western Washington State, were calculated in relation to three measures of exposure to asbestos in community water supplies. Six odds ratios were calculated for each neoplasm ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113415

    authors: Polissar L,Severson RK,Boatman ES,Thomas DB

    更新日期:1982-08-01 00:00:00

  • Boys from populations with high-carbohydrate intake have higher fasting triglyceride levels than boys from populations with high-fat intake.

    abstract::Experimentally, high-carbohydrate diets have been shown to elevate triglycerides, but it has not been established whether this rise is permanent or transient. The authors approached this question by studying 719 boys from worldwide populations with marked differences in long-term carbohydrate intake. Fasting serum tri...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115497

    authors: West CE,Sullivan DR,Katan MB,Halferkamps IL,van der Torre HW

    更新日期:1990-02-01 00:00:00

  • Maternal and antenatal factors in the risk of sudden infant death syndrome.

    abstract::The prenatal course, labor and delivery of 90 mothers of infants who died of Sudden Infant Death Syndrome (SIDS) in Connecticut from 1974 through 1976 were studied by hospital chart reviews. Charts of 90 pair-matched controls whose infants survived the first year of life were also examined. Significant associations we...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112897

    authors: Arsenault PS

    更新日期:1980-03-01 00:00:00

  • Outbreak of multi-drug-resistant tuberculosis in a New York State prison, 1991.

    abstract::In the summer of 1991, four inmates from prison A in Upstate New York died of multi-drug-resistant tuberculosis. To determine the extent of resistant tuberculosis at prison A and transmission patterns, the authors interviewed staff and reviewed medical records and inmate movement histories. Contact investigation resul...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117222

    authors: Valway SE,Richards SB,Kovacovich J,Greifinger RB,Crawford JT,Dooley SW

    更新日期:1994-07-15 00:00:00

  • Sample size requirements for association studies of gene-gene interaction.

    abstract::In the study of complex diseases, it may be important to test hypotheses related to gene-gene (G x G) interaction. The success of such studies depends critically on obtaining adequate sample sizes. In this paper, the author investigates sample size requirements for studies of G x G interaction, focusing on four study ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/155.5.478

    authors: Gauderman WJ

    更新日期:2002-03-01 00:00:00

  • Possible Interaction Between Cigarette Smoking and HLA-DRB1 Variation in the Risk of Follicular Lymphoma.

    abstract::Follicular lymphoma (FL) risk is strongly associated with germline genetic variation in human leukocyte antigen (HLA) class II. Cigarette smoking has been suggested to increase FL risk, primarily among women. We hypothesized that amino acids in HLA-antigen D-related β1 subunit (DRB1) interact with smoking in FL risk, ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kww118

    authors: Baecklund F,Foo JN,Askling J,Eloranta S,Glimelius I,Liu J,Hjalgrim H,Rosenquist R,Padyukov L,Smedby KE

    更新日期:2017-04-15 00:00:00

  • A co-twin control study of the effects of the Vietnam War on the self-reported physical health of veterans.

    abstract::This study examines the impact of military service on 13 categories of self-reported physical health problems by using a sample of 2,260 American male-male monozygotic twin pairs who served on active duty during the Vietnam War. Data were collected in 1987 by using mail and/or telephone interviews. Twins who served in...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115992

    authors: Eisen SA,Goldberg J,True WR,Henderson WG

    更新日期:1991-07-01 00:00:00

  • Exploring the role of diet in modifying the effect of known disease determinants: application to risk factors of liver cirrhosis.

    abstract::The analysis of the combined effects of nutritional factors with other putative disease determinants in log-linear or logistic models is methodologically complicated by the strong multicollinearity between nutritional factors, resulting in poor precision in estimating the parameters. Furthermore, the generally used mu...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117572

    authors: Corrao G,Ferrari PA,Galatola G

    更新日期:1995-12-01 00:00:00

  • Results of a rubella screening program for hospital employees: a five-year review (1986-1990).

    abstract::The Barnes Hospital Employee Health Service (St. Louis, Missouri) rubella screening program was evaluated over the 5-year period between January 1, 1986, and December 31, 1990. A total of 6,969 new employees were hired, and 6,115 (87.7%) were screened for evidence of rubella immunity by the Employee Health Service. Ru...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116913

    authors: Fraser V,Spitznagel E,Medoff G,Dunagan WC

    更新日期:1993-11-01 00:00:00

  • Modeling preclinical cardiovascular risk for use in epidemiologic studies: Miami community health study.

    abstract::To develop a method for assessing preclinical cardiovascular disease risk, models of resting cardiovascular regulation and of insulin metabolic syndrome were derived from information collected from 1991 to 1996 in a culturally heterogeneous sample of 319 healthy men and women (aged 25-44 years) from Miami-Dade County,...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/154.8.765

    authors: Goldstein RZ,Hurwitz BE,Llabre MM,Schneiderman N,Gutt M,Skyler JS,Prineas RJ,Donahue RP

