Rescue therapy with tacrolimus in a patient with toxic megacolon.

Abstract:

BACKGROUND:Toxic megacolon is a life-threatening complication most commonly observed in patients with ulcerative colitis or Crohn's disease that is characterized by total or segmental nonobstructive colonic dilatation of at least 6 cm on plain abdominal films associated with systemic toxicity. CASE REPORT:We report an unusual case of fulminant steroid-refractory ulcerative colitis complicated by toxic megacolon treated successfully with the immunosuppressant tacrolimus. CONCLUSION:Tacrolimus administration induced clinical remission and bridged the time interval, until the standard immunosuppressant azathioprine could maintain clinical remission, thereby avoiding eminent emergency colectomy.

journal_name

Int J Colorectal Dis

authors

Pascu M,Müller AR,Wiedenmann B,Dignass AU

doi

10.1007/s00384-002-0458-8

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

271-5

issue

3

eissn

0179-1958

issn

1432-1262

journal_volume

18

pub_type

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