Calcium Pattern Assessment in Patients with Severe Aortic Stenosis Via the Chou's 5-Steps Rule.

abstract：:The introduction of highly active anti-retroviral therapy (HAART) for Human Immunodeficiency Virus (HIV) infection has significantly improved the life expectancy of HIV positive patients. Hepatitis C virus (HCV) co-infection is common in HIV infected patients and is now a significant cause of morbidity and mortality. ...

journal_title：Current pharmaceutical design

authors： Fabris P,Barnes E,Tositti G,Giordani MT,Grasso A,De Lalla F

更新日期：2004-01-01 00:00:00

abstract：:Adenosine triphosphate (ATP) synthase produces ATP in cells and is found on the inner membrane of mitochondria or the cell plasma membrane (ectopic ATP synthase). Here, we summarize the functions of ectopic ATP synthase in vascular endothelial cells (ECs). Ectopic ATP synthase is involved in adenosine metabolism on th...

journal_title：Current pharmaceutical design

authors： Fu Y,Zhu Y

更新日期：2010-01-01 00:00:00

abstract：:The activation of Corticotrophin Releasing-Factor (CRF) receptors in the brain is well established to coordinate the endocrine, behavioral, autonomic and visceral responses to stress. In addition, CRF receptors are also expressed within the gut where they exert biological actions and play a role in modulating stress-r...

journal_title：Current pharmaceutical design

authors： Czimmer J,Tache Y

更新日期：2017-01-01 00:00:00

abstract：:Acute kidney injury (AKI) is relatively common in patients undergoing transcatheter aortic valve implantation (TAVI) and has been associated with increased mortality and worse outcomes. The administration of iodinated contrast media in an elderly population with increased rates of chronic kidney injury and heart failu...

journal_title：Current pharmaceutical design

authors： Kampaktsis PN,Feldman DN,Charitakis K

更新日期：2016-01-01 00:00:00

abstract：:Chronic pain is a widespread healthcare problem affecting not only the patient but in many ways all the society. Chronic pain is a disease itself that endures for a long period of time and it is resistant to the majority of medical treatments that provide modest improvements in pain and minimum improvements in physica...

journal_title：Current pharmaceutical design

authors： Del Bufalo A,Cesario A,Salinaro G,Fini M,Russo P

更新日期：2014-01-01 00:00:00

abstract：:Aspirin is the cornerstone of treatment in patients with coronary artery disease. However, several studies investigating the in vitro response of platelets to the administration of aspirin showed this response to be variable, with some patients exhibiting non-responsiveness or resistance. Aspirin resistance may be cat...

journal_title：Current pharmaceutical design

authors： Papathanasiou A,Goudevenos J,Tselepis AD

更新日期：2009-01-01 00:00:00

abstract：:siRNA-induced RNA Interference (RNAi) responses have great potential to treat human disease; however, siRNAs are highly charged macromolecules with no ability to enter cells and require a delivery agent. Peptide Transduction Domains (PTDs), also called Cell Penetrating Peptides (CPPs), are delivery peptides with the p...

journal_title：Current pharmaceutical design

authors： Presente A,Dowdy SF

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Although medications should only be prescribed in pregnancy if benefits to the mother outweigh the risk to the fetus, drug use in pregnancy especially prescribed and over-the-counter analgesics, is very common. OBJECTIVE:The objective of this review is to present an update on known changes in analgesic disp...

journal_title：Current pharmaceutical design

authors： Price HR,Collier AC

更新日期：2017-01-01 00:00:00

abstract：:Δ(9)-tetrahydrocannabinol (Δ(9)-THC) is the main compound of the Cannabis Sativa responsible for most of the effects of the plant. Another major constituent is cannabidiol (CBD), formerly regarded to be devoid of pharmacological activity. However, laboratory rodents and human studies have shown that this cannabinoid i...

journal_title：Current pharmaceutical design

authors： Zuardi AW,Crippa JA,Hallak JE,Bhattacharyya S,Atakan Z,Martin-Santos R,McGuire PK,Guimarães FS

更新日期：2012-01-01 00:00:00

abstract：:The concept of probiotics has evolved immensely since it was first proposed a century ago. There are numerous potential health benefits attributed to certain probiotic bacteria, from preventing gastrointestinal (GI) infections to stimulating the immune system. Recent evidence is now quite compelling for a role of prob...

