Antibiotics Associated Disorders and Post-biotics Induced Rescue in Gut Health.

abstract：BACKGROUND:In the field of forensic toxicology, the quality of analytical methods is of great importance to ensure the reliability of results and to avoid unjustified legal consequences. A key to high quality analytical methods is a thorough method development. METHODS:The presented article will provide an overview on...

journal_title：Current pharmaceutical design

authors： Peters FT,Wissenbach DK,Busardo FP,Marchei E,Pichini S

更新日期：2017-01-01 00:00:00

abstract：:The concept of probiotics has evolved immensely since it was first proposed a century ago. There are numerous potential health benefits attributed to certain probiotic bacteria, from preventing gastrointestinal (GI) infections to stimulating the immune system. Recent evidence is now quite compelling for a role of prob...

journal_title：Current pharmaceutical design

authors： O'Sullivan DJ

更新日期：2008-01-01 00:00:00

abstract：:Aquaporins (AQPs) are expressed in physiologically essential tissues and organs in which edema and fluid imbalances are of major concern. Potential roles in brain water homeostasis and edema, angiogenesis, cell migration, development, neuropathological diseases, and cancer suggest that this family of membrane proteins...

journal_title：Current pharmaceutical design

authors： Yool AJ

更新日期：2007-01-01 00:00:00

abstract：:Cancer therapies through ionizing radiation or chemotherapeutic treatment may result in DNA double strand breaks (DSBs) in cell. DNA-PK has emerged as an attractive target for drug discovery efforts toward DSBs repair and in V(D)J recombination. Hence, the search for potent and selective DNA-PK inhibitors has received...

journal_title：Current pharmaceutical design

authors： Cao R,Zeng H,Zhang H

更新日期：2009-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of chronic liver disease worldwide. This is primarily driven by the global epidemic of obesity and diabetes as well as the aging of the general population. Most of the epidemiology data of NAFLD for North America are published from stud...

journal_title：Current pharmaceutical design

authors： Arshad T,Golabi P,Henry L,Younossi ZM

更新日期：2020-01-01 00:00:00

abstract：:Atherosclerosis is an inflammatory vascular disease that is characterized by progressive accumulation of cholesterol in the arterial walls and it is a major cause of cardiovascular disease. Issues related to the side effects of synthetic drugs have in recent times, led to the misuse of drugs, a lack of patient consult...

journal_title：Current pharmaceutical design

authors： Gholipour S,Sewell RDE,Lorigooini Z,Rafieian-Kopaei M

更新日期：2018-01-01 00:00:00

abstract：:Doxorubicin has been a constituent of antitumor drug protocols for a broad spectrum of cancers for more than two decades. Side effects and resistance continue to be important limitations. Drug targets responsible for both side effects and anti-tumor activity are cell membrane receptors, cell membrane lipids, nucleic a...

journal_title：Current pharmaceutical design

authors： Taatjes DJ,Fenick DJ,Gaudiano G,Koch TH

更新日期：1998-06-01 00:00:00

abstract：:Periodontal disease is chronic inflammation of periodontal tissues resulting in formation of periodontal pockets, periodontal attachment loss and progressive destruction of the ligament and alveolar bone. This review gives an update on periodontal disease pathogenesis, which is important for the development of novel m...

journal_title：Current pharmaceutical design

authors： Zupancic S,Kocbek P,Baumgartner S,Kristl J

更新日期：2015-01-01 00:00:00

abstract：:There is an increased use of oral anticoagulants for the prevention of venous and arterial thrombosis. Vitamin-K antagonists have been used for decades as the main oral anticoagulants but they have the draback a complex therapeutic management, slow onset of action and by a different oral intake caused by dietary vitam...

journal_title：Current pharmaceutical design

authors： Lamperti M,Khozenko A,Kumar A

更新日期：2019-01-01 00:00:00

abstract：:Multidrug resistance (MDR) is a phenomenon through which tumor cells develop resistance against the cytotoxic effects of various structurally and mechanistically unrelated chemotherapeutic agents. The most consistent feature in MDR is overexpression and/or overactivity of ATP-dependent drug efflux transporters. Other ...

