Double-blind, randomized, multicenter study comparing the effect of betahistine and flunarizine on the dizziness handicap in patients with recurrent vestibular vertigo.

Abstract:

OBJECTIVE:The aim of this double-blind, randomized, multicenter study was to compare the efficacy of betahistine dihydrochloride (BH) and flunarizine (FL) using the Dizziness Handicap Inventory (DHI), a validated self-assessment questionnaire that has not previously been used in a clinical trial to evaluate antivertigo drugs. MATERIAL AND METHODS:Patients with recurrent vertigo of peripheral vestibular origin and who were severely handicapped by vertigo were randomized to an 8-week course of treatment with oral BH 48 mg daily or oral FL 10 mg daily. The efficacy endpoints were the total DHI score and the physical, functional and emotional subscores. RESULTS:Fifty-two patients completed the study. After 8 weeks of treatment the mean total DHI score and the physical subscore were significantly lower in the BH group compared to the FL group (7.5 and 3.6 points, respectively). The mean total DHI score as well as the three subscores decreased significantly after 4 and 8 weeks in both treatment groups. CONCLUSION:This study showed that at 8 weeks BH is significantly more effective than FL in terms of improving the total DHI score and the physical subscore. It was also established that the DHI is a useful and reliable method for evaluating the efficacy of antivertigo drugs.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Albera R,Ciuffolotti R,Di Cicco M,De Benedittis G,Grazioli I,Melzi G,Mira E,Pallestrini E,Passali D,Serra A,Vicini C

doi

10.1080/00016480310001475

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

588-93

issue

5

eissn

0001-6489

issn

1651-2251

journal_volume

123

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    journal_title:Acta oto-laryngologica

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    doi:10.3109/00016489509139392

    authors: Payman RN,Wall C 3rd,Ash-Bernal R

    更新日期:1995-11-01 00:00:00

  • Analysis of curves Na-24 efflux from membrane labyrinth containing stria vascularis.

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    doi:10.3109/00016487509121308

    authors: Mnich Z

    更新日期:1975-07-01 00:00:00

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    authors: Li YD,Li YH,Zhao Y,Wang JJ,Xie PL,Guo FJ,Ren CP,Li GC

    更新日期:2012-06-01 00:00:00

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    journal_title:Acta oto-laryngologica

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    doi:10.1080/00016489.2019.1666213

    authors: Yilmaz N,Ila K

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    doi:10.3109/00016489109100760

    authors: Svinhufvud M,Prellner K,Hermansson A,Schalén C

    更新日期:1991-01-01 00:00:00

  • Endoscope-assisted retrosigmoid keyhole approach for cerebellopontine angle: cadaveric study.

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    journal_title:Acta oto-laryngologica

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    authors: Sun JQ,Sun JW

    更新日期:2013-11-01 00:00:00

  • Schwannoma (neurilemmoma) of the tongue.

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    doi:10.1080/00016480500527219

    authors: Hsu YC,Hwang CF,Hsu RF,Kuo FY,Chien CY

    更新日期:2006-08-01 00:00:00

  • Substance P nerve fibres in the canine larynx by PAP immunohistochemistry.

    abstract::The distribution of the Substance P (SP) immunoreactive nerve fibres in the canine larynx and laryngeal nerves was studied by PAP immunohistochemistry. Many individual SP immunoreactive nerve fibres with varicosities were observed within the epithelial layer and in the connective tissue below the epithelium of the lar...

    journal_title:Acta oto-laryngologica

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    doi:10.3109/00016488509108597

    authors: Hisa Y,Sato F,Fukui K,Ibata Y,Mizukoshi O

    更新日期:1985-07-01 00:00:00

  • Evaluation of nasal cavity by acoustic rhinometry in Chinese, Malay and Indian ethnic groups.

    abstract::Acoustic rhinometry (AR) evaluates the geometry of the nasal cavity by measuring the minimum cross-sectional area (MCA) and nasal volume (V) by means of acoustic reflection. Understanding the normal and pathologic conditions of the internal nasal cavity using AR is important in the diagnosis of structural abnormalitie...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480152602311

    authors: Huang ZL,Wang DY,Zhang PC,Dong F,Yeoh KH

    更新日期:2001-10-01 00:00:00

  • Nasal physiology in swimmers and swimmers' sinusitis.

