Rescue therapy with tacrolimus in a patient with toxic megacolon.


BACKGROUND:Toxic megacolon is a life-threatening complication most commonly observed in patients with ulcerative colitis or Crohn's disease that is characterized by total or segmental nonobstructive colonic dilatation of at least 6 cm on plain abdominal films associated with systemic toxicity. CASE REPORT:We report an unusual case of fulminant steroid-refractory ulcerative colitis complicated by toxic megacolon treated successfully with the immunosuppressant tacrolimus. CONCLUSION:Tacrolimus administration induced clinical remission and bridged the time interval, until the standard immunosuppressant azathioprine could maintain clinical remission, thereby avoiding eminent emergency colectomy.


Int J Colorectal Dis


Pascu M,Müller AR,Wiedenmann B,Dignass AU




Has Abstract


2003-05-01 00:00:00












  • An assessment of inflammation in the reservoir after restorative proctocolectomy with ileoanal ileal reservoir.

    abstract::The significance of inflammation of the mucosa of the ileal reservoir after restorative proctocolectomy is not known although in some cases it appears to be associated with symptoms when the condition has been referred to as pouchitis. This investigation has aimed to determined the prevalence of inflammation, to defin...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Moskowitz RL,Shepherd NA,Nicholls RJ

    更新日期:1986-07-01 00:00:00

  • Factors associated with complete local excision of small rectal carcinoid tumor.

    abstract:PURPOSE:Although small rectal carcinoid tumors can be treated using local excision, complete resection can be difficult because tumors are located in the submucosal layer. We evaluate the factors associated with pathologically complete local resection of rectal carcinoid tumors. METHODS:Data were analyzed of 161 patie...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Son HJ,Sohn DK,Hong CW,Han KS,Kim BC,Park JW,Choi HS,Chang HJ,Oh JH

    更新日期:2013-01-01 00:00:00

  • Distance to hospital is not a risk factor for emergency colon cancer surgery.

    abstract:PURPOSE:The purpose of this study is to see if the distance to a hospital performing colon cancer surgery is a risk factor for emergency surgical intervention and to determine the variability between defined but demographically divergent catchment areas. METHODS:Data on patients living in Västerbotten County who under...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Blind N,Strigård K,Gunnarsson U,Brännström F

    更新日期:2018-09-01 00:00:00

  • Anal endosonography for assessment of anal incontinence with a linear probe: relationships with clinical and manometric features.

    abstract:BACKGROUND AND AIMS:This study determined correlations of clinical and manometric features with those of anal endosonography (AES). PATIENTS AND METHODS:Between 1996 and 1999 we examined 58 patients suffering from anal incontinence (AI) by AES using a linear probe and anorectal manometry following a standardized proto...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Barthet M,Bellon P,Abou E,Portier F,Berdah S,Lesavre N,Orsoni P,Bouvier M,Grimaud JC

    更新日期:2002-03-01 00:00:00

  • Questions on life satisfaction (FLZM) in inflammatory bowel disease.

    abstract:BACKGROUND AND AIMS:When assessing quality of care the outcome in terms of quality of life (QOL) is of major significance. This study examined QOL in IBD outpatients and the contribution of individual expectations and various other factors including disease activity. PATIENTS AND METHODS:The study included 306 outpati...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Janke KH,Raible A,Bauer M,Clemens P,Meisner C,Häuser W,Steder-Neukamm U,Henrich G,Herschbach P,Gregor M,Klump B

    更新日期:2004-07-01 00:00:00

  • Efficacy of indocyanine green fluorescence angiography in preventing anastomotic leakage after laparoscopic colorectal cancer surgery.

    abstract:PURPOSE:Some recent studies have suggested that fluorescence angiography with indocyanine green (ICG) might be useful for preventing anastomotic leakage (AL) after laparoscopic colorectal surgery. However, its efficacy has not been proven. We evaluated whether intraoperative ICG fluorescence angiography could decrease ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Ishii M,Hamabe A,Okita K,Nishidate T,Okuya K,Usui A,Akizuki E,Satoyoshi T,Takemasa I

    更新日期:2020-02-01 00:00:00

  • Overall survival is improved in mucinous adenocarcinoma of the colon.

