Ghrelin as a potential anti-obesity target.

abstract：:Inhibition of the renin-angiotensin system (RAS) has been shown to have beneficial effects in cardiovascular disease prognosis and therapy.Discovery of (pro)renin receptor [(P)RR] revealed that (P)RR upon binding to both renin or prorenin in their proenzyme inactive form made them enzymatically active, thus aiding the...

journal_title：Current pharmaceutical design

authors： Ando T,Ichihara A

更新日期：2014-01-01 00:00:00

abstract：:Oxidative and nitrosative stress triggers DNA strand breakage, which then activates the nuclear enzyme poly(ADP-ribose) polymerase (PARP). One of the key triggers of DNA single strand breakage in pathophysiological conditions is peroxynitrite, a reactive species produced from the reaction of nitric oxide and superoxid...

journal_title：Current pharmaceutical design

authors： Gero D,Szabó C

更新日期：2006-01-01 00:00:00

abstract：:Angiogenesis is the process by which new blood vessels are formed from preexisting microvasculature. To ensure an adequate blood supply, tumor cells release angiogenic factors that are capable of promoting nearby blood vessels to extend vascular branches to the tumor. In addition, larger tumors have been shown to rele...

journal_title：Current pharmaceutical design

authors： Gourley M,Williamson JS

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Despite the limited evidence about the effect of micronutrient supplementation on the semen quality, many micronutrient supplements have been used to improve male fertility. Approximately, 40%-50% of male infertility cases in general and up to 80% in men with idiopathic infertility cases are caused by oxidat...

journal_title：Current pharmaceutical design

authors： Dimitriadis F,Tsounapi P,Zachariou A,Kaltsas A,Sokolakis I,Hatzichristodoulou G,Symeonidis EN,Kotsiris D,Gabales MR,Vlachopoulou E,Takenaka A,Sofikitis N

更新日期：2020-04-15 00:00:00

abstract：:Although somewhat controversial, there is good evidence that long-distance travel in general is a risk factor for venous thromboembolism, even in the absence of other risk factors. This is probably due to effects consequent to prolonged sitting but air travel in particular may be associated with risk factors other tha...

journal_title：Current pharmaceutical design

authors： Bradford A

更新日期：2007-01-01 00:00:00

abstract：:The activities of individual cells must be tightly coordinated in order to build and maintain complex 3- dimensional body structures during embryogenesis and regeneration. Thus, one way to view cancer is within systems biology as a network disorder affecting the ability of cells to properly interact with a morphodynam...

journal_title：Current pharmaceutical design

authors： Tuszynski J,Tilli TM,Levin M

更新日期：2017-01-01 00:00:00

abstract：:The HIV/AIDS pandemic continues its spread at a rate of over 15,000 new infections every day. Sexual transmission of HIV-1 is the dominant mode of this pandemic spread. For the first time since the disease emerged in the early 1980s, about half the 42 million people now living with HIV/AIDS worldwide are women. Worldw...

journal_title：Current pharmaceutical design

authors： D'Cruz OJ,Uckun FM

更新日期：2004-01-01 00:00:00

abstract：:Type 2 diabetes is associated with substantially increased cardiovascular mortality. The need to reduce the progression of atherosclerosis alongside lowering blood glucose levels is now well established. Ideally, pharmaceutical treatment should address both of these needs. This review summarises current evidence of th...

journal_title：Current pharmaceutical design

authors： Papanas N,Maltezos E

更新日期：2009-01-01 00:00:00

abstract：:In the last two decades quantitative electroencephalogram (EEG) analysis has been widely used to investigate the neurophysiological characteristics of insomnia. These studies provided evidence in support of the hypothesis that primary insomnia is associated with hyperarousal of central nervous system and altered sleep...

journal_title：Current pharmaceutical design

authors： Marzano C,Ferrara M,Sforza E,De Gennaro L

更新日期：2008-01-01 00:00:00

abstract：:The complex system of molecular communications underlying cell biochemistry and function involves numerous components including kinases, phosphatases and transcription factors, which are known to be sensitive to cellular and tissue redox changes. Reactive oxygen species (ROS), whose constitutive generation in cells an...

journal_title：Current pharmaceutical design

authors： Leonarduzzi G,Sottero B,Testa G,Biasi F,Poli G

更新日期：2011-12-01 00:00:00

abstract：:Transient left ventricular dysfunction in patients under emotional stress, also known as Takotsubo cardiomyopathy, has been recognized as a distinct clinical entity. Recent studies have supported the concept notion that the cardiovascular system is regulated by cortical modulation. A network consisting of the insular ...

