Abstract:
:Ciliary metachronism and motility were examined optically in tissue cultures from frog palate epithelium as a function of extracellular ATP concentration in the range of 10(-7)-10(-3) M. The main findings were: a) upon addition of ATP the metachronal wavelength increased by a factor of up to 2. b) the velocity of the metachronal wave increased by a factor of up to 5. c) the frequency of ciliary beating increased by a factor of up to 2-3, the increase being temperature insensitive in the range of 15 degrees C-25 degrees C. d) the area under the 1-second FFT spectrum decreased by a factor of up to 2.5. e) the energy of the metachronal wave is increased by a factor of up to 9.5. f) all the spectrum parameters are subject to influence by ATP, as also by ADP and AMP. However, there are pronounced differences in the various responses to them. Based on these findings, physical aspects of the rate increase of particle transport caused by addition of extracellular ATP are explained. A plausible overall chemical mechanism causing pronounced changes in ciliary motility is discussed.
journal_name
Biorheologyjournal_title
Biorheologyauthors
Ovadyahu D,Eshel D,Priel Zdoi
10.3233/bir-1988-25309subject
Has Abstractpub_date
1988-01-01 00:00:00pages
489-501issue
3eissn
0006-355Xissn
1878-5034journal_volume
25pub_type
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