Abstract:
:A model of intima thickening proposed by Friedman and his coworkers (1,2) is incorporated in our computer code to simulate the growth of intima under shear. The computer code is based on a finite volume method in a boundary-fitted coordinate system. It is found that the model yields an evenly-distributed thickening over a straight, smooth vessel wall. However, in a stenosed or a curved artery, thicker intima can be formed in preferential regions due to unevenly-distributed wall shear stresses. The results clearly demonstrate the correlations among the geometry, wall shear rate and the plaque localization in arteries. The model is applied to a straight artery with a stenosis or sinus, a smooth curved artery and a stenosed curved artery. The effects of stenosis/sinus and lumen curvature on the flows and the intimal thickening are studied. The simulation provides a numerical visualization of the intimal thickening in a dynamic way.
journal_name
Biorheologyjournal_title
Biorheologyauthors
Lee D,Chiu JJdoi
10.3233/bir-1992-292-312subject
Has Abstractpub_date
1992-03-01 00:00:00pages
337-51issue
2-3eissn
0006-355Xissn
1878-5034journal_volume
29pub_type
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