journal_title：Current pharmaceutical design

authors： Nagai M,Dote K,Kato M,Sasaki S,Oda N,Kagawa E,Nakano Y,Yamane A,Higashihara T,Miyauchi S,Tsuchiya A,Harada W,Kario K

更新日期：2017-01-01 00:00:00

abstract：:Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic relapsing conditions resulting from immune system activity in a genetically predisposed individual. IBD is based on progressive damage to the inflamed gut tissue. As its pathogenesis remains unknown, recent accumu...

journal_title：Current pharmaceutical design

authors： Alimohammadi N,Koosha F,Rafeian-Kopaei M

更新日期：2020-01-01 00:00:00

abstract：:The solid lipid nanoparticles (SLNs) usually consists of active drug molecules along with solid lipids, surfactants, and/or co-surfactants. They possess some potential features such as nano-size, surface with a free functional group to attach ligands, and as well they prove safe homing for both lipophilic as well as h...

journal_title：Current pharmaceutical design

authors： Rajpoot K

更新日期：2019-01-01 00:00:00

abstract：:Tissue-engineered oral mucosal equivalents have been developed for in vitro studies for a few years now. However, the usefulness of currently available models is still limited by many factors, mainly the lack of a physiological extracellular matrix (ECM) and the use of cell populations that do not reflect the properly...

journal_title：Current pharmaceutical design

authors： Bucchieri F,Fucarino A,Marino Gammazza A,Pitruzzella A,Marciano V,Paderni C,De Caro V,Siragusa MG,Lo Muzio L,Holgate ST,Davies DE,Farina F,Zummo G,Kudo Y,Giannola IL,Campisi G

更新日期：2012-01-01 00:00:00

abstract：:Gene therapy, currently, represents one of the new therapies that have emerged for the treatment of different diseases. Between the different approaches that can be chosen concerning this therapy, gene delivery with non-viral systems has focused the attention during the past decades, because of the reduced toxicity co...

journal_title：Current pharmaceutical design

authors： Urbiola K,Blanco-Fernandez L,de Ilarduya CT

更新日期：2015-01-01 00:00:00

abstract：:Oxidative processes exert a fundamental regulatory function during pregnancy. It depends on the influence of oxygen, nitric oxide, reactive oxygen species and reactive nitrogen species metabolic pathways upon the vascular changes in the maternal organism, as well as on the regulation of uterine and cervical tone throu...

journal_title：Current pharmaceutical design

authors： Biondi C,Pavan B,Lunghi L,Fiorini S,Vesce F

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a novel category of oral antidiabetic drugs that inhibit renal glucose reabsorption and increase renal glucose excretion, thus lowering plasma glucose levels. This unique mechanism of SGLT2i action is insulin independent, thus improving glycemic control ...

journal_title：Current pharmaceutical design

authors： Katsiki N,Mikhailidis DP,Theodorakis MJ

更新日期：2017-01-01 00:00:00

abstract：:The involvement of the central nervous system (CNS) is one of the major causes of morbidity and mortality in systemic lupus erythematosus (SLE) patients and the less understood aspect of the disease. Its recognition and treatment continue to represent a major diagnostic and therapeutic challenge. Due to the lack of co...

journal_title：Current pharmaceutical design

authors： Sanna G,Bertolaccini ML,Khamashta MA

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Enhancing a compound's biological activity is the central task for lead optimization in small molecules drug discovery. However, it is laborious to perform many iterative rounds of compound synthesis and bioactivity tests. To address the issue, it is highly demanding to develop high quality in silico bioacti...

journal_title：Current pharmaceutical design

authors： Ding X,Cui C,Wang D,Zhao J,Zheng M,Luo X,Jiang H,Chen K

更新日期：2020-01-01 00:00:00

abstract：:Naturally occurring abietane diterpenoids have been studied over the years and have shown to display a wide range of biological activities. This review covers three main aspects of the abietane-type diterpenoids with hydroxy-p-quinone C ring, designated as royleanones. An overview of 1) the naturally occurrence, 2) ch...