    abstract:INTRODUCTION:Debate persists regarding the relationship between mucin expression and outcome in colon cancer. This arises due to discrepancy in the definition of mucinous adenocarcinoma and the combination of both colon and rectal cancers in analyses. This study examines the relationship between increased mucin product...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Hogan J,Burke JP,Samaha G,Condon E,Waldron D,Faul P,Coffey JC

    更新日期:2014-05-01 00:00:00

  • Primary resection and synchronous regional hepatic chemotherapy or cryotherapy for colorectal cancer with liver metastases.

    abstract::Twenty-two patients with colorectal cancer and synchronous unresectable hepatic metastases were treated by resection the primary tumour with concurrent insertion of an Infusaid infusaport system for regional chemoperfusion (hepatic arterial 20, portal venous 2). Four patients in addition had cryotherapy the liver meta...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Dasappa V,Ross WB,King J,King DW,Clingan PR,Morris DL

    更新日期:1996-01-01 00:00:00

  • CT assessment of the quality of omentoplasty and its implications for perineal wound healing.

    abstract:PURPOSE:This study was designed to examine the impact of an omentoplasty and its quality on pelviperineal morbidity after abdominoperineal resection (APR) for rectal cancer. METHODS:This was a retrospective single-centre study of consecutive patients undergoing APR for primary or recurrent rectal cancer between 2000 a...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Blok RD,Sharabiany S,Ferrett CG,Hompes R,Tanis PJ,Cunningham C

    更新日期:2019-11-01 00:00:00

  • Learning curve for robotic-assisted laparoscopic rectal cancer surgery.

    abstract:INTRODUCTION:One of the main uses of robotic assisted abdominal surgery is the mesorectal excision in patients with rectal cancer. The aim of the present study is to analyse the learning curve for robotic assisted laparoscopic resection of rectal cancer. PATIENTS AND METHODS:We included in our study 43 consecutive rec...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Jiménez-Rodríguez RM,Díaz-Pavón JM,de la Portilla de Juan F,Prendes-Sillero E,Dussort HC,Padillo J

    更新日期:2013-06-01 00:00:00

  • Flexible endoscopy is enough diagnostic prior to loop ileostomy reversal.

    abstract:PURPOSE:This study investigates whether contrast enema (CE) and flexible endoscopy (FE) should be performed routinely after low anterior resection (LAR) before ileostomy reversal. Additionally, the impact of previous anastomotic leakage (AL) on diagnostic test accuracy (DTA) was assessed. METHODS:This is a retrospecti...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Lindner S,von Rudno K,Gawlitza J,Hardt J,Sandra-Petrescu F,Seyfried S,Kienle P,Reissfelder C,Bogner A,Herrle F

    更新日期:2021-02-01 00:00:00

  • Measurement of the anorectal angle by defecography for the diagnosis of fecal incontinence.

    abstract::We assessed the reliability of anorectal angle (ARA) measurement as an index of fecal incontinence. The "posterior" ARA was measured at rest, squeezing, and straining in 69 continent and 82 incontinent subjects all complaining of various evacuation dysfunctions. The two groups were homogeneous with regard to sex distr...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Piloni V,Fioravanti P,Spazzafumo L,Rossi B

    更新日期:1999-04-01 00:00:00

  • Skeletal muscle mass and quality as risk factors for postoperative outcome after open colon resection for cancer.

    abstract:BACKGROUND:The prevalence of colorectal cancer in the elderly is increasing and, therefore, surgical interventions with a risk of potential complications are more frequently performed. This study investigated the role of low skeletal muscle mass (sarcopenia), muscle quality, and the sarcopenic obesity as prognostic fac...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Boer BC,de Graaff F,Brusse-Keizer M,Bouman DE,Slump CH,Slee-Valentijn M,Klaase JM

    更新日期:2016-06-01 00:00:00

  • Macrophages promote tumour growth and liver metastasis in an orthotopic syngeneic mouse model of colon cancer.

    abstract:PURPOSE:Tumour-associated macrophages have been shown to promote proliferation, angiogenesis and metastasis in several carcinomas. The effect on colon cancer has not yet been clarified. Furthermore, Kupffer cells in the liver might initiate the formation of metastases by directly binding tumour cells. METHODS:An ortho...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Kruse J,von Bernstorff W,Evert K,Albers N,Hadlich S,Hagemann S,Günther C,van Rooijen N,Heidecke CD,Partecke LI

    更新日期:2013-10-01 00:00:00

  • Clinical and manometric effects of combined external beam irradiation and brachytherapy for anal cancer.

    abstract::This study evaluates anorectal function after combined tele- and brachytherapy for anal cancer using manometric measurements and a standardized questionnaire. Eight patients received 44 +/- 3 Gy external beam radiation followed by 20 +/- 4 Gy interstitial brachytherapy with iridium-192. Patients were examined 43 month...