journal_title：Current pharmaceutical design

authors： Ghandadi M,Sahebkar A

更新日期：2016-01-01 00:00:00

abstract：:Gestational diabetes mellitus is a common metabolic complication of pregnancy. Universal guidelines on gestational diabetes have been impeded by the long-term controversies on its definition and screening strategies. The prevalence of gestational diabetes is rising all over the world, is significantly influenced by et...

journal_title：Current pharmaceutical design

authors： Kousta E,Kontogeorgi A,Robinson S,Johnston DG

更新日期：2020-01-01 00:00:00

abstract：:The final aim/target of Pharmaceutical Sciences is to design successful dosage forms for effective therapy, considering individual patient needs and compliance. Development of new drug entities, particularly using peptides and proteins, is growing in importance and attracting increased interest, as they are specifical...

journal_title：Current pharmaceutical design

authors： Degim IT,Celebi N

更新日期：2007-01-01 00:00:00

abstract：:A new controlled delivery system has been developed for ropinirole (RP) for the treatment of Parkinson´s Disease (PD) consisting in PLGA microparticles (MPs) which exhibited in vitro constant release of RP (78.23 µg/day/10 mg MPs) for 19 days. The neuroprotective effects of RP released from MPs were evaluated in SKN-A...

journal_title：Current pharmaceutical design

authors： Negro S,Boeva L,Slowing K,Fernandez-Carballido A,Garcia-García L,Barcia E

更新日期：2017-01-01 00:00:00

abstract：:Since antibiotics use is currently limited due to undesired side effects and the increasing antibiotic resistance of various bacteria strains, there is a pressing need to develop new strategies and methods preventing epidemic outbreaks. The virulent potency of bacteria relies on a number of different extracellularly s...

journal_title：Current pharmaceutical design

authors： Burchacka E,Sieńczyk M

更新日期：2018-01-01 00:00:00

abstract：:Manufacturing of pharmaceutical solids involves different unit operations and processing steps such as powder blending, fluidization, sieving, powder coating, pneumatic conveying and spray drying. During these operations, particles come in contact with other particles, different metallic, glass or polymer surfaces and...

journal_title：Current pharmaceutical design

authors： Desai PM,Tan BM,Liew CV,Chan LW,Heng PW

更新日期：2015-01-01 00:00:00

abstract：:The mechanisms and factors causing or influencing degenerative diseases require tailor-made solutions. Natural polysaccharides are among the most versatile building units of the novel drug delivery systems. Their properties can be easily tailored to specific needs because they depend not only on the first-order struct...

journal_title：Current pharmaceutical design

authors： Karewicz A,Bielska D,Nowakowska M

更新日期：2012-01-01 00:00:00

abstract：:We carried out a systematic review of HPV vaccine pre- and post-licensure trials to assess the evidence of their effectiveness and safety. We find that HPV vaccine clinical trials design, and data interpretation of both efficacy and safety outcomes, were largely inadequate. Additionally, we note evidence of selective ...

journal_title：Current pharmaceutical design

authors： Tomljenovic L,Spinosa JP,Shaw CA

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:According to the World Health Organization (WHO), diabetes mellitus is considered the 7th leading cause of death as of 2016, while almost half of all deaths related to high blood glucose occur before the age of 70. According to the 2019 American Diabetes Association's (ADA) guidelines, metformin is the first...

journal_title：Current pharmaceutical design

authors： Gillani SW,Moosvi AF

更新日期：2020-01-01 00:00:00

abstract：:Marine plants, animals and microorganisms display steady growth in the ocean and are abundant carbohydrate resources. Specifically, natural polysaccharides obtained from brown algae have been drawing increasing attention owing to their great potential in pharmaceutical applications. This review describes the structura...

journal_title：Current pharmaceutical design

authors： Li J,Cai C,Yang C,Li J,Sun T,Yu G

更新日期：2019-01-01 00:00:00

abstract：:Rotaviruses are an important cause of human morbidity and mortality, representing the primary pathogens responsible for acute dehydrating diarrhea in children under the age of 3. The infectious rotavirus particle is made up of three concentric layers of protein, and contains a genome consisting of eleven segments of d...