journal_title：Current pharmaceutical design

authors： Ladeiras D,Monteiro CM,Pereira F,Reis CP,Afonso CA,Rijo P

更新日期：2016-01-01 00:00:00

abstract：:The human herpesviruses herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) can cause severe recurrent disease in humans and establish lifelong infection in their hosts. Several antiviral therapies are available to control disease and spread, but these are not completely effective and do not affect latent virus. The ...

journal_title：Current pharmaceutical design

authors： Ramachandran S,Kinchington PR

更新日期：2007-01-01 00:00:00

abstract：:In the brain, acetylcholine (ACh) is regarded as one of the major neurotransmitters. During the advancement of Alzheimer's disease (AD) cholinergic deficits occur and this can lead to extensive cognitive dysfunction and decline. Acetylcholinesterase (AChE) remains a highly feasible target for the symptomatic improveme...

journal_title：Current pharmaceutical design

authors： Kabir MT,Uddin MS,Begum MM,Thangapandiyan S,Rahman MS,Aleya L,Mathew B,Ahmed M,Barreto GE,Ashraf GM

更新日期：2019-01-01 00:00:00

abstract：:Protection of the brain is strengthened by active transport and ABC transporters. P-glycoprotein (P-gp) at the blood-brain barrier (BBB) functions as an active efflux pump by extruding a substrate from the brain, which is important for maintaining loco-regional homeostasis in the brain and protection against toxic com...

journal_title：Current pharmaceutical design

authors： Bartels AL

更新日期：2011-01-01 00:00:00

abstract：:Many therapeutically active medications have significant side effects, some of which can compromise the intended therapeutic goal. The development of plasma lipid abnormalities or a dyslipidemia as the result of a medication intended for an unrelated effect has been reported. Human immunodeficiency virus (HIV) infecti...

journal_title：Current pharmaceutical design

authors： Whayne TF,Mukherjee D

更新日期：2014-01-01 00:00:00

abstract：:New biopharmaceutical molecules, potentially able to provide more personalized and effective treatments, are being identified through the advent of advanced synthetic biology strategies, sophisticated chemical synthesis approaches, and new analytical methods to assess biological potency. However, translation of many o...

journal_title：Current pharmaceutical design

authors： Munsell EV,Ross NL,Sullivan MO

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Progression of aortic valve calcifications (AVC) leads to aortic valve stenosis (AS). Importantly, the AVC degree has a great impact on AS progression, treatment selection and outcomes. Methods of AVC assessment do not provide accurate quantitative evaluation and analysis of calcium distribution and depositi...

journal_title：Current pharmaceutical design

authors： Wiktorowicz A,Wit A,Dziewierz A,Rzeszutko L,Dudek D,Kleczynski P

更新日期：2019-01-01 00:00:00

abstract：:The prevalence of obesity is increasing globally. Rational perioperative anesthetic drug selection and administration require knowledge of how obesity interacts with those drugs. In this review, we summarize different aspects of the anesthetic agents, including pharmacokinetics (PK), pharmacodynamics (PD) and clinical...

journal_title：Current pharmaceutical design

authors： Dos Reis Falcão LF,Mc Loughlin S,Alvarez A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Atherosclerosis is a chronic inflammatory disease and a leading cause of coronary artery disease, peripheral vascular disease and stroke. Lipid-laden macrophages are derived from circulating monocytes and form fatty streaks as the first step of atherogenesis. METHODS:An electronic search in major databases ...

journal_title：Current pharmaceutical design

authors： Taghizadeh E,Taheri F,Renani PG,Reiner Ž,Navashenaq JG,Sahebkar A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Bacterial cellulose (BC) has recently attained greater interest in various research fields, including drug delivery for biomedical applications. BC has been studied in the field of drug delivery, such as tablet coating, controlled release systems and prodrug design. OBJECTIVE:In the current work, we tested ...

journal_title：Current pharmaceutical design

authors： Ullah H,Badshah M,Correia A,Wahid F,Santos HA,Khan T

更新日期：2019-01-01 00:00:00

abstract：:DNA methylation, a major regulator of epigenetic modifications has been shown to alter the expression of genes that are involved in aspects of glucose metabolism such as glucose intolerance, insulin resistance, β-cell dysfunction and other conditions, and it ultimately leads to the pathogenesis of type 2 diabetes mell...

journal_title：Current pharmaceutical design

authors： Alam F,Islam MA,Gan SH,Mohamed M,Sasongko TH

更新日期：2016-01-01 00:00:00