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章


    authors: Broens P,Van Limbergen E,Penninckx F,Kerremans R

    更新日期:1998-01-01 00:00:00

  • hTERT expression in colorectal adenocarcinoma: correlations with p21, p53 expressions and clinicopathological features.

    abstract:BACKGROUND:The clinicopathological roles and relationships of hTERT, p21 and p53 proteins have not been studied in depth in colorectal cancer. The aim of the present study is to investigate the clinicopathological roles of expression of hTERT protein expression and its relationship with the expression of p21 and p53 pr...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Lam AK,Ong K,Ho YH

    更新日期:2008-06-01 00:00:00

  • Long-term manometric study of anal sphincter function after hemorrhoidectomy.

    abstract:BACKGROUND AND AIM:Data on maximum resting pressure (MRP) and maximum squeeze pressure (MSP) changes after hemorrhoidectomy are not univocal and follow-up of patients undergoing surgery is mostly short-lived. The aim of this study was to prospectively examine during 1-year follow-up the long-term manometric results of ...

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章


    authors: Patti R,Almasio PL,Arcara M,Sparacello M,Termine S,Bonventre S,Di Vita G

    更新日期:2007-03-01 00:00:00

  • Pattern of recurrence in rectal carcinoma: implications for the design of (future) studies on adjuvant therapy.

    abstract::255 patients who underwent potentially curative surgical treatment for rectal carcinoma at the Cantonal Hospital Aarau from 1981 to 1989 have been followed up and the results analysed for overall survival and the timing and occurrence of local and distant recurrence in relation to the initial tumor stage. The patients...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Barras JP,Bachmann R,Aeberhard P

    更新日期:1993-09-01 00:00:00

  • Intestinal adenosquamous carcinoma with a synchronous skin metastasis: a immunohistochemical and molecular analysis.

    abstract:INTRODUCTION:Intestinal adenosquamous carcinoma (ASC) is a rare colorectal neoplasm frequently occurring at onset as a locally advanced disease with distant metastases. The liver is the most common site of metastasis, followed by the peritoneum and the lung. Cutaneous metastases from usual colorectal adenocarcinoma occ...

    journal_title:International journal of colorectal disease



    authors: Parente P,Covelli C,Parrella P,Latiano TP,Fiordelisi F,Pellico MT,Maiello E,Graziano P

    更新日期:2020-02-01 00:00:00

  • The impact of an ostomy on older colorectal cancer patients: a cross-sectional survey.

    abstract:BACKGROUND:Ostomies are being placed in 35 % of patients after colorectal cancer surgery. As decision-making regarding colorectal surgery is challenging in the older patients, it is important to have insight in the potential impact due to ostomies. METHODS:An internet-based survey was sent to all members with register...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Verweij NM,Hamaker ME,Zimmerman DD,van Loon YT,van den Bos F,Pronk A,Borel Rinkes IH,Schiphorst AH

    更新日期:2017-01-01 00:00:00

  • Adenocarcinoma of the ileoanal pouch for ulcerative colitis--a complication of severe chronic atrophic pouchitis?

    abstract:BACKGROUND:The appearance of a carcinoma in the ileal pouch after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative proctocolitis is rare. Most of these adenocarcinomas previously described in literature develop from residual viable rectal mucosa. We report a case of an adenocarcinoma ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Knupper N,Straub E,Terpe HJ,Vestweber KH

    更新日期:2006-07-01 00:00:00

  • Post-polypectomy surveillance colonoscopy: are we following the guidelines?

    abstract:PURPOSE:Polyps are a common finding on colonoscopy procedures. After completing polypectomy, patients are to be followed up with endoscopy. The purpose of the study was to assess the adherence of gastroenterologists to international post-polypectomy guidelines. METHODS:Israeli gastroenterologists answered a questionna...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Abu Freha N,Abu Tailakh M,Elkrinawi J,Abu Kaf H,Philip A,Schwartz D,Yahia A,Etzion O