journal_title：Current pharmaceutical design

authors： Patton JT,Vasquez-Del Carpio R,Spencer E

更新日期：2004-01-01 00:00:00

abstract：:Stem cell therapy heralds a new chapter in cardiovascular regenerative medicine. Cardiovascular implants are often used in both surgery and interventional cardiology. Cardiovascular stents are utilized in percutaneous coronary interventions (PCI), and are classified as either bare metal stents (BMS) or drug-eluting st...

journal_title：Current pharmaceutical design

authors： Tan A,Sumpio BE,Lee S,Seifalian AM

更新日期：2010-01-01 00:00:00

abstract：:Guidelines for the treatment of hypertension allow a wide range of choices to the physicians; however some differences are present about the preferred drugs to start treatment. The most important aim remains an adequate decrease of blood pressure, something not perfectly obtained in the general population, but some cl...

journal_title：Current pharmaceutical design

authors： Pende A,Dallegri F

更新日期：2012-01-01 00:00:00

abstract：:Withdrawn by the publisher. ...

journal_title：Current pharmaceutical design

authors：

更新日期：2018-11-13 00:00:00

abstract：:Peroxynitrite, the product of the reaction between nitric oxide and superoxide, is spontaneouly formed within most mammalian cells under physiological conditions. Initial work addressing the pathophysiology of peroxynitrite afforded the generally accepted notion that this compound would be the long-term neurotoxic nit...

journal_title：Current pharmaceutical design

authors： Bolanos JP,García-Nogales P,Almeida A

更新日期：2004-01-01 00:00:00

abstract：:The activities of individual cells must be tightly coordinated in order to build and maintain complex 3- dimensional body structures during embryogenesis and regeneration. Thus, one way to view cancer is within systems biology as a network disorder affecting the ability of cells to properly interact with a morphodynam...

journal_title：Current pharmaceutical design

authors： Tuszynski J,Tilli TM,Levin M

更新日期：2017-01-01 00:00:00

abstract：:Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a non-flavonoid polyphenol that may be present in a limited number of foodstuffs such as grapes and red wine. Resveratrol has been reported to exert a plethora of health benefits through many different mechanisms of action. This versatility and presence in the human di...

journal_title：Current pharmaceutical design

authors： Tomé-Carneiro J,Larrosa M,González-Sarrías A,Tomás-Barberán FA,García-Conesa MT,Espín JC

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:A mobile health application is an exciting, fast-paced domain that is likely to improve prenatal care. METHODS:In this narrative review, we summarise the use of mobile health applications in this setting with a special emphasis on both the benefits of remote monitoring devices and the potential pitfalls of ...

journal_title：Current pharmaceutical design

authors： Gyselaers W,Lanssens D,Perry H,Khalil A

更新日期：2019-01-01 00:00:00

abstract：:The involvement of the central nervous system (CNS) is one of the major causes of morbidity and mortality in systemic lupus erythematosus (SLE) patients and the less understood aspect of the disease. Its recognition and treatment continue to represent a major diagnostic and therapeutic challenge. Due to the lack of co...

journal_title：Current pharmaceutical design

authors： Sanna G,Bertolaccini ML,Khamashta MA

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Bacterial cellulose (BC) has recently attained greater interest in various research fields, including drug delivery for biomedical applications. BC has been studied in the field of drug delivery, such as tablet coating, controlled release systems and prodrug design. OBJECTIVE:In the current work, we tested ...

journal_title：Current pharmaceutical design

authors： Ullah H,Badshah M,Correia A,Wahid F,Santos HA,Khan T

更新日期：2019-01-01 00:00:00

abstract：:The activation of Corticotrophin Releasing-Factor (CRF) receptors in the brain is well established to coordinate the endocrine, behavioral, autonomic and visceral responses to stress. In addition, CRF receptors are also expressed within the gut where they exert biological actions and play a role in modulating stress-r...

journal_title：Current pharmaceutical design

authors： Czimmer J,Tache Y

更新日期：2017-01-01 00:00:00