A numerical simulation of intimal thickening under shear in arteries.

Abstract:

:A model of intima thickening proposed by Friedman and his coworkers (1,2) is incorporated in our computer code to simulate the growth of intima under shear. The computer code is based on a finite volume method in a boundary-fitted coordinate system. It is found that the model yields an evenly-distributed thickening over a straight, smooth vessel wall. However, in a stenosed or a curved artery, thicker intima can be formed in preferential regions due to unevenly-distributed wall shear stresses. The results clearly demonstrate the correlations among the geometry, wall shear rate and the plaque localization in arteries. The model is applied to a straight artery with a stenosis or sinus, a smooth curved artery and a stenosed curved artery. The effects of stenosis/sinus and lumen curvature on the flows and the intimal thickening are studied. The simulation provides a numerical visualization of the intimal thickening in a dynamic way.

journal_name

Biorheology

journal_title

Biorheology

authors

Lee D,Chiu JJ

doi

10.3233/bir-1992-292-312

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

337-51

issue

2-3

eissn

0006-355X

issn

1878-5034

journal_volume

29

pub_type

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