journal_title：Current pharmaceutical design

authors： O'Sullivan DJ

更新日期：2008-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers globally and is associated with a high mortality rate. The transforming growth factor beta (TGF-β) signaling pathway plays an important role in normal intestinal tissue function, but has also been implicated in the development of CRC. MicroRNAs (miRNAs) have al...

journal_title：Current pharmaceutical design

authors： Moradi-Marjaneh R,Khazaei M,Ferns GA,Aghaee-Bakhtiari SH

更新日期：2018-01-01 00:00:00

abstract：:No-reflow, i.e., the lack of distal myocardial perfusion to fully recover following recanalization of an acutely occluded coronary artery, is not only a mere consequence of ischemic injury, as substantial microvascular alterations may also develop subsequently, after initial restoration of perfusion. Since part of per...

journal_title：Current pharmaceutical design

authors： Tritto I,Zuchi C,Vitale S,Ambrosio G

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Utilization of macroalgae has gained much attention in the field of pharmaceuticals, nutraceuticals, food and bioenergy. Macroalgae has been widely consumed in Asian countries as food from ancient days and proved that it has potential bioactive compounds which are responsible for its nutritional properties. ...

journal_title：Current pharmaceutical design

authors： Venkatesan J,Anil S,Rao S,Bhatnagar I,Kim SK

更新日期：2019-01-01 00:00:00

abstract：:Uveitis is a sight threatening intraocular inflammation accounting for approximately 10% of blindness worldwide. On the basis of aetiology, disease can be classified as infectious or non-infectious; and by anatomical localization of inflammation as anterior, posterior and panuveitis. Non-infectious uveitis is believed...

journal_title：Current pharmaceutical design

authors： Klaska IP,Forrester JV

更新日期：2015-01-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common sustained rhythm disturbance, increasing prevalence with age, in particular in patients with cardiovascular disease. On the other hand, a subset of patients with AF being <60 years old and no evidence of underlying cardiovascular disease, and laboratory tests including thyro...

journal_title：Current pharmaceutical design

authors： Tello-Montoliu A,Hernández-Romero D,Sanchez-Martínez M,Valdes M,Marín F

更新日期：2015-01-01 00:00:00

abstract：:The last decades have witnessed an explosion in studies of the role of amyloid-β (Aβ) in the progress of the neurodegenerative disorder Alzheimer's disease (AD) and it is now widely accepted that Aβ is related to the pathogenesis of AD. For example, studies have shown that Aβ is neurotoxic and that the neurotoxicity o...

journal_title：Current pharmaceutical design

authors： Portelius E,Mattsson N,Andreasson U,Blennow K,Zetterberg H

更新日期：2011-01-01 00:00:00

abstract：:The OB-receptor or leptin receptor (LR) is crucial for energy homeostasis and regulation of food uptake. Leptin is a 16 kDa hormone that is mainly secreted by fat cells into the bloodstream. Under normal circumstances, circulating leptin levels are proportionate to the fat body mass. Sensing of elevated leptin levels ...

journal_title：Current pharmaceutical design

authors： Tutone M,Lauria A,Almerico AM

更新日期：2014-01-01 00:00:00

abstract：:Diet has a high relevance in health. Hypertension is a major risk factor for cardiovascular diseases and has an important impact on public health, and consequently on countries economy. Scientific research gathered strong evidence about the role of several dietary factors either in etiology or in treatment/prevention ...

journal_title：Current pharmaceutical design

authors： Marques C,Amorim MM,Pereira JO,Pintado ME,Moura D,Calhau C,Pinheiro H

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Sulfur mustard (SM)-induced airway injuries and chronic obstructive pulmonary disease (COPD) are characterized by chronic inflammation of the respiratory tract and share some similarities regarding the cellular and molecular mechanisms orchestrating airway destruction. Since available data regarding the immu...

journal_title：Current pharmaceutical design

authors： Panahi Y,Jadidi-Niaragh F,Jamalkandi SA,Ghanei M,Pedone C,Nikravanfard N,Nikravesh F,Sahebkar A