    更新日期:2001-10-15 00:00:00

  • Fetal Growth and the Risk of Spontaneous Preterm Birth in a Prospective Cohort Study of Nulliparous Women.

    abstract::Previous studies have suggested an association between fetal growth restriction and the risk of spontaneous preterm birth (sPTB). However, addressing this association is methodologically challenging. We conducted a prospective cohort study of nulliparous women with a singleton pregnancy in Cambridge, United Kingdom (2...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwv345

    authors: Partap U,Sovio U,Smith GC

    更新日期:2016-07-15 00:00:00

  • Occupational noise exposure and risk of acoustic neuroma.

    abstract::A small number of prior epidemiologic studies of occupational noise exposure based on self-report have suggested an association with acoustic neuroma. The goal of the present study was to further examine the association between noise exposure and acoustic neuroma by using an objective measure of exposure in the form o...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwm217

    authors: Edwards CG,Schwartzbaum JA,Nise G,Forssén UM,Ahlbom A,Lönn S,Feychting M

    更新日期:2007-12-01 00:00:00

  • Soy and fish oil intake and mortality in a Japanese community.

    abstract::The relation between intake of fish and soy products and subsequent all-cause and cause-specific mortality was examined in a cohort of 13,355 male and 15,724 female residents of Takayama, Gifu, Japan. A diet that included soy and fish intake was assessed in 1992 by using a validated semiquantitative food frequency que...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwf118

    authors: Nagata C,Takatsuka N,Shimizu H

    更新日期:2002-11-01 00:00:00

  • Associations among cataract prevalence, sunlight hours, and altitude in the Himalayas.

    abstract::The relationship between cataract prevalence, altitude, and sunlight hours was investigated in a large national probability sample survey of 105 sites in the Himalayan kingdom of Nepal, December 1980 through April 1981. Cataract of senile or unknown etiology was diagnosed by ophthalmologists in 873 of 30,565 full-time...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113632

    authors: Brilliant LB,Grasset NC,Pokhrel RP,Kolstad A,Lepkowski JM,Brilliant GE,Hawks WN,Pararajasegaram R

    更新日期:1983-08-01 00:00:00

  • Marital trajectories and mortality among US adults.

    abstract::More than a century of empirical evidence links marital status to mortality. However, the hazards of dying associated with long-term marital trajectories and contributing risk factors are largely unknown. The authors used 1992-2006 prospective data from a cohort of US adults to investigate the impact of current marita...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwp194

    authors: Dupre ME,Beck AN,Meadows SO

    更新日期:2009-09-01 00:00:00

  • Alcohol consumption and breast cancer: estrogen receptor status and histology.

    abstract::Data from a case-control study conducted in New York State during 1982-1984 were used to evaluate the relation between alcohol consumption and estrogen receptor-positive and estrogen receptor-negative breast cancers and alcohol and various histologic subtypes. The cases were women between 20 and 79 years of age with a...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117205

    authors: Nasca PC,Liu S,Baptiste MS,Kwon CS,Jacobson H,Metzger BB

    更新日期:1994-12-01 00:00:00

  • Antibody survey for Inoue-Melnick virus infections in Osaka and Houston.

    abstract::Neutralizing antibodies to the Inoue-Melnick virus were detected in healthy adults in Osaka and in Houston. For adults, the prevalence rate for the cross-reacting type 3 virus was 13.8 per cent in Osaka and 29.1 per cent in Houston. Antibodies were also found in immune serum globulin prepared from American adults, but...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114560

    authors: Inoue YK,Nishibe Y,Kimura T,Melnick JL

    更新日期:1987-03-01 00:00:00

  • Diethylstilbestrol and risk of fatal breast cancer in a prospective cohort of US women.

    abstract::The authors examined the association between the use of diethylstilbestrol during pregnancy and the risk of subsequent fatal breast cancer in a large prospective study of US adults. After 9 years of follow-up, 1,574 cases of fatal breast cancer were observed among 501,536 gravid women who reported no prior history of ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a008976

    authors: Calle EE,Mervis CA,Thun MJ,Rodriguez C,Wingo PA,Heath CW Jr

    更新日期:1996-10-01 00:00:00

  • Parent-offspring body mass index associations in the Norwegian Mother and Child Cohort Study: a family-based approach to studying the role of the intrauterine environment in childhood adiposity.

    abstract::In the present study, the authors investigated the role of the intrauterine environment in childhood adiposity by comparing the maternal-offspring body mass index (BMI) association with the paternal-offspring BMI association when the offspring were 3 years of age, using parental prepregnancy BMI (measured as weight in...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kws134

    authors: Fleten C,Nystad W,Stigum H,Skjaerven R,Lawlor DA,Davey Smith G,Naess O

    更新日期:2012-07-15 00:00:00

  • Maternal concentrations of insulin-like growth factor I and insulin-like growth factor binding protein 1 during pregnancy and birth weight of offspring.