    abstract::To investigate the pathogenesis of swimmers' sinusitis we questioned and examined a group of 20 swimmers and 20 controls. Clinical examination was followed by rhinomanometry, sonography of the maxillary sinuses, a saccharine test to assess mucociliary transport in the nose, and a viable cytological sampling of the nas...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489009122550

    authors: Deitmer T,Scheffler R

    更新日期:1990-09-01 00:00:00

  • Vestibulo-ocular reflex (VOR) biases in normal subjects and patients with compensated vestibular loss.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489509139351

    authors: Katsarkas A,Galiana HL,Smith HL

    更新日期:1995-07-01 00:00:00

  • Dynamic measurement of gas composition in the middle ear. II: Steady state values.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489309135824

    authors: Sadé J,Luntz M

    更新日期:1993-05-01 00:00:00

  • Six cases of Forestier syndrome, a rare cause of dysphagia.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480500504192

    authors: Aydin E,Akdogan V,Akkuzu B,Kirbaş I,Ozgirgin ON

    更新日期:2006-07-01 00:00:00

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    pub_type: 杂志文章

    doi:10.3109/00016489109137412

    authors: Pruszewicz A,Obrebowski A,Swidziński P,Demeńko G,Wika T,Wojciechowska A

    更新日期:1991-01-01 00:00:00

  • Plaster of Paris and hair cell morphology. A scanning electron microscopic study of an alternative implant material for ear surgery.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488809122254

    authors: Högset O,Bredberg G

    更新日期:1988-11-01 00:00:00

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    abstract::Luetic hydrops can occur in both congenital and acquired lues and otologic manifestations may be indistinguishable from Meniere's disease. Eight endolymphatic sac decompression procedures were performed on 6 patients with refractory luetic vertigo. Of those, 3 had congenital and 3 acquired lues. All cases had received...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488009127172

    authors: Paparella MM,Kim CS,Shea DA

    更新日期:1980-05-01 00:00:00

  • Embryogenesis of the inner ear. II. The late differentiation of the mammalian crista ampullaris in vivo and in vitro.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488309132868

    authors: Nordemar H

    更新日期:1983-07-01 00:00:00

  • A hydrogel coating for cochlear implant arrays with encapsulated adipose-derived stem cells allows brain-derived neurotrophic factor delivery.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2013.878809

    authors: Schendzielorz P,Scherzed A,Rak K,Völker J,Hagen R,Mlynski R,Frölich K,Radeloff A

    更新日期:2014-05-01 00:00:00

  • Cross-coupling between horizontal and vertical eye movements during optokinetic nystagmus and optokinetic afternystagmus elicited in microgravity.

    abstract::The occurrence of horizontal jerks with larger amplitudes than on Earth was observed during vertical optokinetic nystagmus in astronauts tested throughout a 7-day spaceflight. During early exposure to microgravity, a horizontal spontaneous-like nystagmus was recorded in darkness following both vertical and horizontal ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489009107432

    authors: Clement G,Berthoz A

    更新日期:1990-03-01 00:00:00

  • N1 action potentials in humans: influence of simultaneous contralateral stimulation.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488709107792

    authors: Folsom RC,Owsley RM

    更新日期:1987-05-01 00:00:00

  • Developing a predictive model for vertigo using demographic and laboratory data: An evidence-based medicine approach.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480510043468

    authors: Yuan BC,Tzeng HM

    更新日期:2006-01-01 00:00:00

  • The role of alternative GJB2 transcription in screening for neonatal sensorineural deafness in Austria.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2016.1249946

    authors: Parzefall T,Lucas T,Koenighofer M,Ramsebner R,Frohne A,Czeiger S,Baumgartner WD,Schoefer C,Gstoettner W,Frei K

    更新日期:2017-04-01 00:00:00

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489609137829

    authors: Kubo T,Iwaki T,Ohkusa M,Doi K,Uno A,Yamamoto K,Fujii K

    更新日期:1996-03-01 00:00:00

  • Histological study of chronic electrode implantation through the round window of the guinea pig.

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    doi:10.3109/00016488809097005

    authors: Gyo K

    更新日期:1988-03-01 00:00:00

  • The olfactory and respiratory epithelium in rhesus and squirrel monkeys studied with freeze-fracture technique.

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    doi:10.3109/00016488909125526

    authors: Engström B,Ekblom A,Hansson P

    更新日期:1989-09-01 00:00:00

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,随机对照试验

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    journal_title:Acta oto-laryngologica

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    doi:10.3109/00016489109138421

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    更新日期:2014-10-01 00:00:00