更新日期：2016-01-01 00:00:00

abstract：:Drug designing targeting protein-protein interactions is challenging. Because structural elucidation and computational analysis have revealed the importance of hot spot residues in stabilizing these interactions, there have been on-going efforts to develop drugs which bind the hot spots and out-compete the native prot...

journal_title：Current pharmaceutical design

authors： Ma B,Nussinov R

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Plants have been used to treat health disorders and prevent diseases since antiquity in all civilizations including the Indian and Chinse civilizations. Giloy (Tinospora cordifolia L.) is one of the most important medicinal plants in Indian folk medicine and is commonly known as the "Heart-leaved Moonseed" o...

journal_title：Current pharmaceutical design

authors： Verma DK,Goyal K,Kumar P,El-Shazly M

更新日期：2020-06-25 00:00:00

abstract：:In the last two decades the development of efficient plant-based expression strategies and new concepts for the purification of recombinant proteins prompted the application of plant-derived vaccines for veterinary purposes. The expression of recombinant proteins in plants possesses advantages over conventional eukary...

journal_title：Current pharmaceutical design

authors： Phan HT,Floss DM,Conrad U

更新日期：2013-01-01 00:00:00

abstract：:While pharmacological blockade of dopamine D2 receptor can effectively suppress the psychotic or positive symptoms of schizophrenia, there is no satisfactory medication for the negative and cognitive symptoms of schizophrenia in spite of the proliferation of second generation antipsychotic drugs. Excitements over a ne...

journal_title：Current pharmaceutical design

authors： Singer P,Dubroqua S,Yee BK

更新日期：2015-01-01 00:00:00

abstract：:The concept that the gut microbiota plays a major role in the development of pouchitis in ulcerative colitis patients after restorative proctocolectomy with ileal pouch-anal anastomosis, is widely accepted and supported by a widespread use of some antibiotics (metronidazole and/or ciprofloxacin, rifaximin) to treat th...

journal_title：Current pharmaceutical design

authors： Guslandi M

更新日期：2014-01-01 00:00:00

abstract：:The gut microbiota plays significant roles in the human body during all spheres' of life and influences innate immunity, promotes granulocyte signaling and provides resistance during pathogenic colonization of the gut; crucial for a healthy life. Antibiotics directly affect the gut microbiota that consequently alters ...

journal_title：Current pharmaceutical design

authors： Paul D,Manna S,Mandal SM

更新日期：2018-01-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a severe vascular complication of connective tissue diseases. In the context of systemic sclerosis (SSc), PAH is a devastating disease with a dramatic impact on prognosis and survival. Despite advances in early diagnosis and the development of new targeted treatments, SSc-relat...

journal_title：Current pharmaceutical design

authors： Dimitroulas T,Giannakoulas G,Karvounis H,Settas L,Kitas GD

更新日期：2012-01-01 00:00:00

abstract：:The activities of individual cells must be tightly coordinated in order to build and maintain complex 3- dimensional body structures during embryogenesis and regeneration. Thus, one way to view cancer is within systems biology as a network disorder affecting the ability of cells to properly interact with a morphodynam...

journal_title：Current pharmaceutical design

authors： Tuszynski J,Tilli TM,Levin M

更新日期：2017-01-01 00:00:00

abstract：:There is a plausible role for cytokines, brain-derived neurotrophic factor (BDNF), and their interaction in major depressive disorder's (MDD) etiology. This review includes (i) briefly defining cytokines, (ii) a discussion of theories for why they may affect brain function, (iii) cross-sectional associations between c...

journal_title：Current pharmaceutical design

authors： Lotrich F

更新日期：2012-01-01 00:00:00

abstract：:The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within the first weeks or months of life is inevitable. Some diseases ca...

journal_title：Current pharmaceutical design

authors： McKay TR,Rahim AA,Buckley SM,Ward NJ,Chan JK,Howe SJ,Waddington SN

更新日期：2011-01-01 00:00:00

abstract：:There is growing evidence for the involvement of glutamatergic abnormalities in schizophrenia. Uncompetitive NMDA receptor (NMDAR) antagonists induce effects closely resembling both the positive and negative symptoms of schizophrenia; candidate risk genes for schizophrenia converge on the NMDAR expressing synapse; and...

journal_title：Current pharmaceutical design

authors： Stone JM

更新日期：2009-01-01 00:00:00