    更新日期:2020-07-01 00:00:00

  • Hartmann's procedure in rectal cancer: a population-based study of postoperative complications.

    abstract:PURPOSE:Hartmann's procedure for rectal cancer patients is increasingly performed but few studies have reported the postoperative outcome. The purpose was to report postoperative complications and analyse risk factors in rectal cancer patients operated with Hartmann's procedure. To describe the selection and postoperat...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Sverrisson I,Nikberg M,Chabok A,Smedh K

    更新日期:2015-02-01 00:00:00

  • Strictureplasty for active Crohn's disease.

    abstract:BACKGROUND AND AIMS:Several studies over the last 20 years have confirmed the safety and efficacy of strictureplasty in the treatment of obstructive Crohn's disease. However, almost all of these studies use strictureplasty to treat fibrotic strictures: limited resection being preferred to treat active disease stricture...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Roy P,Kumar D

    更新日期:2006-07-01 00:00:00

  • Laterally spreading tumors of the colorectum: clinicopathologic features and malignant potential by macroscopic morphology.

    abstract:BACKGROUND/AIMS:Laterally spreading tumors (LSTs) are being increasingly reported nowadays. The aims of this study were to analyze the clinicopathologic characteristics and to identify the risk factors of malignancy in patients with LSTs by morphological subclassification. PATIENTS AND METHODS:The authors retrospectiv...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Kim KO,Jang BI,Jang WJ,Lee SH

    更新日期:2013-12-01 00:00:00

  • New approach to large haemorrhoidal prolapse: double stapled haemorrhoidopexy.

    abstract:PURPOSE:To verify if in large haemorrhoidal prolapse (independently from the degree) in patients with no symptoms of obstructed defaecation syndrome, the use of a stapled hemorrhoidopexy variant, comprising a double stapler haemorrhoidopexy (DSH), makes it possible to reduce the percentage of failures or relapses and t...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Naldini G,Martellucci J,Talento P,Caviglia A,Moraldi L,Rossi M

    更新日期:2009-12-01 00:00:00

  • Extent of surgery and recurrence rate of hidradenitis suppurativa.

    abstract::Hidradenitis suppurativa (HS) is a chronic fistula- and abscess-forming disease of the cutis and subcutis of unknown etiology. Disease recurrence is frequent and may cause severe complications. We analyzed patients with HS who underwent surgery between 1976 and 1997. The operative procedures were divided into drainage...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Ritz JP,Runkel N,Haier J,Buhr HJ

    更新日期:1998-01-01 00:00:00

  • Interposition of vital bulbocavernosus graft in the treatment of both simple and recurrent rectovaginal fistulas.

    abstract:OBJECTIVE:The objective of the study is to assess the efficacy of vital bulbocavernosus graft transposition in the treatment of rectovaginal fistula. MATERIALS AND METHODS:From March 2003 to October 2007, nine consecutive patients diagnosed with rectovaginal fistula were refereed to our institute. All patients were tr...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Cui L,Chen D,Chen W,Jiang H

    更新日期:2009-11-01 00:00:00

  • Technique for laparoscopic autonomic nerve preserving total mesorectal excision.

    abstract::With the introduction of total mesorectal excision (TME) for treatment of rectal cancer, the prognosis of patients with rectal cancer is improved. With this better prognosis, there is a growing awareness about the quality of life of patients after rectal carcinoma. Laparoscopic total mesorectal excision (LTME) for rec...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Breukink SO,Pierie JP,Hoff C,Wiggers T,Meijerink WJ

    更新日期:2006-05-01 00:00:00

  • Soluble intercellular adhesion molecule-1 is a prognostic marker in colorectal carcinoma.

    abstract:PURPOSE:Serological tumor markers are routinely used to monitor tumor onset and progression. In colorectal carcinoma (CRC), the carcinoembryonic antigen (CEA) is roughly elevated in 50% of patients at initial diagnosis. Soluble ICAM-1 (sICAM-1) is elevated in different cancers. The aim of this study was to evaluate the...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Schellerer VS,Langheinrich MC,Zver V,Grützmann R,Stürzl M,Gefeller O,Naschberger E,Merkel S

    更新日期:2019-02-01 00:00:00