    abstract::Maternal concentrations of insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 1 (IGFBP-1) may influence fetal growth. Offspring birth weight related to maternal IGF-I and IGFBP-1 measured in pregnancy was studied in 368 randomly selected women without preeclampsia who delivered a singl...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwr067

    authors: Åsvold BO,Eskild A,Jenum PA,Vatten LJ

    更新日期:2011-07-15 00:00:00

  • When will nondifferential misclassification of an exposure preserve the direction of a trend?

    abstract::Dosemeci et al. (Am J Epidemiol 1990; 132:746-8) gave examples in which nondifferential misclassification of exposure reversed the direction of a trend. Gilbert (Am J Epidemiol 1991; 134:440-1) proposed that these examples occurred because the errors in exposure were systematic, and she pointed out that the relation b...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117283

    authors: Weinberg CR,Umbach DM,Greenland S

    更新日期:1994-09-15 00:00:00

  • Cognitive function and overweight in preschool children.

    abstract::The authors assessed the association between cognitive function and incidence and maintenance of overweight in preschool children. A population-based birth cohort was established in Menorca, Spain, between 1997 and 1999 (n = 482). Body mass index (weight (kg)/height (m)(2)) was measured at ages 4 years and 6 years (n ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwp140

    authors: Guxens M,Mendez MA,Julvez J,Plana E,Forns J,Basagaña X,Torrent M,Sunyer J

    更新日期:2009-08-15 00:00:00

  • Blood pressure differences between blacks and whites in relation to body size among US children and adolescents.

    abstract::No large national studies of ethnic differences in blood pressure among children accounting for body size differences have been published, to the authors' knowledge. This report details the similarities and differences in systolic and diastolic blood pressures between Black children and White children in the United St...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a010129

    authors: Rosner B,Prineas R,Daniels SR,Loggie J

    更新日期:2000-05-15 00:00:00

  • Serum dioxin concentrations and thyroid hormone levels in the Seveso Women's Health Study.

    abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant. Although experimental evidence suggests that TCDD alters thyroid hormone levels in rodents, human data are inconsistent. In 1976, a trichlorophenol plant exploded in Seveso, Italy. Women living in highly exposed areas were followed t...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwu160

    authors: Chevrier J,Warner M,Gunier RB,Brambilla P,Eskenazi B,Mocarelli P

    更新日期:2014-09-01 00:00:00

  • Guillain-Barré syndrome and its relationship to swine influenza vaccination in Michigan, 1976-1977.

    abstract::Active surveillance to detect all patients with Guillain-Barré syndrome who had had onset of illness from July 1, 1976 through April 30, 1977 was undertaken in Michigan after indications that the syndrome might be associated with the National Influenza Immunization Program of 1976-1977. Hospital record room librarians...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113810

    authors: Breman JG,Hayner NS

    更新日期:1984-06-01 00:00:00

  • Tick-borne relapsing fever: an interstate outbreak originating at Grand Canyon National Park.

    abstract::During the 1973 summer season, 27 employees and 35 overnight guests at the North Rim, Grand Canyon National Park, Arizona, acquired febrile illnesses compatibel with relapsing fever. Sixteen cases were confirmed by finding Borrelia spirochetes in peripheral blood smears or inoculated Swiss mice. Retrospective surveys ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112406

    authors: Boyer KM,Munford RS,Maupin GO,Pattison CP,Fox MD,Barnes AM,Jones WL,Maynard JE

    更新日期:1977-05-01 00:00:00

  • Twin membership and breast cancer risk.

    abstract::Pregnancy estrogens are substantially elevated in twin pregnancies and are likely to be more so in the case of dizygotic twins. If levels of pregnancy estrogens were positively related to breast cancer risk in the offspring, female twin members would be expected to be at slightly higher risk. Data from an internationa...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116444

    authors: Hsieh CC,Lan SJ,Ekbom A,Petridou E,Adami HO,Trichopoulos D

    更新日期:1992-12-01 00:00:00

  • Changes in smoking status affect women more than men: results of the Lung Health Study.

    abstract::Lung Health Study participants were smokers aged 35-60 years with mild lung function impairment who participated in a 5-year, 10-center (nine in the United States, one in Canada) clinical trial in 1986-1994. The authors compared the relation of randomized treatment assignments and of smoking history during the study w...

    journal_title:American journal of epidemiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/aje/kwg083

    authors: Connett JE,Murray RP,Buist AS,Wise RA,Bailey WC,Lindgren PG,Owens GR,Lung Health Study Research Group.

    更新日期:2003-06-01 00:00:00